Open Sesame to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer

Review Oncology

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

Christian L. Flugel et al.

Summary: CAR T cells targeting solid tumour antigens carry a higher risk of on-target, off-tumour toxicity (OTOT), and this article summarizes the available data on OTOT and describes novel CAR T cell designs to overcome such toxicities.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

Add to Collection

Article Cell Biology

The downregulation of type I IFN signaling in G-MDSCs under tumor conditions promotes their development towards an immunosuppressive phenotype

Yingying Sun et al.

Summary: Tumors can modify myeloid cell differentiation and induce an immunosuppressive microenvironment. Granulocytic myeloid-derived suppressor cells (G-MDSCs), which are immature myeloid cells with immunosuppressive activity, exist in tumor-bearing hosts. This study reveals that the increase of granulocyte colony-stimulating factor (G-CSF) in mouse serum promotes G-MDSCs to obtain immunosuppressive traits in peripheral blood through the PI3K-Akt/mTOR pathway. Additionally, downregulation of type I interferon (IFN-I) signaling in G-MDSCs is a prerequisite for their immunosuppressive effects.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Multidisciplinary Sciences

TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy

Salyan Bhattarai et al.

Summary: The authors of this study investigate the trained immunity of immune cells in Duchenne Muscular Dystrophy (DMD) and identify TLR4 as a key regulator of this process. Trained immunity contributes to dysregulated inflammation in DMD, and this mechanism is dependent on functional and epigenetic changes in TLR4 and bone marrow-derived macrophages.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Multidisciplinary Sciences

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

Nourhan Abdelfattah et al.

Summary: This study identifies molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and discovers S100A4 as a regulator of immune suppressive T and myeloid cells in GBM. The study reveals extensive spatial and molecular heterogeneity in immune infiltrates and identifies nine distinct myeloid cell subtypes, with five being prognostic indicators of glioma patient survival.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Repolarization of Tumor-Infiltrating Myeloid Cells for Augmentation of CAR T Cell Therapies

Weichuan Luo et al.

Summary: CAR T cell therapies have shown great effectiveness in treating hematopoietic cancers, but their success in solid tumors has been limited. This study investigates the role of immunosuppressive tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in CAR T cell therapy and proposes a method to enhance their efficacy by reprogramming these myeloid cells.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Immunology

LPS Guides Distinct Patterns of Training and Tolerance in Mast Cells

Marco De Zuani et al.

Summary: Mast cells are important innate immune cells that can sense and respond to different stimuli. Studies have shown that mast cells can develop immunological memory, and their responses can be shaped by different stimulatory environments.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Oncology

Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer

Francesco De Sanctis et al.

Summary: PDAC tumors exhibit strong immunosuppressive characteristics that limit the success of immunotherapy. Research shows that reprogramming the tumor microenvironment by intervening in RNS production can enhance the efficacy of immune-based treatments.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Add to Collection

Article Medicine, General & Internal

Fusobacterium nucleatum induces MDSCs enrichment via activation the NLRP3 inflammosome in ESCC cells, leading to cisplatin resistance

Mengxia Liang et al.

Summary: Fn infection can lead to high expression of NLRP3 and enrichment of MDSCs in ESCC, resulting in shortened survival time and resistance to CDDP in ESCC cells.

ANNALS OF MEDICINE (2022)

Add to Collection

Article Oncology

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis

Sergio Ortiz-Espinosa et al.

Summary: This study reveals that C5a can enhance the capacity of PMN-MDSCs to promote tumor growth and metastasis by inducing the formation of NETs. The formation of NETs is dependent on the production of HMGB1 by cancer cells. Inhibiting C5a, C5aR1, or NETosis can reduce the number of circulating tumor cells and the metastatic burden in a mouse lung metastasis model. The translational relevance of these findings is supported by the stimulation of migration and NETosis in PMN-MDSCs obtained from lung cancer patients.

CANCER LETTERS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Type I interferon-mediated tumor immunity and its role in immunotherapy

Renren Yu et al.

Summary: Type I interferons inhibit tumor growth directly and indirectly by acting upon tumor and immune cells, with evidence showing that enhancing both endo- and exogenously produced type I IFNs have a synergistic effect on anti-tumor immunity. Clinical trials are currently exploring new treatment strategies combining type I IFN inducers with ICBs, highlighting the importance of understanding the cellular sources and roles of type I IFNs in the immune regulation of the tumor microenvironment.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Add to Collection

Review Oncology

B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome

Wolf H. Fridman et al.

