4.8 Review

Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

Related references

Note: Only part of the references are listed.
Article Microbiology

LysX2 is a Mycobacterium tuberculosis membrane protein with an extracytoplasmic MprF-like domain

Francesca Boldrin et al.

Summary: In this study, we characterized a protein encoded by the Mtb genome, Rv1619, and found that it is a potential member of the aaPG synthase family. Unlike previous studies, we predicted that the MprF-like domain of Rv1619 is located in the extracytoplasmic region.

BMC MICROBIOLOGY (2022)

Review Biochemistry & Molecular Biology

Taming the Devil: Antimicrobial Peptides for Safer TB Therapeutics

Krishna Jadhav et al.

Summary: Tuberculosis is a highly contagious infection with increasing drug-resistant strains. Antimicrobial peptides have shown promise in killing TB bacteria and biofilms, but also have limitations. Combinatorial therapies and drug delivery systems may offer new possibilities in TB treatment.

CURRENT PROTEIN & PEPTIDE SCIENCE (2022)

Review Chemistry, Physical

Advances in Nanostructures for Antimicrobial Therapy

Josef Jampilek et al.

Summary: Due to the prevalence of drug-resistant microorganisms, there is a decreasing number of new antimicrobial drugs capable of combating these strains. Therefore, formulation innovations and nanotechnologies offer promising alternatives to improve the effectiveness of existing antimicrobial drugs.

MATERIALS (2022)

Review Immunology

In the Thick of It: Formation of the Tuberculous Granuloma and Its Effects on Host and Therapeutic Responses

Mark R. Cronan

Summary: This review discusses the signals and cellular reprogramming involved in granuloma formation, as well as how the granuloma shapes the outcome of tuberculosis by altering immune responses and bacterial susceptibility to antibiotic treatment. The understanding of granuloma biology and signaling highlights the potential for host-directed therapies to improve antibiotic access and tuberculosis-specific immune responses.

FRONTIERS IN IMMUNOLOGY (2022)

Article Infectious Diseases

Antimicrobial Peptides: From Design to Clinical Application

Chunye Zhang et al.

Summary: Infection caused by multidrug-resistant bacteria is a significant public health concern and economic burden. Pathogenic bacteria have developed various mechanisms to resist antibiotics, and antibiotic resistance genes can be transferred between bacteria. Antimicrobial peptides (AMPs) have multiple killing mechanisms and can be potential alternatives to antibiotics. Strategies such as structural modification, amino acid substitution, and encapsulation with nanoparticles improve the efficacy and reduce toxicity of AMPs.

ANTIBIOTICS-BASEL (2022)

Article Biology

An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis

Kiel Hards et al.

Summary: Derivatives of the FDA-approved drug, amiloride, can eliminate drug-resistant Mycobacterium tuberculosis in vitro by interfering with bacterial energy conservation.

COMMUNICATIONS BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Plant Antimicrobial Peptides (PAMPs): Features, Applications, Production, Expression, and Challenges

Olalekan Olanrewaju Bakare et al.

Summary: This review examines the applications, features, production, expression, and challenges of plant antimicrobial peptides (PAMPs) and explores their significance in genomics, transcriptomics, proteomics, and their expression against pathogens. The review also highlights the potential therapeutic applications of PAMPs in medicine and agriculture, as well as their recyclability and conversion into more potent antimicrobial agents for sustainable development.

MOLECULES (2022)

Review Immunology

Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis

Matthew B. B. McNeil et al.

Summary: This review discusses the consequences of inhibiting multiple respiratory components of Mycobacterium tuberculosis and provides potential mechanisms for the strongest interactions. By highlighting interactions with alternative respiratory components, alternative proteins can be explored as potential drug targets and as part of unique drug combinations.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Chemistry, Medicinal

Anti-persister and Anti-biofilm Activity of Self-Assembled Antimicrobial Peptoid Ellipsoidal Micelles

Jennifer S. Lin et al.

