☆ 4.8 Article

A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes

ADVANCED SCIENCE (2023)

Related references

Note: Only part of the references are listed.

Article Multidisciplinary Sciences

Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

Wenhui Gao et al.

Summary: We report a carbon dot (C-dot) superoxide dismutase (SOD) nanozyme with a catalytic activity comparable to that of natural enzymes. The SOD-like activity of C-dot nanozyme relies on specific chemical modifications and conjugated carbonyl groups for binding and electron transfer. Furthermore, the C-dot SOD nanozymes exhibit intrinsic targeting ability to oxidation-damaged cells and effectively protect neuron cells in the ischemic stroke mouse model.

NATURE COMMUNICATIONS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

Guanning Huang et al.

Summary: This study designed a translational antioxidative agent, HSA-Mn3O4, which effectively inhibits nervous system damage caused by ischemic stroke reperfusion, demonstrating neuroprotective capacity mainly by inhibiting apoptosis and endoplasmic reticulum stress to prevent brain tissue damage.

ACS NANO (2022)

Add to Collection

Article Multidisciplinary Sciences

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Shaofang Zhang et al.

Summary: The authors developed single-atom nanozymes of RhN4, VN4, and Fe-Cu-N-6 with higher catalytic activities than natural enzymes, and demonstrated the recyclability of Rh/VN4 and the scalp healing properties in bioactive sutures.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

Lishuai Feng et al.

Summary: This study introduces a neutrophil-like cell-membrane-coated mesoporous Prussian blue nanozyme, which improves the delivery of the nanozyme to the damaged brain for noninvasive active-targeting therapy in ischemic stroke. The long-term therapeutic efficacy of this nanozyme in ischemic stroke is demonstrated, with a detailed mechanism involving uptake by microglia leading to beneficial effects like microglia polarization, reduced recruitment of neutrophils, decreased neuron apoptosis, and neural cell proliferation. This strategy offers an approach for nanozyme therapy in brain diseases.

ACS NANO (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A Nanozyme-Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke

Juqun Xi et al.

Summary: This study presents a novel strategy to design an artificial peroxisome using a nanozyme with stable and multiple enzymatic activities, which shows promising therapeutic effects for treating hyperuricemia and protecting neurons during ischemic stroke. The nanozyme-based artificial peroxisome is considered a promising candidate for in vivo functions.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection

Article Multidisciplinary Sciences

Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

Haile Liu et al.

Summary: Clusterzymes based on Au-25 clusters exhibit high catalytic activity and selectivity in enzyme-mimicking reactions, such as GPx-like, CAT-like, and SOD-like activities. They can effectively decrease oxidative stress and inflammation in injured brain, showing promise in mitigating neuroinflammation.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Multidisciplinary Sciences

An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury

Xiaoyu Mu et al.

Summary: Artificial enzymes have potential in disease diagnosis and biotechnology due to their high stability, easy synthesis, and cost-effectiveness. The oligomeric nanozyme (O-NZ) showed ultrafast electron transfer and achieved ultrahigh catalytic activity, addressing the limitations of catalytic rate in artificial enzymes.

SCIENCE ADVANCES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Oxygen-Generating Cyanobacteria Powered by Upconversion-Nanoparticles-Converted Near-Infrared Light for Ischemic Stroke Treatment

Jian Wang et al.

Summary: The study introduces a novel approach to stroke treatment by utilizing a nanotechnology-driven biosystem that generates oxygen through photosynthesis, rescuing neurons and treating stroke effectively. This innovative method combines microorganisms and nanotechnology to improve neuronal function recovery in stroke patients, showing promising results in cell-biological, biochemical, and animal-level behavioral data.

NANO LETTERS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Metal-Organic Frameworks for Biomedical Applications

Jie Yang et al.

SMALL (2020)

Add to Collection

Review Pharmacology & Pharmacy

Pathophysiology of Ischemic Stroke: Role of Oxidative Stress

Sofia Orellana-Urzua et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Add to Collection

Article Multidisciplinary Sciences

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Yufeng Liu et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Continuous Electrical Conductivity Variation in M3(Hexaiminotriphenylene)2 (M = Co, Ni, Cu) MOF Alloys

Tianyang Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Oxidase-like MOF-818 Nanozyme with High Specificity for Catalysis of Catechol Oxidation

Minghua Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection

Article Chemistry, Physical

Dopamine sacrificial coating strategy driving formation of highly active surface-exposed Ru sites on Ru/TiO2 catalysts in Fischer-Tropsch synthesis

Shuaishuai Lyu et al.

