Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer

Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve antitumor treatment, due to their ability to regulate the pathways involved in the development of carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro and in vivo studies of these substances in combination with cytotoxic drugs have shown that they reduce resistance and increase therapeutic efficacy. The objective of this review is to summarize the knowledge that is described in the scientific literature on the antitumor and chemo-sensitizing capacity of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpenes. These compounds may hold a promising future in improving the treatment of colorectal cancer.

Automated summary

Colorectal cancer is a major cause of illness and death, and drug resistance is a leading cause of treatment failure. Bioactive compounds derived from vegetables are being studied as a new approach to improve antitumor treatment and reduce drug resistance. In vitro and in vivo studies have shown that these compounds, such as polyphenols, flavonoids, and terpenes, can enhance therapeutic efficacy by reducing resistance. This review summarizes the current knowledge on the antitumor and chemo-sensitizing properties of vegetable-derived biomolecules and their potential in improving colorectal cancer treatment.