Summary: This study aims to explore a new class of anti-persister drugs called peptoids and demonstrates that a specific antimicrobial peptoid can effectively eliminate persister cells and biofilms, as well as inhibit cytokine production induced by lipopolysaccharides.

ACS INFECTIOUS DISEASES (2022)

Review Immunology

Epigenetics in Tuberculosis: Immunomodulation of Host Immune Response

Avinash Khadela et al.

Summary: Tuberculosis is a highly challenging and chronic infection that requires the action of the host's immune system. Epigenetic modification plays a crucial role in the pathophysiology and treatment of tuberculosis, but there are still gaps in the research.

VACCINES (2022)

Review Infectious Diseases

Antimicrobial Peptides-Mechanisms of Action, Antimicrobial Effects and Clinical Applications

Jasminka Talapko et al.

Summary: The emergence of antimicrobial resistance is a global problem, and innovative therapeutic options are needed. Antimicrobial peptides have broad antimicrobial activity and lower propensity for resistance development, making them promising candidates for infectious disease treatment. However, their use in clinical practice presents challenges.

ANTIBIOTICS-BASEL (2022)

Article Infectious Diseases

Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

Su-Jin Kang et al.

Summary: Antimicrobial peptides (AMPs) have gained attention as potential alternatives to antibiotics due to their broad-spectrum antibiotic activities and different action mechanisms. However, their clinical applications are limited by issues such as enzymatic degradation, toxicity, and selectivity. This review focuses on the structural modifications of AMPs and the use of nanodelivery systems to overcome these limitations.

ANTIBIOTICS-BASEL (2022)

Review Biochemistry & Molecular Biology

Role of Antimicrobial Peptides in Treatment and Prevention of Mycobacterium Tuberculosis: A Review

Kanchan Mehta et al.

Summary: Tuberculosis (TB) is a global health emergency with high mortality rates. The current clinical interventions face challenges like low patient compliance and emerging antimicrobial resistance. There is a need for new anti-TB therapeutic agents that can enhance safety profiles, reduce therapy duration, and target drug resistant forms of TB. Antimicrobial peptides (AMPs) have been researched as potential antibiotics and therapeutics to combat infections and non-infectious diseases. This review provides information on the biological role, classification, and mode of action of AMPs against tuberculosis, as well as the prospects and challenges of developing peptides for therapeutic applications against Mycobacterium tuberculosis.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2022)

Review Engineering, Biomedical

Drug Delivery Systems for the Oral Administration of Antimicrobial Peptides: Promising Tools to Treat Infectious Diseases

Caroline Deshayes et al.

Summary: Antimicrobial peptides (AMPs) have the potential to combat antimicrobial resistance, but their oral administration is currently limited. Developing novel drug delivery systems could be a promising way to improve the oral bioavailability of AMPs.

FRONTIERS IN MEDICAL TECHNOLOGY (2022)

Review Microbiology

Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains

Davi de Lacerda Coriolano et al.

Summary: This study reviews the antibacterial and antibiofilm activity of silver nanoparticles (AgNPs) against Pseudomonas aeruginosa strains, showing promising potential for future therapeutic applications and efficacy against drug-resistant strains. AgNPs with smaller particle sizes have greater contact surface area with microorganisms, affecting their vital functioning. AgNPs adhere to the cytoplasmic membrane and cell wall of microorganisms, causing disruption, penetrating the cell, interacting with cellular structures, and inducing the generation of reactive oxygen species and free radicals.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Pharmacology & Pharmacy

Antimicrobial activity of synthetic antimicrobial peptides loaded in poly-ε-caprolactone nanoparticles against mycobacteria and their functional synergy with rifampicin

Ankur Sharma et al.

Summary: The treatment of tuberculosis is challenging due to the limitations of antibiotic effectiveness caused by the bacteria's lipid-rich cell wall and the development of resistance mutations. Antimicrobial peptides (AMPs) offer a new treatment strategy with promising potential when encapsulated in biocompatible polymers. This encapsulation method enhances antimicrobial activity and synergy with conventional antibiotics in combating mycobacteria.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Biochemistry & Molecular Biology

Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Areetha R. D'Souza et al.

