Journal
APPLIED SCIENCES-BASEL
Volume 13, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/app13042590
Keywords
microalgae; Cylindrotheca closterium; Pheophorbide a; photodynamic therapy; cancer; biotechnological applications
Ask authors/readers for more resources
The combination of Pheophorbide a and Cylindrotheca closterium displayed significant anti-proliferative activity against melanoma cells under light exposure, suggesting its potential application in photodynamic therapy.
Microalgae, eukaryotic unicellular plants that are distributed worldwide, have been shown to exert anti-proliferative and anticancer activities on various human cancer cell lines. An example of a microalgal bioactive compound is a chlorophyll breakdown product named Pheophorbide a (Ppa), which has been reported to have anti-proliferative properties against various cell lines. This compound has also been tested with light exposure in photodynamic therapy for cancer treatment. In this paper, we screened eleven marine microalgae against a panel of cancer cells, and evaluated the synergistic anti-proliferative effect with Pheophorbide a, with and without photo-activation. The results showed significant anti-proliferative activity against melanoma cells when Ppa was combined with fraction E of the diatom Cylindrotheca closterium plus 1 h photo-activation. Its activity was also analyzed using gene expression and Western blot experiments. Altogether, these data give new insights into the possible application of microalgae for photodynamic therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available