Summary: B cells play a critical role in the tumor microenvironment, particularly within tertiary lymphoid structures (TLS). The presence of mature TLS, high density of B cells and plasma cells, and antibodies targeting tumor-associated antigens are associated with favorable clinical outcomes and response to immunotherapy. However, polyclonal B cell activation can lead to pro-inflammatory responses. Novel therapeutic approaches are being explored to enhance the development of TLS and anti-tumor B cells for cancer therapy.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Add to Collection

Article Chemistry, Medicinal

Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

Isak W. Tengesdal et al.

Summary: The study reveals the significant role of the NLRP3 inflammasome in metastatic breast cancer, with NLRP3 activation being a key driver of immune suppression. Inhibiting NLRP3 can reduce tumor growth, increase survival, and decrease infiltration of MDSCs in the tumor microenvironment.

PHARMACEUTICALS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition

Chandra C. Ghosh et al.

Summary: Regional infusion of TLR9 agonists can eliminate liver metastasis-induced MDSCs and reprogram residual cells. It also increases the M1/M2 macrophage ratio. This method is more effective than systemic infusion and enhances TLR9 signaling.

CANCER GENE THERAPY (2022)

Add to Collection

Article Oncology

Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis

Zhiyong Zhang et al.

Summary: The study reveals that C. tropicalis promotes the development of colorectal cancer by enhancing the immunosuppressive function of MDSCs. This is achieved through multiple signaling pathways and metabolic reprogramming. These findings shed light on the role of gut fungi in the pathogenesis of colorectal cancer.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2022)

Add to Collection

Article Immunology

Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression

Iosif Papafragkos et al.

Summary: The NLRP3 inflammasome plays an important role in the functional properties of MDSCs in tumor-bearing hosts, and targeting NLRP3 may overcome tumor-induced tolerance and provide new checkpoints for cancer immunotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Oncology

Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells

Mi He et al.

Summary: TL8-506 in combination with IFN-γ or Poly(I:C) can activate human tumor-associated dendritic cells (DCs), inducing the expression of chemokines and cytokines, and enhancing the immunostimulatory capacity of DCs. This finding provides new insights for the research and development of cancer immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Add to Collection

Article Gastroenterology & Hepatology

Helicobacter pylori actively suppresses innate immune nucleic acid receptors

Samuel D. R. Dooyema et al.

Summary: In this study, a novel mechanism was identified through which H. pylori actively suppresses STING and RIG-I signaling via downregulation of IRF3 activation, which not only regulates the initial innate immune response, but also drives chronic gastric inflammation and injury.

GUT MICROBES (2022)

Add to Collection

Article Medicine, Research & Experimental

Manufacturing-dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development

Neeltje Steeghs et al.

Summary: This study evaluated the safety and efficacy of GSK1795091, a Toll-like receptor 4 (TLR4) agonist, in combination with immunotherapy in patients with solid tumors. The modified formulation of GSK1795091 showed changes in biological activity compared to the original formulation, but the safety profile was similar between the two formulations.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2022)

Add to Collection

Article Immunology

TLR2 agonist promotes myeloid-derived suppressor cell polarization via Runx1 in hepatocellular carcinoma

Shinan Li et al.

Summary: In this study, Pam3CSK4 injection was found to attenuate tumor growth, decrease MDSCs, and restore T cell function; Pam3CSK4 promoted MDSC polarization by targeting Runx1, while a Runx1 inhibitor reversed this effect; TLR2 and Runx1 play critical roles in regulating the differentiation and function of MDSCs, potentially through the ferroptosis pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Review Immunology

Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy

Bettina Hoden et al.

Summary: Innate immune response mechanisms play a crucial role in lung cancer immunity and immunotherapy. TLR signaling can modulate the tumor microenvironment and enhance the immune sensitization of tumor cells to treatments.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer

Dhifaf Sarhan et al.