Summary: This study examines the effect of replacing tryptophan with the non-natural amino acid Azulenyl-Alanine (AzAla) in antimicrobial peptides. The results show that this substitution preserves antimicrobial activity, improves cytocompatibility with human cells, and enhances proteolytic stability. AzAla is envisioned as a tool for studying AMP mechanisms and could enhance the application properties of AMP sequences.

BIOMOLECULES (2021)

Article Nanoscience & Nanotechnology

Synergistic and On-Demand Release of Ag-AMPs Loaded on Porous Silicon Nanocarriers for Antibacteria and Wound Healing

Yao Jin et al.

Summary: The study developed a dual synergistic antibacterial platform based on AgNPs and AMP, showing excellent antibacterial effect with on-demand release ability. PSiMPs as a carrier efficiently loaded AgNPs and AMP, releasing Ag+ and AMP under bacterial infection conditions, promoting wound healing by synergistic antibacterial efficiency.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Infectious Diseases

Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?

Krzesimir Ciura et al.

Summary: This study discusses the chromatographic experiments of three groups of related peptide substances to support the characterization of antimicrobial peptides. The results obtained through immobilized artificial membrane chromatography shed light on the mechanisms of action of these compounds. Despite efforts, commercial availability of peptide-based antimicrobials remains limited.

ANTIBIOTICS-BASEL (2021)

Article Multidisciplinary Sciences

Phospholipid translocation captured in a bifunctional membrane protein MprF

Danfeng Song et al.

Summary: MprF, a crucial family of membrane proteins in bacteria, enables pathogens like Staphylococcus aureus to acquire resistance to specific drugs and antimicrobial peptides. Cryo-EM structures of RtMprF in complex with LysPG reveal insights into the mechanisms of phospholipid modification and translocation.

NATURE COMMUNICATIONS (2021)

Review Chemistry, Medicinal

Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review

Gabriel S. Oliveira et al.

Summary: Despite being recognized as a public health emergency for the past 25 years, tuberculosis remains a major cause of mortality worldwide. The emergence of multidrug-resistant strains and challenges with existing treatments have prompted the search for alternative approaches, such as antimicrobial peptides, to combat the disease. Research into antimicrobial peptides as potential anti-tubercular agents has been driven by the increasing threat posed by resistant strains, the innate resistance of mycobacteria, and patient non-compliance with toxic treatments.

PHARMACEUTICALS (2021)

Article Microbiology

Anti-mycobacterial activity evaluation of designed peptides: cryptic and database filtering based approach

Sneha Raj et al.

Summary: Tuberculosis is a deadly airborne disease, leading to 10.4 million deaths annually. New therapeutic molecules are urgently needed to combat the toxicity of current drugs, rise in drug-resistant strains, and unique defense mechanisms of Mycobacterium tuberculosis. Host defense peptides show promise as alternative therapeutic candidates by targeting microbial membranes and being a crucial part of human innate immunity.

ARCHIVES OF MICROBIOLOGY (2021)

Review Immunology

Are Host Defense Peptides and Their Derivatives Ready to be Part of the Treatment of the Next Coronavirus Pandemic?

Bruno Rivas-Santiago et al.

Summary: Host defense peptides, initially named to refer to host immunity peptides, are now seen as a potential solution to combat drug-resistant microorganisms and emerging viruses like coronaviruses, due to their broad antimicrobial capacity and immunomodulatory activity. This review assesses whether these peptides and their derivatives are prepared to be part of the treatment for the next coronavirus pandemic, given the history of coronavirus outbreaks and pandemics in the 21st century.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2021)

Article Biochemistry & Molecular Biology

Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis

Reiner Noschka et al.

