4.8 Article

Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice

Related references

Note: Only part of the references are listed.
Review Rheumatology

The effect of Omega-3 fatty acid supplementation in systemic lupus erythematosus patients: A systematic review

Nina Ramessar et al.

Summary: There is conflicting evidence about the benefits of omega-3 fatty acid supplementation on SLE disease activity, but specific measures have demonstrated benefits.

LUPUS (2022)

Article Biochemistry & Molecular Biology

The omega-3 index is inversely associated with the neutrophil-lymphocyte ratio in adults

Michael I. McBurney et al.

Summary: The neutrophil-lymphocyte ratio (NLR) and the omega-3-index (O3I) are biomarkers related to systemic inflammation and immune system balance. A study found that in a healthy population, a low O3I was associated with an increasing NLR, while a high O3I resulted in a relatively constant (low) NLR.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2022)

Article Immunology

Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation

Lichchavi D. Rajasinghe et al.

Summary: Repeated intranasal instillation of lupus-prone mice with crystalline silica induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, which can be suppressed by dietary supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA). The inflammatory proteins induced by crystalline silica in bronchoalveolar alveolar lavage fluid (BALF) were time-dependently increased, but were attenuated by DHA supplementation. Analysis revealed that the inflammatory proteome in BALF correlated positively with gene expression, ectopic lymphoid tissue neogenesis, and autoantibody induction.

FRONTIERS IN IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators

Zeqi Shi et al.

Summary: Inflammation plays a crucial role in various systemic illnesses, and EETs have been found to have anti-inflammatory effects, reducing inflammation and remodeling of blood vessels. EETs also play important roles in other pathological conditions. Manipulating the AA-CYP450-EETs-sEH pathway has shown potential in alleviating inflammatory diseases, highlighting the importance of this research field.

MOLECULES (2022)

Article Immunology

Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage

Kathryn A. Wierenga et al.

Summary: This study used single-cell RNA sequencing to investigate the mechanism by which omega-3 polyunsaturated fatty acids (PUFAs) affect inflammatory response and interferon-regulated gene expression. The results showed that omega-3 PUFAs can alleviate inflammation and autoimmune diseases by modulating NF-kappa B and IFN1 responses.

FRONTIERS IN IMMUNOLOGY (2022)

Article Food Science & Technology

Fatty Acid and Antioxidant Profile of Eggs from Pasture-Raised Hens Fed a Corn- and Soy-Free Diet and Supplemented with Grass-Fed Beef Suet and Liver

Selin Sergin et al.

Summary: The study demonstrated that using GFB by-products to feed pasture-raised hens in the US can significantly improve the nutrient profile and antioxidant properties of eggs. Eggs from hens supplemented with GFB by-products had higher levels of beneficial fatty acids and reduced agricultural waste.

FOODS (2022)

Review Immunology

The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

Wenlin Qiu et al.

Summary: In this study, the researchers investigated the role of organ-deposited IgG autoantibodies in the development of organ and tissue damage in systemic lupus erythematosus (SLE). They found that IgG plays a crucial role in triggering inflammation and tissue damage, and that the IgG/Fc gamma R signaling pathway is an important therapeutic target in SLE. The study also suggests that TNFR1 inhibitors and Syk inhibitors may be effective in preventing and treating skin and kidney damage in lupus mice.

FRONTIERS IN IMMUNOLOGY (2022)

Review Rheumatology

Update on the diagnosis and management of systemic lupus erythematosus

Antonis Fanouriakis et al.

Summary: Systemic lupus erythematosus (SLE) is characterized by clinical heterogeneity, unpredictable course and flares. Diagnosis remains clinical with limited serologic test confirmation, and newer classification criteria offer more accurate classification. Treatment goals focus on patient survival, flare prevention, organ damage prevention, and quality of life optimization. High-intensity immunosuppressive therapy followed by less intensive therapy is typically used to control disease activity in severe cases of SLE.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Peripheral Vascular Disease

Inhibition of Soluble Epoxide Hydrolase Attenuates Bosutinib-Induced Blood Pressure Elevation

Zhen Cui et al.

