Journal
FRONTIERS IN IMMUNOLOGY
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2023.1034416
Keywords
F-18-FDG PET; CT; NSCLC; PD-1 blockade; hypofractionated radiotherapy; predictive value
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This study investigates the use of F-18-fluorodeoxyglucose (F-18-FDG)-positron emission tomography/computed tomography (PET/CT) as a predictor for lung cancer patients' response to hypofractionated radiotherapy (HFRT) combined with programmed cell death-1 (PD-1) blockade. A retrospective study was conducted on 41 patients with advanced non-small cell lung cancer (NSCLC). PET/CT scans were performed before and after treatment, and treatment responses were evaluated. The study found that new visceral/bone lesions during treatment were related to prognosis and overall survival (OS), and a nomogram was generated to predict patient survival.
PurposeThis retrospective study aimed to investigate F-18-fluorodeoxyglucose (F-18-FDG)-positron emission tomography/computed tomography (PET/CT) as a predictor of response to hypofractionated radiotherapy (HFRT) combined with programmed cell death-1 (PD-1) blockade for lung cancer. MethodsWe included 41 patients with advanced non-small cell lung cancer (NSCLC) in this study. PET/CT was performed before (SCAN-0) and one month (SCAN-1), three months (SCAN-2), and six months (SCAN-3) after treatment. Using the European Organization for Research and Treatment of Cancer 1999 criteria and PET response criteria in solid tumors, treatment responses were classified as complete metabolic response (CMR), partial metabolic response (PMR), stable metabolic disease (SMD), or progressive metabolic disease (PMD). Patients were further categorized as those with metabolic benefits (MB; SMD, PMR, and CMR) and those without MBs (NO-MB; PMD). We analyzed the prognosis and overall survival (OS) of patients with new visceral/bone lesions during treatment. Based on the findings, we generated a nomogram to predict survival. Receiver operating characteristics and calibration curves were used to evaluate the accuracy of the prediction model. ResultsThe mean OS based on SCANs 1, 2, and 3 was significantly higher in patients with MB and those without new visceral/bone lesions. The prediction nomogram for survival had a high area under the curve and a high predictive value based on the receiver operating characteristics and calibration curves. Conclusion(18)FDG-PET/CT has the potential to predict the outcomes of HFRT combined with PD-1 blockade in NSCLC. Therefore, we recommend using a nomogram to predict patient survival.
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