4.8 Review

Targeting β-glucans, vital components of the Pneumocystis cell wall

Related references

Note: Only part of the references are listed.
Article Immunology

EphA2 Is a Lung Epithelial Cell Receptor for Pneumocystis β-Glucans

Theodore J. Kottom et al.

Summary: This study reveals that the beta-glucans of Pneumocystis can bind to the EphA2 receptor on lung epithelial cells, leading to phosphorylation of the receptor and induction of inflammatory response. The cytokine interleukin 6 is significantly increased in response to Pneumocystis beta-glucans, and this response can be blocked by a specific antibody. The findings suggest the importance of EphA2 in the initial binding and proliferation of Pneumocystis in the host lung.

JOURNAL OF INFECTIOUS DISEASES (2022)

Review Immunology

Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity

Theodore J. Kottom et al.

Summary: Pneumocystis jirovecii is a common fungal pathogen in immunocompromised individuals, causing significant host immune response driven by cell wall components. These components interact with CLRs, leading to activation of proinflammatory signaling pathways. This minireview summarizes known CLR/Pneumocystis interactions.

FRONTIERS IN IMMUNOLOGY (2021)

Review Infectious Diseases

Diagnostic accuracy of serum (1-3)-β-D-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis

Olivier Del Corpo et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

Article Cell Biology

A critical role forCARD9in pneumocystis pneumonia host defence

Theodore J. Kottom et al.

CELLULAR MICROBIOLOGY (2020)

Article Immunology

Characterization of Pneumocystis murina Bgl2, an Endo-β-1,3-Glucanase and Glucanosyltransferase

Geetha Kutty et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

Article Microbiology

EphA2 is an epithelial cell pattern recognition receptor for fungal beta-glucans

Marc Swidergall et al.

NATURE MICROBIOLOGY (2018)

Article Microbiology

Pneumocystis and interactions with host immune receptors

Jennifer Claire Hoving

PLOS PATHOGENS (2018)

Article Microbiology

Binding of Pneumocystis carinii to the lung epithelial cell receptor HSPA5 (GRP78)

Theodore J. Kottom et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2018)

Article Microbiology

Lactate signalling regulates fungal β-glucan masking and immune evasion

Elizabeth R. Ballou et al.

NATURE MICROBIOLOGY (2017)

Article Infectious Diseases

Pneumocystis pneumonia suspected cases in 604 non-HIV and HIV patients

Anne-Lise Bienvenu et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2016)

Article Immunology

β-Glucans Are Masked but Contribute to Pulmonary Inflammation During Pneumocystis Pneumonia

Geetha Kutty et al.

JOURNAL OF INFECTIOUS DISEASES (2016)

Article Cell Biology

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J. W. Arts et al.

CELL REPORTS (2016)

Review Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

Sky W. Brubaker et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Article Immunology

Pneumocystis Encodes a Functional Endo-β-1,3-glucanase That is Expressed Exclusively in Cysts

Geetha Kutty et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

Review Biotechnology & Applied Microbiology

Pathobiology of Pneumocystis pneumonia: life cycle, cell wall and cell signal transduction

Joseph H. Skalski et al.

FEMS YEAST RESEARCH (2015)

Article Immunology

MyD88 Signaling Regulates Both Host Defense and Immunopathogenesis during Pneumocystis Infection

Sheila N. Bello-Irizarry et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Immunology

Clearance of Pneumocystis murina infection is not dependent on MyD88

Chiara Ripamonti et al.

MICROBES AND INFECTION (2014)

Article Multidisciplinary Sciences

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity

Shih-Chin Cheng et al.

SCIENCE (2014)

Article Immunology

Dectin Immunoadhesins and Pneumocystis Pneumonia

David M. Ricks et al.

INFECTION AND IMMUNITY (2013)

Article Biochemistry & Molecular Biology

The Pneumocystis Ace2 Transcription Factor Regulates Cell Wall-remodeling Genes and Organism Virulence

Theodore J. Kottom et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Glycosphingolipids Mediate Pneumocystis Cell Wall β-Glucan Activation of the IL-23/IL-17 Axis in Human Dendritic Cells

Eva M. Carmona et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

Review Immunology

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

David Sancho et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

Article Critical Care Medicine

An Official American Thoracic Society Statement: Treatment of Fungal Infections in Adult Pulmonary and Critical Care Patients

Andrew H. Limper et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Pneumocystis: from a doubtful unique entity to a group of highly diversified fungal species

Magali Chabe et al.

FEMS YEAST RESEARCH (2011)

Article Biochemistry & Molecular Biology

Characterization of PCEng2, a β-1,3-Endoglucanase Homolog in Pneumocystis carinii with Activity in Cell Wall Regulation

Leah R. Villegas et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

Article Microbiology

A drug-sensitive genetic network masks fungi from the immune system

Robert T. Wheeler et al.

PLOS PATHOGENS (2006)

Article Biochemistry & Molecular Biology

Pneumocystis cell wall β-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-κB-dependent mechanisms

SE Evans et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Pneumocystis carinii cell wall β-glucans initiate macrophage inflammatory responses through NF-κB activation

F Lebron et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Immunology

Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2

BN Gantner et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Article Multidisciplinary Sciences

Immune recognition -: A new receptor for β-glucans

GD Brown et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Vitronectin and fibronectin function as glucan binding proteins augmenting macrophage responses to Pneumocystis carinii

R Vassallo et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Cell wall assembly by Pneumocystis carinii -: Evidence for a unique Gsc-1 subunit mediating β-1,3-glucan deposition

TJ Kottom et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)