☆ 4.8 Review

Active ingredients of traditional Chinese medicine for enhancing the effect of tumor immunotherapy

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Antitumour immunity regulated by aberrant ERBB family signalling

Shogo Kumagai et al.

Summary: Aberrant signalling of ERBB family members plays a key role in tumorigenesis and antitumour immunity evasion. While molecular-targeted agents and immunotherapies show efficacy in various cancers, their effectiveness is limited in cancers with activating gene alterations of ERBB family members.

NATURE REVIEWS CANCER (2021)

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Article Integrative & Complementary Medicine

Anti-tumor and Phenotypic Regulation Effect of Matrine on Dendritic Cells through Regulating TLRs Pathway

Jing-kang Wang et al.

Summary: Matrine exerts anti-tumor effects by regulating TLRs signal transduction pathway, promoting the secretion of inflammatory cytokines, and enhancing immune function.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

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Review Oncology

The tumor microenvironment of lymphomas: Insights into the potential role and modes of actions of checkpoint inhibitors

Thomas Menter et al.

Summary: The interaction between lymphoma cells and the tumor microenvironment is crucial for the survival and proliferation of lymphoma cells. Understanding the immune-modulating role of the TME and exploring targeted therapies, such as immune checkpoints, are emerging areas of research in lymphoma treatment.

HEMATOLOGICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

Wenfang Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Medicine, Research & Experimental

Antitumor effects of immunity-enhancing traditional Chinese medicine

Yeshu Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Allergy

Mast Cell Biology at Molecular Level: a Comprehensive Review

Daniel Elieh Ali Komi et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

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Article Oncology

Effect of apigenin on whole transcriptome profile of TNFα-activated MDA-MB-468 triple negative breast cancer cells

David Bauer et al.

ONCOLOGY LETTERS (2020)

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Review Oncology

The roles of curcumin in regulating the tumor immunosuppressive microenvironment

Yizhi Wang et al.

ONCOLOGY LETTERS (2020)

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Article Cell Biology

Role of Mac-1 integrin in generation of extracellular vesicles with antibacterial capacity from neutrophilic granulocytes

Akos M. Lorincz et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Review Cell Biology

Interaction between microbiota and immunity in health and disease

Danping Zheng et al.

CELL RESEARCH (2020)

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Review Immunology

Neutrophil chemoattractant receptors in health and disease: double-edged swords

Mieke Metzemaekers et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Review Immunology

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

Ling Wu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Pharmacology & Pharmacy

Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin

Shuhui Zhang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Immunology

The role of B cell antigen presentation in the initiation of CD4+T cell response

Zhaolin Hua et al.

IMMUNOLOGICAL REVIEWS (2020)

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Review Immunology

Treg Heterogeneity, Function, and Homeostasis

Daniil Shevyrev et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Oncology

The role of cancer-derived microRNAs in cancer immune escape

Ming Yi et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Cell Biology

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

Alyssa Vito et al.

CELLS (2020)

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Article Immunology

In vivoDownregulation of MHC Class I Molecules by HCMV Occurs During All Phases of Viral Replication but Is Not Always Complete

Florin Gabor et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Immunology

Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation

Yuhui Yang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Pharmacology & Pharmacy

Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Yang Liu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Review Immunology

CD137/CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases

Hiu Yi Wong et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Chemistry, Multidisciplinary

T-Cell-Mimicking Nanoparticles for Cancer Immunotherapy

Mikyung Kang et al.

ADVANCED MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

Chunxiao Li et al.

MOLECULAR CANCER (2020)

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Article Immunology

In-vitro and in-vivo anti-breast cancer activity of synergistic effect of berberine and exercise through promoting the apoptosis and immunomodulatory effects

Wenyu Ma et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

The Important Role of Volatile Components From a Traditional Chinese Medicine Dayuan-Yin Against the COVID-19 Pandemic

Xiao-rui Zhang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Oncology

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Vivian Weiwen Xue et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation

Yoo-Jin Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer

Krystal Villalobos-Ayala et al.

CANCERS (2020)

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Review Immunology

The therapeutic potential of resveratrol in a mouse model of melanoma lung metastasis

Amirhossein Davoodvandi et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Xiaoliang Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Regulatory T cells in cancer immunosuppression - implications for anticancer therapy

Yosuke Togashi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Article Materials Science, Biomaterials

Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation

Wenfang Li et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Biotechnology & Applied Microbiology

Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition

Victoria A. Jennings et al.

MOLECULAR THERAPY (2019)

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Review Oncology

TRAIL and FasL Functions in Cancer and Autoimmune Diseases: Towards an Increasing Complexity

Aurelie Rossin et al.

CANCERS (2019)

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Article Immunology

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

Claudia Carenza et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine

Roberto S. Accolla et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade

Wen-Chien Huang et al.

CANCERS (2019)

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Review Oncology

Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer

Hao-fan Wang et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Cell Biology

Exosomes derived from pro-inflammatory bone marrow-derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization

Ruqin Xu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

Chen Lu et al.

