☆ 4.6 Review

Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs

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Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4-Hydroxycholesterolan Interaction Study in Healthy Volunteers

Caroline Gjestad et al.

AAPS JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Functional expression and activity screening of all human cytochrome P450 enzymes in fission yeast

Pradeepraj Durairaj et al.

FEBS LETTERS (2019)

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Review Pharmacology & Pharmacy

Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism

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DRUG METABOLISM REVIEWS (2019)

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Article Biochemical Research Methods

Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood

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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)

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Article Polymer Science

Molecularly imprinted hydrogels for sustained release of sunitinib in breast cancer therapy

Luca Scrivano et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2019)

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Article Oncology

Severe sunitinib-induced myelosuppression in a patient with a CYP 3A4 polymorphism

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JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2018)

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Article Chemistry, Medicinal

Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib

Gracia M. Amaya et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2018)

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Review Pharmacology & Pharmacy

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Palrasu Manikandan et al.

CURRENT DRUG TARGETS (2018)

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Editorial Material Gastroenterology & Hepatology

Update on the Use of Vonoprazan: A Competitive Acid Blocker

David Y. Graham et al.

GASTROENTEROLOGY (2018)

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Article Chemistry, Physical

Electrochemical simultaneous determination of nifedipine and its main metabolite dehydronifedipine using MWCNT modified glassy carbon electrode

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JOURNAL OF MOLECULAR LIQUIDS (2018)

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Article Chemistry, Analytical

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort

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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2018)

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Review Gastroenterology & Hepatology

Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date

Kentaro Sugano

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2018)

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Article Multidisciplinary Sciences

KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

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SCIENTIFIC REPORTS (2018)

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Review Pharmacology & Pharmacy

Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits

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DRUG METABOLISM REVIEWS (2018)

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Review Biochemistry & Molecular Biology

Pharmacogenomics of triazole antifungal agents: implications for safety, tolerability and efficacy

Jarrett R. Amsden et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2017)

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Article Medicine, General & Internal

Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers

Sunny Park et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2017)

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Article Genetics & Heredity

KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

Saskia Koene et al.

ORPHANET JOURNAL OF RARE DISEASES (2017)

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Editorial Material Biotechnology & Applied Microbiology

PharmGKB summary: voriconazole pathway, pharmacokinetics

Julia M. Barbarino et al.

PHARMACOGENETICS AND GENOMICS (2017)

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Article Pharmacology & Pharmacy

The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations

Hirotoshi Echizen

CLINICAL PHARMACOKINETICS (2016)

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Article Chemistry, Medicinal

Quantum Mechanics/Molecular Mechanics Modeling of Drug Metabolism: Mexiletine N-Hydroxylation by Cytochrome P450 1A2

Richard Lonsdale et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2016)

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Article Biochemical Research Methods

A validated simultaneous quantification method for vonoprazan (TAK-438F) and its 4 metabolites in human plasma by the liquid chromatography-tandem mass spectrometry

Tomoki Yoneyama et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2016)

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Review Education, Scientific Disciplines

What is the role of hydroxychloroquine in reducing thrombotic risk in patients with antiphospholipid antibodies?

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HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2016)

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Article Pharmacology & Pharmacy

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism

Timothy S. Tracy et al.

DRUG METABOLISM AND DISPOSITION (2016)

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Article Pharmacology & Pharmacy

The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity

Janne Hukkanen et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

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Article Pharmacology & Pharmacy

Vonoprazan: First Global Approval

Karly P. Garnock-Jones

DRUGS (2015)

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Article Chemistry, Medicinal

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

Slobodan Rendic et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2015)

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Article Pharmacology & Pharmacy

Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase

Shinya Hosaka et al.

DRUG METABOLISM AND DISPOSITION (2015)

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Article Pharmacology & Pharmacy

Metabolic Activation of the Antibacterial Agent Triclocarban by Cytochrome P450 1A1 Yielding Glutathione Adducts

Nils Helge Schebb et al.