Summary: Gran1, a synthetic fragment of Granulysin, demonstrates efficient antimicrobial activity against Mycobacterium tuberculosis and clinically relevant non-tuberculous mycobacteria. It interacts with the surface of Mtb, causing lethal distortions of the cell wall, while showing no off-target effects in primary human cells or zebrafish embryos. Gran1 is selectively internalized by macrophages, restricting the proliferation of the pathogen, and its hypothesis-driven design serves as a powerful approach for identifying small bioactive compounds with specific antimicrobial activity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Silver Nanoparticles and Their Antibacterial Applications

Tamara Bruna et al.

Summary: Silver nanoparticles have excellent antimicrobial properties against a wide range of bacteria, including drug-resistant strains. Research on the synergistic effects of silver nanoparticles with other antibacterial agents for medical applications is ongoing to effectively treat or prevent infections.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Antimicrobial peptides in domestic animals and their applications in veterinary medicine

C. E. Valdez-Miramontes et al.

Summary: Antimicrobial peptides (AMPs) are molecules with broad-spectrum activity against various pathogens, widely distributed in insects, amphibians, and mammals, playing a key role in the innate immune system. In addition to their antimicrobial and immunomodulatory activity, they have shown regulatory effects on gut microbiota and growth performance.

PEPTIDES (2021)

Review Microbiology

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Zhanyi Yang et al.

Summary: Antimicrobial peptides (AMPs) are considered a viable alternative to antibiotics due to their broad-spectrum antimicrobial activity and ease of synthesis, but they have disadvantages such as low bioavailability, poor protease resistance, and high cytotoxicity. Nanostructured antimicrobial peptides (Ns-AMPs) address these limitations through various nanosystem modifications, improving therapeutic efficacy and reducing side effects. This review highlights the advantages of Ns-AMPs in terms of biological stability and antimicrobial activity, as well as discussing their controlled release mechanisms and future research directions.

FRONTIERS IN MICROBIOLOGY (2021)

Article Immunology

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

Miho Takahashi et al.

Summary: hBD-3 promotes wound healing by enhancing fibroblast proliferation and migration, as well as increasing angiogenesis. It also stimulates the secretion of angiogenic growth factors in fibroblasts through the FGFR1/JAK2/STAT3 pathway activation.

FRONTIERS IN IMMUNOLOGY (2021)

Review Chemistry, Multidisciplinary

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Bee Ha Gan et al.

Summary: Bacterial infections caused by 'superbugs' are on the rise globally, with traditional antibiotics becoming less effective, posing a risk of entering a post-antibiotic era. Antimicrobial peptides (AMPs) have garnered attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. This review discusses various aspects of AMPs, including their physicochemical properties, mechanisms of action, and chemical synthesis strategies for developing novel AMPs.

CHEMICAL SOCIETY REVIEWS (2021)

Article Biochemistry & Molecular Biology

DBAASP v3: database of antimicrobial/cytotoxic activity and structure of peptides as a resource for development of new therapeutics

Malak Pirtskhalava et al.

Summary: DBAASP is a comprehensive database containing information on peptides with antimicrobial properties, continuously updated with tools for developing and optimizing new peptides; while there is an increased interest in antimicrobial peptides, their clinical application is still limited.

NUCLEIC ACIDS RESEARCH (2021)

Review Microbiology

The mycobacterial cell envelope - a moving target

Charles L. Dulberger et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Article Infectious Diseases

A novel in silico antimicrobial peptide DP7 combats MDR Pseudomonas aeruginosa and related biofilm infections

Qi Yin et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Article Biochemistry & Molecular Biology

EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence

William F. Porto et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)

Article Biochemistry & Molecular Biology

Bacterial multi-solute transporters

Dirk J. Slotboom et al.

FEBS LETTERS (2020)

Article Biochemistry & Molecular Biology

Super-Resolution Microscopy Reveals a Direct Interaction of IntracellularMycobacterium tuberculosiswith the Antimicrobial Peptide LL-37

Dhruva Deshpande et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

B1CTcu5: A frog-derived brevinin-1 peptide with anti-tuberculosis activity

Parvin Abraham et al.