MOLECULAR CANCER (2019)

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Article Nutrition & Dietetics

Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

Oluwaseun Adebayo Bamodu et al.

NUTRIENTS (2019)

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Review Immunology

The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma

Peng Liao et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

Christopher Groth et al.

BRITISH JOURNAL OF CANCER (2019)

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Review Oncology

Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism

Jingjing Zhu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

ETCM: an encyclopaedia of traditional Chinese medicine

Hai-Yu Xu et al.

NUCLEIC ACIDS RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

Xiaolei Li et al.

MOLECULAR CANCER (2019)

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Article Oncology

Whole Transcriptomic Analysis of Apigenin on TNFα Immuno-activated MDA-MB-231 Breast Cancer Cells

David Bauer et al.

CANCER GENOMICS & PROTEOMICS (2019)

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Editorial Material Biochemical Research Methods

Introduction to the Immune System

Scott McComb et al.

IMMUNOPROTEOMICS: METHODS AND PROTOCOLS, 2ND EDITION (2019)

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Article Pharmacology & Pharmacy

Cowpea Mosaic Virus Promotes Anti-Tumor Activity and Immune Memory in a Mouse Ovarian Tumor Model

Chao Wang et al.

ADVANCED THERAPEUTICS (2019)

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Article Oncology

Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis

Hui Hu et al.

ONCOLOGY REPORTS (2018)

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Article Oncology

Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells

Brian J. Morrison et al.

BMC CANCER (2018)

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Review Biochemistry & Molecular Biology

Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

Lucille C. Rankin et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth

Anchalee Rawangkan et al.

MOLECULES (2018)

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Article Oncology

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

Lu Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Effects of tumor metabolic microenvironment on regulatory T cells

Yi-an Wang et al.

MOLECULAR CANCER (2018)

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Article Integrative & Complementary Medicine

Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury

Luo Yun-Xia et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2018)

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Article Environmental Sciences

Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo

Shih-Feng Chan et al.

ENVIRONMENTAL TOXICOLOGY (2017)

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Review Biochemical Research Methods

Secreted Tumor Antigens - Immune Biomarkers for Diagnosis and Therapy

Els Meeusen et al.

PROTEOMICS (2017)

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Article Oncology

Resveratrol promotes MICA/B expression and natural killer cell lysis of breast cancer cells by suppressing c-Myc/miR-17 pathway

Jie Pan et al.

ONCOTARGET (2017)

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Article Multidisciplinary Sciences

Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer

Nadine Nelson et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells

David Bauer et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo

Lijing Zhou et al.

SCIENTIFIC REPORTS (2017)

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Article Medicine, Research & Experimental

Ginsenoside Rg3 attenuates cisplatin resistance in lung cancer by downregulating PD-L1 and resuming immune

Zhansheng Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Cell Biology

Resveratrol inhibits lung cancer growth by suppressing M2-like polarization of tumor associated macrophages

Liwei Sun et al.

CELLULAR IMMUNOLOGY (2017)

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Review Genetics & Heredity

Immunosuppressive cells in tumor immune escape and metastasis

Yang Liu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

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Article Oncology

Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells

Melanie R. Power Coombs et al.

CANCER LETTERS (2016)

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Article Oncology

Resveratrol Prevents Tumor Growth and Metastasis by Inhibiting Lymphangiogenesis and M2 Macrophage Activation and Differentiation in Tumor-ssociated Macrophages

Yoshiyuki Kimura et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)

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Article Immunology

Immunogenic Cell Death Induced by Ginsenoside Rg3: Significance in Dendritic Cell-based Anti-tumor Immunotherapy

Keum-Joo Son et al.

IMMUNE NETWORK (2016)

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Review Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

Jamie Rossjohn et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

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Article Immunology

Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-κB and PI3K/Akt/mTOR pathways

Yao Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

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Article Biochemistry & Molecular Biology

Regulatory Effect of Astragalus Polysaccharides on Intestinal Intraepithelial γδT Cells of Tumor Bearing Mice

Shuyu Sun et al.

MOLECULES (2014)

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Article Oncology

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

Ji-Young Jang et al.

BMC CANCER (2013)

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Review Genetics & Heredity

The metastasis-promoting roles of tumor-associated immune cells

Heath A. Smith et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

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Article Plant Sciences

Triptolide Downregulates Treg Cells and the Level of IL-10, TGF-β, and VEGF in Melanoma-Bearing Mice

Biao Liu et al.

PLANTA MEDICA (2013)

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Article Agriculture, Multidisciplinary

Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of γ-Interferon-Induced JAK-PKC-δ-STAT1 Signaling in Human Oral Cancer Cells

Chieh-Wen Cheng et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

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Article Oncology

Triptolide inhibits interferon-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells

Mei Liang et al.

CANCER LETTERS (2008)

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Article Hematology

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

X Chen et al.

BLOOD (2005)

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