Summary: The study found that treatment with bosutinib increases blood pressure and impairs endothelium-dependent vasorelaxation. RNA sequencing revealed that the CYP metabolic pathway mediates the regulation of blood pressure by bosutinib. Bosutinib treatment increased arterial soluble epoxide hydrolase levels and decreased plasma eicosanoid metabolite content in mice.

HYPERTENSION (2021)

Article Biochemistry & Molecular Biology

A Soluble Epoxide Hydrolase Inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, Ameliorates Experimental Autoimmune Encephalomyelitis

Deepa Jonnalagadda et al.

Summary: sEH inhibitor TPPU showed potential in treating MS in animal models by blocking the production of toxic dihydroxy-FAs and increasing certain EpFA species to reduce neuroinflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Resolvin D1 Improves the Treg/Th17 Imbalance in Systemic Lupus Erythematosus Through miR-30e-5p

Tao Cheng et al.

Summary: The study showed that RvD1 levels were significantly lower in active SLE patients compared to inactive individuals and controls, which correlated negatively with SLE disease activity. Treatment with RvD1 improved disease phenotype and inflammation in MRL/lpr mice, as well as rebalanced Treg/Th17 differentiation. Moreover, RvD1 was found to increase Treg and decrease Th17 differentiation in vitro, with miR-30e-5p identified as a key downstream microRNA regulating this process.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus

James J. Pestka et al.

Summary: Dietary intervention with DHA found in fish oil was found to suppress or delay the progression of lupus triggered by environmental toxicant in a mouse model.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Bacterial infections in lupus: Roles in promoting immune activation and in pathogenesis of the disease

Michael Battaglia et al.

Summary: Evidence suggests that lupus patients and lupus-prone mice exhibit significant changes in the bacterial microbiome compared to control subjects, with a potential leaky gut allowing bacterial components to enter circulation and trigger inflammation. Invasive bacterial infections, such as those caused by Staphylococcus aureus and Escherichia coli, are more common and severe in lupus patients, potentially exacerbating autoimmune symptoms through increased immune activation and inflammation.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2021)

Review Nutrition & Dietetics

Lipids in Parenteral Nutrition: Biological Aspects

Philip C. Calder et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2020)

Article Biochemistry & Molecular Biology

Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model

Carlos A. Trindade-da-Silva et al.

FASEB JOURNAL (2020)

Review Rheumatology

Systemic Lupus Erythematosus (SLE) Therapy: The Old and the New

Fabio Basta et al.

RHEUMATOLOGY AND THERAPY (2020)

Article Immunology

Requisite Omega-3 HUFA Biomarker Thresholds for Preventing Murine Lupus Flaring

Kathryn A. Wierenga et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Nutrition & Dietetics

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration

Morteza Sarparast et al.

NUTRIENTS (2020)

Review Biochemistry & Molecular Biology

Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation

Sean D. Kodani et al.

BIOCHIMIE (2019)

Article Urology & Nephrology

Moving Forward With Biologics in Lupus Nephritis

Liliane Hobeika et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2019)

Review Rheumatology

New therapeutic strategies in systemic lupus erythematosus management

Mariele Gatto et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

Review Peripheral Vascular Disease

20-HETE Hypertension and Beyond

Richard J. Roman et al.

HYPERTENSION (2018)

Article Biochemistry & Molecular Biology

Effect of Omega-3 Fatty Acid Supplementation on Oxylipins in a Routine Clinical Setting

Christoph Schmoecker et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Dentistry, Oral Surgery & Medicine

Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption

M. H. Napimoga et al.

JOURNAL OF PERIODONTAL RESEARCH (2018)

Review Biochemistry & Molecular Biology

Mechanisms of Tissue Injury in Lupus Nephritis

Giovanna Flores-Mendoza et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Article Multidisciplinary Sciences

Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

Ranran Tu et al.

SCIENTIFIC REPORTS (2018)

Article Neurosciences

The Effects of sEH Inhibitor on Depression-like Behavior and Neurogenesis in Male Mice

Qiong Wu et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Urology & Nephrology

Redefining lupus nephritis: clinical implications of pathophysiologic subtypes

Feng Yu et al.