Summary: Immunotherapy for cancer has revolutionized the treatment of previously lethal cancers, but its efficacy in pancreatic ductal adenocarcinoma (PDAC) has been disappointing. This study shows that the expression of scavenger receptor MARCO is associated with poor prognosis and a tumor phenotype that excludes lymphocytes. Targeting MARCO can remodel the tumor microenvironment and improve the efficiency of immunotherapy in PDAC patients.

ISCIENCE (2022)

Add to Collection

Article Chemistry, Applied

A polysaccharide from native Curcuma kwangsiensis and its mechanism of reversing MDSC-induced suppressive function

Siliang Jiang et al.

Summary: nCKAP-2, a purified polysaccharide extracted from Curcuma kwangsiensis, exhibits bioactivity by reversing the suppressive function of myeloid-derived suppressor cells (MDSCs) on T cells. Further study reveals that nCKAP-2 induces apoptotic cell death in MDSCs via a specific pathway and signaling pathway, along with a reduction in ROS levels.

CARBOHYDRATE POLYMERS (2022)

Add to Collection

Review Oncology

Context-dependent functions of pattern recognition receptors in cancer

Si Ming Man et al.

Summary: The immune system plays a critical role in cancer, and while the importance of adaptive immunity has been recognized and utilized in immunotherapy, the potential of innate immunity has not been fully exploited. Pattern recognition receptors (PRRs) have emerged as key regulators in the immune response to cancer, both in immune cells and cancer cells. Targeting PRRs shows promise in cancer drug development and biomarker discovery.

NATURE REVIEWS CANCER (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression

Caitlyn L. Miller et al.

Summary: Conjugating an immunostimulant with a tumor-targeted peptide improves the efficacy of systemically administered immunotherapy, transforming the immune-suppressive tumor microenvironment into a lymphocyte-rich environment. Furthermore, this treatment generates tumor-specific CD8(+)T cells.

CELL CHEMICAL BIOLOGY (2022)

Add to Collection

Article Oncology

NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma

Fei Lu et al.

Summary: The study revealed that NLRP3 inflammasome promotes immunosuppression in lymphoma by modulating PD-L1 and immune cells. Blockade of NLRP3 inflammasome can suppress lymphoma growth and improve anti-tumor immunity.

CANCER LETTERS (2021)

Add to Collection

Article Immunology

Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors

Fatma Babikr et al.

Summary: IRE + Combo is a promising strategy to improve the therapeutic effects of IRE ablation therapy in cancer, by inducing more effective immune responses and promoting conversion of the tumor microenvironment.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection

Review Oncology

Dual roles of myeloid-derived suppressor cells induced by Toll-like receptor signaling in cancer

Hongyue Zhou et al.

Summary: Myeloid-derived suppressor cells (MDSCs) are key components of the tumor microenvironment (TME) and play a significant role in tumor-induced immunosuppression. Recent studies have shown that Toll-like receptor (TLR) signaling pathway affects the survival, differentiation, and immunosuppressive activity of MDSCs, with potential implications for cancer immunotherapy. The regulatory effects of TLR signaling on MDSCs remain controversial, as TLR-induced MDSCs can acquire different immunosuppressive activities that may either benefit or harm cancer immunotherapy efforts.

ONCOLOGY LETTERS (2021)

Add to Collection

Article Cell Biology

Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells

Charles Maisonneuve et al.

Summary: The pioneering studies in the early 1980s indicated that bacterial peptidoglycan-derived muramyl peptides (MPs) have dual functions of either stimulation or immunosuppression depending on the chronicity of exposure. This study demonstrates the immunosuppressive potential of Nod1, the bacterial sensor of diaminopimelic acid (DAP)-containing MPs, in reprogramming macrophages and inducing myeloid-derived suppressor cells (MDSCs) to maintain their immunosuppressive activity, ultimately promoting tumor progression in colorectal cancer.

CELL REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme

Elisa Jentho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Multidisciplinary Sciences

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Isak W. Tengesdal et al.

Summary: NLRP3 inflammasome activation in melanoma promotes tumor growth and progression while suppressing immune response. Inhibiting NLRP3 can reduce the expansion of MDSCs, enhance antitumor immunity, and slow down tumor growth.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Multidisciplinary Sciences

Deciphering the state of immune silence in fatal COVID-19 patients

Pierre Bost et al.