DRUG METABOLISM AND DISPOSITION (2014)

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Article Pharmacology & Pharmacy

Simultaneous quantitation of atorvastatin and its two active metabolites in human plasma by liquid chromatography/(-) electrospray tandem mass spectrometry

Pankaj Partani et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2014)

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Review Pharmacology & Pharmacy

Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence

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EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2013)

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Article Biotechnology & Applied Microbiology

PharmGKB summary: tamoxifen pathway, pharmacokinetics

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PHARMACOGENETICS AND GENOMICS (2013)

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Article Pharmacology & Pharmacy

Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions

Yoshiyuki Shirasaka et al.

DRUG METABOLISM AND DISPOSITION (2013)

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Article Chemistry, Medicinal

Synthesis and Toxicopharmacological Evaluation of m-Hydroxymexiletine, the First Metabolite of Mexiletine More Potent Than the Parent Compound on Voltage-Gated Sodium Channels

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JOURNAL OF MEDICINAL CHEMISTRY (2012)

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Article Pharmacology & Pharmacy

Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans

Bill Speed et al.

DRUG METABOLISM AND DISPOSITION (2012)

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Article Pharmacology & Pharmacy

Electrochemistry-Mass Spectrometry Unveils the Formation of Reactive Triclocarban Metabolites

A. Baumann et al.

DRUG METABOLISM AND DISPOSITION (2010)

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Article Pharmacology & Pharmacy

Metabolism of Quetiapine by CYP3A4 and CYP3A5 in Presence or Absence of Cytochrome B5

Gry Vibeke Bakken et al.

DRUG METABOLISM AND DISPOSITION (2009)

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Article Pharmacology & Pharmacy

Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements

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BIOCHEMICAL PHARMACOLOGY (2008)

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Article Psychology, Clinical

Quetiapine and drug interactions: Evidence from a routine therapeutic drug monitoring service

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JOURNAL OF CLINICAL PSYCHIATRY (2007)

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Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus:: Data from LUMINA, a multiethnic US cohort (LUMINA L)

Graciela S. Alarcon et al.

ANNALS OF THE RHEUMATIC DISEASES (2007)

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Article Pharmacology & Pharmacy

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

M. De Bellis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2006)

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Article Pharmacology & Pharmacy

Enantiomer/enantiomer interactions between the S- and R-isomers of omeprazole in human cytochrome P450 enzymes:: Major role of CYP2C19 and CYP3A4

XQ Li et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

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Article Pharmacology & Pharmacy

Grapefruit juice-nifedipine interaction:: possible involvement of several mechanisms

P Odou et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2005)

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Article Pharmacology & Pharmacy

Effect of erythromycin on metabolism of quetiapine in Chinese suffering from schizophrenia

KY Li et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2005)

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Article Chemistry, Medicinal

Stereospecific synthesis of para-hydroxymexiletine and sodium channel blocking activity evaluation

A Catalano et al.

CHIRALITY (2004)

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Review Nutrition & Dietetics

Food-drug interaction: grapefruit juice augments drug bioavailability - mechanism, extent and relevance

A Dahan et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2004)

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Article Pharmacology & Pharmacy

Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice

ML Veronese et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2003)

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Time course of recovery of cytochrome P450 3A function after single doses of grapefruit juice

DJ Greenblatt et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2003)

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Article Pharmacology & Pharmacy

Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole

R Hyland et al.

DRUG METABOLISM AND DISPOSITION (2003)

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Review Immunology

Voriconazole: A new triazole antifungal agent

LB Johnson et al.

CLINICAL INFECTIOUS DISEASES (2003)

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Article Pharmacology & Pharmacy

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

A De Luca et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2003)

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Article Pharmacology & Pharmacy

Esomeprazole: A clinical review

TJ Johnson et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2002)

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Article Chemistry, Medicinal

Effect of oral ketoconazole on first-pass effect of nifedipine after oral administration in dogs

M Kuroha et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2002)

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Article Multidisciplinary Sciences

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

LB Moore et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Medicine, General & Internal

Chiral switches

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