PEPTIDES (2020)

Review Microbiology

Resistance Mechanisms to Antimicrobial Peptides in Gram-Positive Bacteria

Lucas Assoni et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Polysaccharide length affects mycobacterial cell shape and antibiotic susceptibility

Alexander M. Justen et al.

SCIENCE ADVANCES (2020)

Review Infectious Diseases

Synergies with and Resistance to Membrane-Active Peptides

Adam Kmeck et al.

ANTIBIOTICS-BASEL (2020)

Article Biotechnology & Applied Microbiology

New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs

Hedmon Okella et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Biotechnology & Applied Microbiology

Nanostructured antimicrobial peptides: The last push towards clinics

Jose Vicente Carratala et al.

BIOTECHNOLOGY ADVANCES (2020)

Review Immunology

Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)

Mohamed Abd El-Gawad El-Sayed Ahmed et al.

EMERGING MICROBES & INFECTIONS (2020)

Article Microbiology

Distributions of Extracellular Peptidases Across Prokaryotic Genomes Reflect Phylogeny and Habitat

Trang T. H. Nguyen et al.

FRONTIERS IN MICROBIOLOGY (2019)

Review Biochemistry & Molecular Biology

Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review

Sara Silva et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2019)

Review Biochemistry & Molecular Biology

A review on anti-tuberculosis peptides: Impact of peptide structure on anti-tuberculosis activity

Sutharsana Yathursan et al.

JOURNAL OF PEPTIDE SCIENCE (2019)

Review Pharmacology & Pharmacy

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

Angela Martin-Serrano et al.

PHARMACEUTICS (2019)

Review Biochemistry & Molecular Biology

Stapled Peptides-A Useful Improvement for Peptide-Based Drugs

Mattia Moiola et al.

MOLECULES (2019)

Review Biochemistry & Molecular Biology

Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives

Rajeshwari Sinha et al.

PROTEIN AND PEPTIDE LETTERS (2019)

Article Microbiology

Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis

Clara Aguilar-Perez et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

Review Microbiology

Cell envelope lipids in the pathophysiology of Mycobacterium tuberculosis

Parul Singh et al.

FUTURE MICROBIOLOGY (2018)

Review Pharmacology & Pharmacy

Antimicrobial peptides as an alternative to anti-tuberculosis drugs

Manaf AlMatar et al.

PHARMACOLOGICAL RESEARCH (2018)

Review Chemistry, Multidisciplinary

Antimicrobial Peptides: Interaction With Model and Biological Membranes and Synergism With Chemical Antibiotics

Axel Hollmann et al.

FRONTIERS IN CHEMISTRY (2018)

Review Medicine, General & Internal

Mycobacterium tuberculosis and lipids: Insights into molecular mechanisms from persistence to virulence

Ciamak Ghazaei

JOURNAL OF RESEARCH IN MEDICAL SCIENCES (2018)

Article Biotechnology & Applied Microbiology

Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis

Akiho Yagi et al.

JOURNAL OF ANTIBIOTICS (2017)

Article Multidisciplinary Sciences

Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane

Laura Chiaradia et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Bacterial aminoacyl phospholipids - Biosynthesis and role in basic cellular processes and pathogenicity

Christoph Slavetinsky et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

Review Immunology

Heterogeneity in tuberculosis

Anthony M. Cadena et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Chemistry, Medicinal

Progress in Self-Assembling Peptide-Based Nanomaterials for Biomedical Applications

Cui-Yun Yu et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Interaction between antimicrobial peptides and mycobacteria

Thomas Gutsmann

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

Review Biotechnology & Applied Microbiology

Antimicrobial peptides as novel anti-tuberculosis therapeutics

Joao P. Silva et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Pharmacology & Pharmacy

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

D. I. Andersson et al.

DRUG RESISTANCE UPDATES (2016)

Article Biochemistry & Molecular Biology

Assembling of the Mycobacterium tuberculosis Cell Wall Core

Anna E. Grzegorzewicz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment

Joao P. Silva et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Review Biochemical Research Methods

The proteome targets of intracellular targeting antimicrobial peptides

Pramod Shah et al.