Summary: COVID-19 patients show unique immune features, including lung accumulation of naive lymphoid cells, systemic expansion and activation of myeloid cells, and immune suppression. Loss of monocyte-driven and neutrophil-driven immune suppression may lead to fatal outcomes in severe patients. On the other hand, a lung CXCR6(+) effector memory T cell subset may be associated with better prognosis in severe COVID-19 patients.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Immunology

TLR Agonists as Mediators of Trained Immunity: Mechanistic Insight and Immunotherapeutic Potential to Combat Infection

Allison M. Owen et al.

Summary: Despite improvements in critical care medicine, infection remains a significant challenge, especially for immunocompromised patients who are highly susceptible to severe infection leading to sepsis. Activation of the innate immune system, particularly through the phenomenon of trained immunity, shows promise in enhancing host immune defenses. Toll-like receptor (TLR) agonists have been identified as agents capable of inducing trained immunity through metabolic and epigenetic modifications, offering potential as immunotherapeutic agents in combatting infection.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Immunology

STAT3 Silencing and TLR7/8 Pathway Activation Repolarize and Suppress Myeloid-Derived Suppressor Cells From Breast Cancer Patients

Elham Safarzadeh et al.

Summary: The study found that the levels of HLA-DR(-)CD33(+) MDSCs in the blood of breast cancer patients are elevated, and these cells can strongly suppress T cell proliferation and enter the tumor microenvironment. Inhibiting the STAT3 signaling pathway and activating the TLR7/8 pathway can reduce the immunosuppressive effects of patient-derived MDSCs on T cells and decrease breast cancer cell proliferation.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Oncology

Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic

Amit Grover et al.

Summary: MDSCs are important regulators of immune responses in cancer, and their association with negative clinical outcomes makes them attractive therapeutic targets. However, the complex nature of MDSC biology presents a substantial challenge for therapeutic targeting. This review discusses the challenges and potential solutions in targeting MDSCs for therapeutic intervention.

CANCER DISCOVERY (2021)

Add to Collection

Article Oncology

Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy

Pascale Hubert et al.

Summary: In this study, it was demonstrated that targeting extracellular HMGB1 can significantly remodel the tumor immune microenvironment for more effective cancer therapy. Inhibition of HMGB1 led to reductions in immunosuppressive cells, such as myeloid-derived suppressor cells and regulatory T lymphocytes, while also enhancing the activation of immune cells like dendritic cells. Additionally, blocking HMGB1 improved the efficacy of anti-PD-1 cancer immunotherapy, suggesting that extracellular HMGB1 blockade could enhance current cancer immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Add to Collection

Review Oncology

Role of Tumor-Associated Macrophages in Sarcomas

Tomohiro Fujiwara et al.

Summary: Recent studies have highlighted the pro-tumoral role of TAMs in sarcomas, and drugs targeting TAMs may represent a novel therapeutic approach for bone and soft-tissue sarcomas. Promising results from clinical trials of TAM-targeted therapies warrant further investigation into their potential benefits for sarcoma patients.

CANCERS (2021)

Add to Collection

Review Cell Biology

A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment

Francesca Hofer et al.

Summary: Research has shown that myeloid-derived suppressor cells play a crucial role in immune regulation within the tumor microenvironment, with their metabolic pathways and functions being essential for cancer progression.

CELLS (2021)

Add to Collection

Article Oncology

Exosomes Derived from RM-1 Cells Promote the Recruitment of MDSCs into Tumor Microenvironment by Upregulating CXCR4 via TLR2/NF-κB Pathway

Nan Li et al.

Summary: Prostate cancer-derived exosomes enhance CXCR4 expression in MDSCs via the TLR2/NF-kappa B signaling pathway, promoting the migration of MDSCs into tumor microenvironment in a CXCR4-CXCL12 axis-dependent manner.

JOURNAL OF ONCOLOGY (2021)

Add to Collection

Article Cell Biology

Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling

Hui Liu et al.

Summary: Tumor recurrence is a major obstacle for liver transplantation in HCC patients, with inflammatory cascades promoting recurrence. The mobilization of MDSC induced by liver graft injury plays a role in promoting HCC recurrence. Targeting MDSC mobilization via CXCL10/TLR4/MMP14 signaling may represent a potential therapeutic approach to decrease post-transplant liver tumor recurrence.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Oncology

Targeting the MDSCs of Tumors In Situ With Inhibitors of the MAPK Signaling Pathway to Promote Tumor Regression

Jiayun Yu et al.

Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment. The MAPK pathways are significantly increased in tumor MDSCs and their inhibition can induce MDSC apoptosis, leading to tumor growth inhibition and alterations in the immune cell composition within the tumor microenvironment.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

Lexus R. Johnson et al.

Summary: In this study, engineering CAR-T cells to deliver RN7SL1 promotes CAR-T cell proliferation and enhances effector-memory differentiation, while inhibiting MDSC development and increasing DC subsets, thereby boosting endogenous immunity and rejecting solid tumors lacking CAR antigens.

CELL (2021)

Add to Collection

Article Immunology

Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells

Sho Hangai et al.

Summary: Cell death in cancer therapies is often associated with immunogenicity, but the study by Taniguchi and colleagues reveals that release of TCTP following cell death triggers an immunosuppressive pathway in the tumor microenvironment. Inhibiting TCTP can suppress MDSC accumulation and tumor growth, offering a new rationale for cancer immunotherapy. The study provides a better understanding of the dynamics in MDSC accumulation in the tumor microenvironment, with implications for developing new cancer therapeutics.

NATURE IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer

Natalia Palazon-Carrion et al.

Summary: This study analyzed immune biomarkers in peripheral blood of patients with advanced breast cancer undergoing antineoplastic therapy, finding higher levels of myeloid derived suppressor cells and regulatory T cells in patients compared to healthy women. Patients with clinical benefit showed an increase in activated T lymphocytes and a decrease in immune inhibitory cells, while those with disease progression exhibited the opposite trend. These results suggest detectable immune elements in peripheral blood may be correlated with clinical evolution in advanced breast cancer.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Oncology

A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2/NLRP3-Mediated M1-Like TAMs

Lina Fan et al.

Summary: The study identified a link between reduced abundance of A. muciniphila and colorectal cancer; supplementation with A. muciniphila suppressed colonic tumorigenesis; A. muciniphila induced M1-like macrophages may serve as a therapeutic target in the colorectal cancer tumor microenvironment.

CANCER IMMUNOLOGY RESEARCH (2021)

Add to Collection

Article Immunology

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Isak W. Tengesdal et al.

Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

Therapeutic Induction of Tertiary Lymphoid Structures in Cancer Through Stromal Remodeling

Anna Johansson-Percival et al.

Summary: Improving the effectiveness of anti-cancer immunotherapy is a major clinical challenge due to the suppressive tumor microenvironment. The presence of tertiary lymphoid structures (TLS) in some human cancers is associated with better prognosis and responsiveness to immune checkpoint blockade. Inducing and shaping TLS in the tumor microenvironment could provide innovative opportunities to enhance immunotherapies.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

Wendi Kang et al.

Summary: TLSs play a vital role in the tumor microenvironment and are closely associated with favorable clinical outcomes in most types of cancers, though there are some studies reporting an association with a poor prognosis. Further investigation into their double-edged sword role and potential mechanisms is needed to provide novel therapeutic perspectives for antitumor immunoregulation.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma

Ning Wang et al.

Summary: The altered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment, and PIWIL1 plays a critical role in mediating the crosstalk between fatty acid metabolism and immune response in HCC. Overexpression of PIWIL1 promotes HCC proliferation and growth by enhancing fatty acid metabolism and attracting MDSCs into the tumor microenvironment. Targeting PIWIL1 may offer a potential novel treatment strategy for HCC.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Oncology

TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages

Zhipeng Liu et al.

CANCER LETTERS (2020)

Add to Collection

Review Oncology

The Engagement Between MDSCs and Metastases: Partners in Crime

Rosalinda Trovato et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection

Article Oncology

Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs

Chiara Porta et al.

CANCER RESEARCH (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Toll-like Receptors and the Control of Immunity

Katherine A. Fitzgerald et al.

CELL (2020)

Add to Collection

Article Immunology

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

Eslam Mohamed et al.

