Journal
APPLIED SCIENCES-BASEL
Volume 13, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/app13106045
Keywords
metabolites; hydroxylation; monooxygenases; CYP450; hydroxylated metabolites
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The cytochrome P450 (CYP) enzyme family plays a major role in the metabolism of xenobiotics. Polymorphic and inducible enzymes in this family can alter or enhance drug metabolism and toxicity. Drug-drug interactions can occur due to the inhibition or induction of CYP enzymes. The review aims to summarize significant examples of commonly used drugs and highlight the activity and toxicity of their metabolites.
The cytochrome P450 (CYP) enzyme family is the major enzyme system catalyzing the phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in the environment. A major part of the CYP-dependent xenobiotic metabolism is due to polymorphic and inducible enzymes, which may, quantitatively or qualitatively, alter or enhance drug metabolism and toxicity. Drug-drug interactions are major mechanisms caused by the inhibition and/or induction of CYP enzymes. Particularly, CYP monooxygenases catalyze hydroxylation reactions to form hydroxylated metabolites. The secondary metabolites are sometimes as active as the parent compound, or even more active. The aim of this review is to summarize some of the significative examples of common drugs used for the treatment of diverse diseases and underline the activity and/or toxicity of their metabolites.
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