A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect

The local application of drug-loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self-assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone-related peptide-1 (PTHrP-1) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and repair of OP bone defects in small animals are conducted, and the potential of natural bioactive porous scaffold materials to promote the repair of OP bone defects is initially verified. The preparation of safe and economical anti-OP bone repair material provides a theoretical basis for clinical translational applications.

Automated summary

The local application of drug-loaded bioactive scaffold materials shows potential for solving OP bone defects. This study successfully loaded polydopamine nanoparticles and PTHrP-1 onto natural 3D bioactive scaffolds. The scaffolds were found to affect ossification, osteoclastogenesis, and macrophage polarization, and were able to regulate osteoclastic activity and new bone formation in vitro. Furthermore, the potential of these scaffolds to promote the repair of OP bone defects was verified in small animal studies. The preparation of safe and economical anti-OP bone repair material provides a theoretical basis for clinical translational applications.