IMMUNITY (2020)

Add to Collection

Review Oncology

Toll-Like Receptor Agonists and Radiation Therapy Combinations: An Untapped Opportunity to Induce Anticancer Immunity and Improve Tumor control

Richard C. Walshaw et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Add to Collection

Article Medicine, Research & Experimental

A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy

Balamayoora Theivanthiran et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Add to Collection

Article Immunology

MDSC subtypes and CD39 expression on CD8+T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC

Jiae Koh et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

Add to Collection

Article Oncology

Palmitoylated Proteins on AML-Derived Extracellular Vesicles Promote Myeloid-Derived Suppressor Cell Differentiation via TLR2/Akt/mTOR Signaling

Sehmus Tohumeken et al.

CANCER RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Jonas Schulte-Schrepping et al.

CELL (2020)

Add to Collection

Article Cell Biology

Renal cancer-derived exosomes induce tumor immune tolerance by MDSCs-mediated antigen-specific immunosuppression

Yingying Gao et al.

CELL COMMUNICATION AND SIGNALING (2020)

Add to Collection

Article Immunology

Peptide vaccine with glucopyranosyl lipid A-stable oil-in-water emulsion for patients with resected melanoma

Eric P. Grewal et al.

IMMUNOTHERAPY (2020)

Add to Collection

Article Oncology

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

Chuan-xia Zhang et al.

ONCOGENESIS (2020)

Add to Collection

Article Oncology

Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

Hao Cheng et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection

Article Cell Biology

Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects

Xiao-yan Zhou et al.

MEDIATORS OF INFLAMMATION (2020)

Add to Collection

Article Multidisciplinary Sciences

Tumor repolarization by an advanced liposomal drug delivery system provides a potent new approach for chemo-immunotherapy

L. Ringgaard et al.

SCIENCE ADVANCES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Interactions between tumor-derived proteins and Toll-like receptors

Gun-Young Jang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Cell Biology

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Simone J. C. F. M. Moorlag et al.

CELL REPORTS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Lydia Kalafati et al.

CELL (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

Chuan-xia Zhang et al.

CELL DEATH AND DIFFERENTIATION (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

Julien Cherfils-Vicini et al.

EMBO JOURNAL (2019)

Add to Collection

Article Oncology

CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production

Junxing Qu et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Add to Collection

Article Oncology

Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling

Viktor Fleming et al.

CANCER RESEARCH (2019)

Add to Collection

Review Immunology

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Triantafyllos Chavakis et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Article Cell Biology

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment

Adelie Dumont et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Oncology

Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression

Wenwen Xu et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Add to Collection

Review Immunology

Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity

Graham Pawelec et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Virology

Endosomal Toll-Like Receptors Mediate Enhancement of Interleukin-17A Production Triggered by Epstein-Barr Virus DNA in Mice

Marwa Shehab et al.

JOURNAL OF VIROLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

TLR1/TLR2 signaling blocks the suppression of monocytic myeloid-derived suppressor cell by promoting its differentiation into M1-type macrophage

Yuting Deng et al.

MOLECULAR IMMUNOLOGY (2019)

Add to Collection

Article Immunology

S100A9 Regulates MDSCs-Mediated Immune Suppression via the RAGE and TLR4 Signaling Pathways in Colorectal Carcinoma

Mao Huang et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Oncology

Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

Rosalinda Trovato et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Add to Collection

Article Oncology

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

Philipp Metzger et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Add to Collection

Article Oncology

Carbohydrate-based adjuvants activate tumor-specific Th1 and CD8+ T-cell responses and reduce the immunosuppressive activity of MDSCs

Xiaojing Xu et al.

CANCER LETTERS (2019)

Add to Collection

Article Immunology

Caveolin-1 Controls Vesicular TLR2 Expression, p38 Signaling and T Cell Suppression in BCG Infected Murine Monocytic Myeloid-Derived Suppressor Cells

Vini John et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Cell Biology

TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells

Yushe Dang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2018)

Add to Collection

Article Oncology

Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade

Jorrit De Waele et al.

ONCOIMMUNOLOGY (2018)

Add to Collection

Article Oncology

Toll-like receptor 2 ligand and interferon-gamma suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

Hiroaki Shime et al.

ONCOIMMUNOLOGY (2018)

Add to Collection

Article Oncology

Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay

Marilena Gallotta et al.