PROTEOMICS (2016)

Review Genetics & Heredity

The role of epigenetics in tuberculosis infection

Maruthai Kathirvel et al.

EPIGENOMICS (2016)

Review Immunology

Antimicrobial Peptides : An Emerging Category of Therapeutic Agents

Margit Mahlapuu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2016)

Article Microbiology

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47

Neeraj K. Saini et al.

NATURE MICROBIOLOGY (2016)

Article Multidisciplinary Sciences

Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination

Helena Polena et al.

SCIENTIFIC REPORTS (2016)

Article Infectious Diseases

Interaction of antimicrobial peptide with mycolyl transferase in Mycobacterium tuberculosis

Devjani I. Banerjee et al.

INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY (2016)

Review Cell Biology

Anti-Mycobacterial Peptides: From Human to Phage

Tieshan Teng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Article Plant Sciences

Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity

Georgios Daletos et al.

JOURNAL OF NATURAL PRODUCTS (2015)

Article Multidisciplinary Sciences

A new antibiotic kills pathogens without detectable resistance

Losee L. Ling et al.

NATURE (2015)

Article Chemistry, Organic

Evaluation of the antibacterial and antibiofilm activities of novel CRAMP-vancomycin conjugates with diverse linkers

Nigam M. Mishra et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity

Santos Ramirez-Carreto et al.

PEPTIDES (2015)

Article Microbiology

The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

Wei Gao et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Review Biochemistry & Molecular Biology

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

C. J. Cambier et al.

Article Chemistry, Organic

Wollamides: Antimycobacterial Cyclic Hexapeptides from an Australian Soil Streptomyces

Zeinab G. Khalil et al.

ORGANIC LETTERS (2014)

Article Chemistry, Organic

Discovery and Characterization of the Tuberculosis Drug Lead Ecumicin

Wei Gao et al.

ORGANIC LETTERS (2014)

Review Microbiology

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

Abiola O. Olaitan et al.

FRONTIERS IN MICROBIOLOGY (2014)

Review Pharmacology & Pharmacy

Recent developments in protein and peptide parenteral delivery approaches

Ashaben Patel et al.

THERAPEUTIC DELIVERY (2014)

Article Microbiology

Targeting Mycobacterium tuberculosis and Other Microbial Pathogens Using Improved Synthetic Antibacterial Peptides

Santiago Ramon-Garcia et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Article Hematology

Cathelicidin LL-37 Induces Angiogenesis via PGE2-EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin

M. Dolores Salvado et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Peptide Design for Antimicrobial and Immunomodulatory Applications

Evan F. Haney et al.

BIOPOLYMERS (2013)

Article Infectious Diseases

Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis

Bruno Rivas-Santiago et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2013)

Review Biochemistry & Molecular Biology

P4 ATPases: Flippases in Health and Disease

Vincent A. van der Mark et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Biochemistry & Molecular Biology

Structural Basis of Mycobacterial Inhibition by Cyclomarin A

Dileep Vasudevan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Medicine, General & Internal

CURRENT CONCEPTS Tuberculosis

Alimuddin Zumla et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Biochemical Research Methods

Bacterial expression and antibiotic activities of recombinant variants of human β-defensins on pathogenic bacteria and M. tuberculosis

Ligia Corrales-Garcia et al.

PROTEIN EXPRESSION AND PURIFICATION (2013)

Article Chemistry, Medicinal

Synthesis and antimycobacterial activity of calpinactam derivatives

Kenichiro Nagai et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Biochemistry & Molecular Biology

Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis

Ho Jun Lee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Predicting antimicrobial peptides from eukaryotic genomes: In silico strategies to develop antibiotics

Andre C. Amaral et al.

PEPTIDES (2012)

Article Chemistry, Multidisciplinary

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

Esther K. Schmitt et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Microbiology

Molecular Basis for the Selectivity of Antituberculosis Compounds Capreomycin and Viomycin

Rashid Akbergenov et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Microbiology

Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis

Rinki Kapoor et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Pharmacology & Pharmacy

Action-Mechanism of Trichoderin A, an Anti-dormant Mycobacterial Aminolipopeptide from Marine Sponge-Derived Trichoderma sp.

