Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion

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Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis

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Summary: YY2 induces tumor cell ferroptosis and suppresses tumorigenesis by inhibiting SLC7A11 transcription, leading to decreased glutathione biosynthesis. YY2 and YY1 competitively bind to the same DNA binding site in the SLC7A11 promoter and antagonistically regulate tumor cell ferroptosis, providing a mechanistic explanation for their opposite regulation on tumorigenesis.

ADVANCED SCIENCE (2022)

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Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

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Lourdes Sainero-Alcolado et al.

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Hepatobiliary & Pancreatic Diseases International (2022)

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NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells

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CELLS (2022)

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Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

Fan Yang et al.

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CELL METABOLISM (2022)

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Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

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YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Ruize Gao et al.

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EMBO MOLECULAR MEDICINE (2021)

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Hyuna Sung et al.

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USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1

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Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease

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Mitochondrial regulation of ferroptosis

Boyi Gan

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion

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