CANCER RESEARCH (2018)

Add to Collection

Article Biochemistry & Molecular Biology

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Eva Kaufmann et al.

CELL (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Siroon Bekkering et al.

CELL (2018)

Add to Collection

Article Immunology

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

Yuki Katayama et al.

JOURNAL OF IMMUNOLOGY (2018)

Add to Collection

Article Chemistry, Medicinal

Salutaxel, a Conjugate of Docetaxel and a Muramyl Dipeptide (MDP) Analogue, Acts as Multifunctional Prodrug That Inhibits Tumor Growth and Metastasis

Xiaoming Wen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Add to Collection

Review Immunology

Myeloid-derived suppressor cells coming of age

Filippo Veglia et al.

NATURE IMMUNOLOGY (2018)

Add to Collection

Article Immunology

Hyperthermic treatment at 56 °C induces tumour-specific immune protection in a mouse model of prostate cancer in both prophylactic and therapeutic immunization regimens

Francesco De Sanctis et al.

VACCINE (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Bacillus Calmette-Guerin and anti-PD-LI combination therapy boosts immune response against bladder cancer

Yonghua Wang et al.

ONCOTARGETS AND THERAPY (2018)

Add to Collection

Article Multidisciplinary Sciences

The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas P. D. Liau et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Immunology

S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4-ERK1/2 Signaling

Qingcui Li et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Oncology

Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck The Active8 Randomized Clinical Trial

Robert L. Ferris et al.

JAMA ONCOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Induction of immunosuppressive functions and NF-kappa B by FLIP in monocytes

Alessandra Fiore et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Oncology

Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals

Gulidanna Shayan et al.

CLINICAL CANCER RESEARCH (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+ Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway

Hiroaki Shime et al.

CELL DEATH AND DIFFERENTIATION (2017)

Add to Collection

Article Oncology

Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy

Bradley J. Monk et al.

CLINICAL CANCER RESEARCH (2017)

Add to Collection

Article Oncology

The TLR3 Agonist Inhibit Drug Efflux and Sequentially Consolidates Low-Dose Cisplatin-Based Chemoimmunotherapy while Reducing Side Effects

Liang Ding et al.

MOLECULAR CANCER THERAPEUTICS (2017)

Add to Collection

Article Immunology

Calreticulin Fragment 39-272 Promotes B16 Melanoma Malignancy through Myeloid-Derived Suppressor Cells In Vivo

Xiao-Yan He et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Oncology

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

Andrea Facciabene et al.

ONCOIMMUNOLOGY (2017)

Add to Collection

Article Oncology

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

Alexander Martens et al.

CLINICAL CANCER RESEARCH (2016)

Add to Collection

Article Oncology

Clinical Significance of Circulating CD33+ CD11b+HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab

Moshe Sade-Feldman et al.

CLINICAL CANCER RESEARCH (2016)

Add to Collection

Article Immunology

Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer

Sabrin H. Albeituni et al.

JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Damage-associated molecular patterns in cancer: a double-edged sword

C. Hernandez et al.

ONCOGENE (2016)

Add to Collection

Review Medicine, General & Internal

NOD-Like Receptors in Infection, Immunity, and Diseases

Young Keun Kim et al.

YONSEI MEDICAL JOURNAL (2016)

Add to Collection

Review Multidisciplinary Sciences

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte et al.

NATURE COMMUNICATIONS (2016)

Add to Collection

Article Oncology

Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer

Jinhoi Song et al.

ONCOTARGET (2016)

Add to Collection

Article Oncology

TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function

Thibaud Spinetti et al.

ONCOIMMUNOLOGY (2016)

Add to Collection

Article Medicine, General & Internal

Sepsis and septic shock

Richard S. Hotchkiss et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Add to Collection

Article Microbiology

Tumor-Induced Myeloid-Derived Suppressor Cells

Francesco De Sanctis et al.

MICROBIOLOGY SPECTRUM (2016)

Add to Collection

Article Immunology

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

Thomas Condamine et al.

SCIENCE IMMUNOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling

Akira Maruyama et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Add to Collection

Article Oncology

TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity

Degui Geng et al.

CANCER RESEARCH (2015)

Add to Collection

Article Oncology

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients

Dewan M. S. Hossain et al.

