Journal
FRONTIERS IN IMMUNOLOGY
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2023.1120519
Keywords
ferroptosis; lipid metabolism; reactive oxygen species biology; iron homeostasis; immunity; autoimmune diseases
Categories
Ask authors/readers for more resources
This review summarizes recent advancements in the interaction between ferroptosis and the immune system, with a focus on autoimmune diseases. It provides a comprehensive understanding of the critical regulators of ferroptosis and highlights the molecular crosstalk between ferroptosis and different immune cells. Future research is expected to uncover the mechanisms governing ferroptosis and explore its therapeutic potential in autoimmune diseases.
Ferroptosis, a novel type of regulated cell death mediated by iron-dependent lipid oxidation, was discovered a decade ago. Significant progress has been made in our knowledge of ferroptosis and immune dysfunction. This review covers recent advancements in the interaction of ferroptosis and the immune system, with an emphasis on autoimmune diseases. The critical regulators of ferroptosis are summarized in the context of reactive oxygen species biology, lipid metabolism, and iron homeostasis. The molecular crosstalk between ferroptosis and different immune cells is also highlighted. Future research is expected to yield new insights into the mechanisms governing ferroptosis and its potential therapeutic benefits in autoimmune diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available