APPLIED CATALYSIS B-ENVIRONMENTAL (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

Kai Zhang et al.

NANO LETTERS (2019)

Add to Collection

Article Multidisciplinary Sciences

eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics

Xiaoyu Wang et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Multidisciplinary Sciences

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A. Patsopoulos et al.

SCIENCE (2019)

Add to Collection

Review Chemistry, Multidisciplinary

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Jiangjiexing Wu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Add to Collection

Article Chemistry, Physical

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

Lina R. Nih et al.

NATURE MATERIALS (2018)

Add to Collection

Article Cell Biology

PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway

Zhong Lei et al.

CELL DEATH & DISEASE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase

Jahaun Azadmanesh et al.

JOURNAL OF STRUCTURAL BIOLOGY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke

Yanlan Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Clinical Neurology

Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Valery L. Feigin et al.

LANCET NEUROLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Add to Collection

Article Medicine, Research & Experimental

Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles

Chun Zhang et al.

THERANOSTICS (2017)

Add to Collection

Article Cardiac & Cardiovascular Systems

Acute Ischemic Stroke Therapy Overview

Luciana Catanese et al.

CIRCULATION RESEARCH (2017)

Add to Collection

Article Neurosciences

Evolution of Intra-arterial Therapy for Acute Ischemic Stroke in The Netherlands: MR CLEAN Pretrial Experience

Anouk D. Rozeman et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2016)

Add to Collection

Article Medicine, General & Internal

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

Mayank Goyal et al.

LANCET (2016)

Add to Collection

Article Clinical Neurology

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and infl ammation

Angel Chamorro et al.

LANCET NEUROLOGY (2016)

Add to Collection

Article Neurosciences

Evolution of Intra-arterial Therapy for Acute Ischemic Stroke in The Netherlands: MR CLEAN Pretrial Experience

Anouk D. Rozeman et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2016)

Add to Collection

Review Oncology

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

S. J. Thomas et al.

BRITISH JOURNAL OF CANCER (2015)

Add to Collection

Article Chemistry, Multidisciplinary

SOD1 nanozyme salvages ischemic brain by locally protecting cerebral vasculature

Yuhang Jiang et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Multidisciplinary Sciences

Optogenetic neuronal stimulation promotes functional recovery after stroke

Michelle Y. Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

Silvia Manzanero et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

Add to Collection

Article Chemistry, Multidisciplinary

Ceria Nanoparticles that can Protect against Ischemic Stroke

Chi Kyung Kim et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Add to Collection

Article Clinical Neurology

Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice

Hiroyuki Sakata et al.

BRAIN (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury

Devika S. Manickam et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection

Review Biochemistry & Molecular Biology

STAT3 SIGNALING: Anticancer Strategies and Challenges

Paul A. Johnston et al.

MOLECULAR INTERVENTIONS (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Chemistry and biology of reactive oxygen species in signaling or stress responses

Bryan C. Dickinson et al.

NATURE CHEMICAL BIOLOGY (2011)

Add to Collection

Review Cell Biology

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

Rong Jin et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2010)

Add to Collection

Article Biochemical Research Methods

A rotarod test for evaluation of motor skill learning

Hiromi Shiotsuki et al.

JOURNAL OF NEUROSCIENCE METHODS (2010)

Add to Collection

Article Multidisciplinary Sciences

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

Andrew N. Clarkson et al.

NATURE (2010)

Add to Collection

Article Medicine, General & Internal

NXY-059 for the treatment of acute ischemic stroke

Ashfaq Shuaib et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Add to Collection

Article Endocrinology & Metabolism

Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice

JL Chen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2005)

Add to Collection

Article Biochemical Research Methods

Two effective behavioral tasks for evaluating sensorimotor dysfunction following traumatic brain injury in mice

YK Baskin et al.

JOURNAL OF NEUROSCIENCE METHODS (2003)

Add to Collection

Article Chemistry, Multidisciplinary

Predicting the activity of phenolic antioxidants: Theoretical method, analysis of substituent effects, and application to major families of antioxidants

JS Wright et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.