CLINICAL CANCER RESEARCH (2015)

Add to Collection

Article Immunology

Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway

Yi Liu et al.

IMMUNOLOGY (2015)

Add to Collection

Review Medicine, Research & Experimental

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

Stefano Ugel et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Add to Collection

Article Immunology

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

Constantinos P. Zambirinis et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection

Article Immunology

Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells

Jing Wang et al.

JOURNAL OF IMMUNOLOGY (2015)

Add to Collection

Article Chemistry, Medicinal

Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells

Moonkyu Lee et al.

ARCHIVES OF PHARMACAL RESEARCH (2014)

Add to Collection

Article Oncology

Correlation between frequencies of blood monocytic myeloid-derived suppressor cells, regulatory T cells and negative prognostic markers in patients with castration-resistant metastatic prostate cancer

Manja Idorn et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)

Add to Collection

Article Immunology

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

Hongliang Fang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2014)

Add to Collection

Review Immunology

Phagocytosis: receptors, signal integration, and the cytoskeleton

Spencer A. Freeman et al.

IMMUNOLOGICAL REVIEWS (2014)

Add to Collection

Article Oncology

Phase 2, open-label, 1:1 randomized controlled trial exploring the efficacy of EMD 1201081 in combination with cetuximab in second-line cetuximab-na⟨ve patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)

A. Ruzsa et al.

INVESTIGATIONAL NEW DRUGS (2014)

Add to Collection

Article Medicine, Research & Experimental

Targeting TLR-4 with a novel pharmaceutical grade plant derived agonist, Immunomax®, as a therapeutic strategy for metastatic breast cancer

Anahit Ghochikyan et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Add to Collection

Article Oncology

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

Dinesh Chandra et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Add to Collection

Article Oncology

Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients

Ang Huang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

Add to Collection

Article Immunology

β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells

Jie Tian et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

Add to Collection

Article Oncology

LPS converts Gr-1+CD115+ myeloid-derived suppressor cells from M2 to M1 via P38 MAPK

Yi Yang et al.

EXPERIMENTAL CELL RESEARCH (2013)

Add to Collection

Article Immunology

The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter

Uzma A. Hasan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

Melanie Bruchard et al.

NATURE MEDICINE (2013)

Add to Collection

Review Immunology

Functions of NOD-like receptors in human diseases

Yifei Zhong et al.

FRONTIERS IN IMMUNOLOGY (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Recognition of lipopolysaccharide pattern by TLR4 complexes

Beom Seok Park et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2013)

Add to Collection

Article Immunology

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8+ T-cell responses in melanoma patients

Simone M. Goldinger et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2012)

Add to Collection

Article Multidisciplinary Sciences

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Oncology

CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

Christine Zoglmeier et al.

CLINICAL CANCER RESEARCH (2011)

Add to Collection

Article Oncology

Increased Lung Cancer Risk among Patients with Pulmonary Tuberculosis A Population Cohort Study

Yang-Hao Yu et al.

JOURNAL OF THORACIC ONCOLOGY (2011)

Add to Collection

Article Multidisciplinary Sciences

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

June L. Round et al.

SCIENCE (2011)

Add to Collection

Article Oncology

The Inflammasome Component Nlrp3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-Associated Myeloid-Derived Suppressor Cells

Hendrik W. van Deventer et al.

CANCER RESEARCH (2010)

Add to Collection

Review Immunology

Intracellular Toll-like Receptors

Amanda L. Blasius et al.

IMMUNITY (2010)

Add to Collection

Article Immunology

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

Ilaria Marigo et al.

IMMUNITY (2010)

Add to Collection

Article Oncology

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

Joshua D. Brody et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Add to Collection

Review Immunology

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Taro Kawai et al.

NATURE IMMUNOLOGY (2010)

Add to Collection

Review Pharmacology & Pharmacy

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity

Paola M. Barral et al.

PHARMACOLOGY & THERAPEUTICS (2009)

Add to Collection

Article Immunology

Modulation of the antitumor immune response by complement

Maciej M. Markiewski et al.

NATURE IMMUNOLOGY (2008)

Add to Collection

Review Immunology

Toll-like receptor signalling

S Akira et al.

NATURE REVIEWS IMMUNOLOGY (2004)

Add to Collection

Open Sesame to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer

Related references