Patamaporn Pruksakorn et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)

Editorial Material Biochemistry & Molecular Biology

Peptoid Origins

Ronald N. Zuckermann

BIOPOLYMERS (2011)

Article Cell Biology

Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages

Avinash Sonawane et al.

CELLULAR MICROBIOLOGY (2011)

Article Immunology

Induction of β-defensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis

C. E. Rivas-Santiago et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2011)

Review Microbiology

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Julian G. Hurdle et al.

NATURE REVIEWS MICROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamic antimicrobial chemotherapy

Kewei Yang et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2011)

Article Biochemistry & Molecular Biology

Anti-Tuberculosis Activity of alpha-Helical Antimicrobial Peptides: De Novo Designed L- and D-Enantiomers Versus L- and D-LL37

Ziqing Jiang et al.

PROTEIN AND PEPTIDE LETTERS (2011)

Article Biochemistry & Molecular Biology

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

William C. Wimley

ACS CHEMICAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa

Sabrin R. M. Ibrahim et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2010)

Article Chemistry, Medicinal

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Review Biochemistry & Molecular Biology

Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes

F. -Xabier Contreras et al.

FEBS LETTERS (2010)

Article Infectious Diseases

Comparison of the activities of the lantibiotics nisin and lacticin 3147 against clinically significant mycobacteria

James Carroll et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2010)

Article Biotechnology & Applied Microbiology

Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905

Nobuhiro Koyama et al.

JOURNAL OF ANTIBIOTICS (2010)

Article Biochemistry & Molecular Biology

cAMP-regulated Protein Lysine Acetylases in Mycobacteria

Subhalaxmi Nambi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome

Robin E. Stanley et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Degradation-resistant protein domains limit host cell processing and immune detection of mycobacteria

Kah Wee Koh et al.

MOLECULAR IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides

Georgiana E. Purdy et al.

MOLECULAR MICROBIOLOGY (2009)

Article Cell Biology

Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

Fatoumata B. Sow et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Infectious Diseases

Antimycobacterial activity of bacteriocins and their complexes with liposomes

Vasily Sosunov et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)

Article Multidisciplinary Sciences

Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

Sylvie Alonso et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Pharmacology & Pharmacy

Human defensins: synthesis and structural properties

Marzena Pazgier et al.

CURRENT PHARMACEUTICAL DESIGN (2007)

Article Multidisciplinary Sciences

Structure of a bacterial multidrug ABC transporter

Roger J. P. Dawson et al.

NATURE (2006)

Article Immunology

β-defensin gene expression during the course of experimental tuberculosis infection

Bruno Rivas-Santiago et al.

JOURNAL OF INFECTIOUS DISEASES (2006)

Review Biochemistry & Molecular Biology

Human beta-defensins

M. Pazgier et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Immunology

Conserved structure and function in the granulysin and NK-lysin peptide family

CMA Linde et al.

INFECTION AND IMMUNITY (2005)

Article Immunology

Role of human neutrophil peptide-1 as a possible adjunct to antituberculosis chemotherapy

A Kalita et al.

JOURNAL OF INFECTIOUS DISEASES (2004)

Review Infectious Diseases

Protein-mediated transbilayer movement of lipids in eukaryotes and prokaryotes: the relevance of ABC transporters

A Tannert et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2003)

Article Biochemical Research Methods

Solution structure of a cathelicidin-derived antimicrobial peptide, CRAMP as determined by NMR spectroscopy

K Yu et al.

JOURNAL OF PEPTIDE RESEARCH (2002)

Review Pharmacology & Pharmacy

Intracellular targets of antibacterial peptides

M Cudic et al.

CURRENT DRUG TARGETS (2002)

Article Immunology

Dermcidin: a novel human antibiotic peptide secreted by sweat glands

B Schittek et al.

NATURE IMMUNOLOGY (2001)