NATURE REVIEWS NEPHROLOGY (2017)

Article Multidisciplinary Sciences

Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling

Bing-Qing Deng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

An ω-3-enriched diet alone does not attenuate CCl4-induced hepatic fibrosis

Todd R. Harris et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2016)

Review Rheumatology

New insights into the immunopathogenesis of systemic lupus erythematosus

George C. Tsokos et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Multidisciplinary Sciences

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

Qian Ren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

CYP450-derived oxylipins mediate inflammatory resolution

Derek W. Gilroy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

Melissa A. Bates et al.

PLOS ONE (2016)

Article Pharmacology & Pharmacy

Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers

Sumanta Kumar Goswami et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

Article Biochemistry & Molecular Biology

Soluble Epoxide Hydrolase Inhibitor Attenuates Inflammation and Airway Hyperresponsiveness in Mice

Jun Yang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

Kongyang Ma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Immunology

The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review

Andreas Kronbichler et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

Review Immunology

SLE: Another Autoimmune Disorder influenced by Microbes and Diet?

Qinghui Mu et al.

FRONTIERS IN IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

Cristina Lopez-Vicario et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Pharmacology & Pharmacy

Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice

Ahmed Bettaieb et al.

MOLECULAR PHARMACOLOGY (2015)

Review Cardiac & Cardiovascular Systems

20-HETE and Blood Pressure Regulation Clinical Implications

Cheng-Chia Wu et al.

CARDIOLOGY IN REVIEW (2014)

Review Allergy

TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

Yu Liu et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2014)

Review Biochemistry & Molecular Biology

Expert Panel Workshop Consensus Statement on the Role of the Environment in the Development of Autoimmune Disease

Christine G. Parks et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Chemistry, Physical

Outer Membrane Remodeling: The Structural Dynamics and Electrostatics of Rough Lipopolysaccharide Chemotypes

Roberta P. Dias et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2014)

Article Chemistry, Medicinal

Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

Kin Sing Stephen Lee et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Medicine, Research & Experimental

Concentrated fish oil (Lovaza®) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW)F1 mice

Ganesh V. Halade et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

Suman Kundu et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Multidisciplinary Sciences

Epoxyeicosanoids promote organ and tissue regeneration

Dipak Panigrahy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

Guodong Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Use of a Soluble Epoxide Hydrolase Inhibitor in Smoke-Induced Chronic Obstructive Pulmonary Disease

Lei Wang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

Article Pharmacology & Pharmacy

Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys

A. Ulu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Medicine, Research & Experimental

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

Dipak Panigrahy et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Chemistry, Medicinal

Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

Hong C. Shen et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Review Cardiac & Cardiovascular Systems

Soluble Epoxide Hydrolase Inhibitors and Heart Failure

Hong Qiu et al.

CARDIOVASCULAR THERAPEUTICS (2011)

Article Physiology

Therapeutic potential of DCB-SLE1, an extract of a mixture of Chinese medicinal herbs, for severe lupus nephritis

Pei-Yi Tsai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Review Physiology

Epoxyeicosatrienoic acids and endothelium-dependent responses

William B. Campbell et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)

Article Biochemistry & Molecular Biology

Arachidonic acid cytochrome P450 epoxygenase pathway

Arthur A. Spector

JOURNAL OF LIPID RESEARCH (2009)

Article Biochemistry & Molecular Biology

EET displays anti-inflammatory effects in TNF-α-stimulated human bronchi

Caroline Morin et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

Article Immunology

R-form LPS, the master key to the activation of TLR4/MD-2-positive cells

M Huber et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

KR Schmelzer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Immunology

CD14 is required for MyD88-independent LPS signaling

ZF Jiang et al.

NATURE IMMUNOLOGY (2005)

Article Chemistry, Medicinal

11,12-Epoxyeicosatrienoic acid (11,12-EET):: Structural determinants for inhibition of TNF-α-induced VCAM-1 expression

JR Falck et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)

Review Rheumatology

The pathogenesis of autoimmunity in New Zealand mice

A Borchers et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2000)