4.3 Review

An update on pathogenesis and clinical scenario for Parkinson's disease: diagnosis and treatment

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VIRUSES-BASEL (2021)

Review Geriatrics & Gerontology

Alpha-Synuclein as a Biomarker of Parkinson's Disease: Good, but Not Good Enough

Upasana Ganguly et al.

Summary: Parkinson's disease is the second most common neurodegenerative disorder in the elderly, primarily characterized by motor impairment. The lack of a definitive biomarker for PD has led researchers to focus on the potential role of alpha-synuclein as a key protein in the pathogenesis of the disease. Studies have shown promise in measuring different forms of alpha-synuclein in body fluids and peripheral tissues as a potential biomarker for PD, although methodological issues still need to be addressed through further research.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Review Physics, Applied

Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges

Aref Asghari et al.

Summary: The sudden rise of the worldwide SARS-CoV-2 pandemic in early 2020 has required drastic action measures for instant detection and reducing transmission rates. Optical biosensors are crucial for providing a noninvasive, extremely sensitive rapid detection platform during the pandemic.

APPLIED PHYSICS REVIEWS (2021)

Review Genetics & Heredity

The Genetics of Parkinson's Disease and Implications for Clinical Practice

Jacob Oliver Day et al.

Summary: The genetic landscape of Parkinson's disease includes rare high penetrance pathogenic variants, genetic risk factor variants, and high frequency, low penetrance variants which contribute to the risk of developing the disease. Understanding these influences can have a major impact on the clinical care of PD patients.

GENES (2021)

Review Nanoscience & Nanotechnology

A Review on Biosensors and Nanosensors Application in Agroecosystems

Pankaj Sharma et al.

Summary: The past decades have seen a rise in challenges for ensuring global food security, with toxic elements in agricultural products causing various health issues and leading to reported 220,000 deaths annually. Monitoring agricultural ecosystems has traditionally relied on costly and complex techniques, but the growth of nanotechnology has facilitated the development of more affordable and efficient bio and nanosensors for detecting contaminants.

NANOSCALE RESEARCH LETTERS (2021)

Article Neurosciences

Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease

Jamileh Ghalami et al.

Summary: Paeonol demonstrates neuroprotective potential in a rat model of Parkinson's Disease induced by 6-hydroxydopamine, exerting its effects through alleviating oxidative stress, apoptosis, and astrogliosis.

BASIC AND CLINICAL NEUROSCIENCE (2021)

Review Cell Biology

Promising drug targets and associated therapeutic interventions in Parkinson's disease

Sachchida Nand Rai et al.

Summary: Parkinson's disease is a debilitating brain disease with limited treatment options, highlighting the need for novel drug targets to improve patient health. Natural products may play a critical role in controlling the progression of Parkinson's disease.

NEURAL REGENERATION RESEARCH (2021)

Article Clinical Neurology

Health-Related Quality of Life for Parkinson's Disease Patients and Their Caregivers

Michal Lubomski et al.

Summary: The study found that Parkinson's disease patients reported significantly decreased health-related quality of life (HRQoL), with factors such as unemployment, the need for social support services, REM sleep behavior disorder, impulse control disorders, and features suggestive of increasing disease severity contributing to lower HRQoL. Additionally, decreased physical activity, chronic pain, depression, constipation, and upper gastrointestinal dysfunction were associated with reduced HRQoL in PD patients.

JOURNAL OF MOVEMENT DISORDERS (2021)

Review Clinical Neurology

Gait and postural disorders in parkinsonism: a clinical approach

Cecilia Raccagni et al.

JOURNAL OF NEUROLOGY (2020)

Review Genetics & Heredity

Open questions on the nature of Parkinson's disease: from triggers to spreading pathology

Lei Mou et al.

JOURNAL OF MEDICAL GENETICS (2020)

Review Clinical Neurology

Functional Motor Symptoms in Parkinson's Disease and Functional Parkinsonism: A Systematic Review

Marine Ambar Akkaoui et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2020)

Review Medicine, General & Internal

Diagnosis and Treatment of Parkinson Disease A Review

Melissa J. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Biochemistry & Molecular Biology

Advancement in the modelling and therapeutics of Parkinson's disease

Sachchida Nand Rai et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2020)

Article Multidisciplinary Sciences

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Anne-Laure Mahul-Mellier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Nanoscience & Nanotechnology

Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

Jie Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Pharmacology & Pharmacy

Modeling Parkinson's Disease With the Alpha-Synuclein Protein

Monica Gomez-Benito et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Chemistry, Multidisciplinary

α-Synuclein Oligomer Detection with Aptamer Switch on Reduced Graphene Oxide Electrode

Seung Joo Jang et al.

NANOMATERIALS (2020)

Review Biochemistry & Molecular Biology

Therapeutic Nanoparticles and Their Targeted Delivery Applications

Abuzer Alp Yetisgin et al.

MOLECULES (2020)

Review Neurosciences

Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

Saba Naqvi et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

The Role of Oxidative Stress in Parkinson's Disease

Kuo-Hsuan Chang et al.

ANTIOXIDANTS (2020)

Review Neurosciences

Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells

Jenne Tran et al.

NPJ PARKINSONS DISEASE (2020)

Article Clinical Neurology

Parkinson's disease: etiopathogenesis and treatment

Joseph Jankovic et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Review Clinical Neurology

Medical Management and Prevention of Motor Complications in Parkinson's Disease

Stephen D. Aradi et al.

NEUROTHERAPEUTICS (2020)

Review Chemistry, Analytical

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Veronika Gajdosova et al.

SENSORS (2020)

Article Multidisciplinary Sciences

Unobtrusive detection of Parkinson's disease from multi-modal and in-the-wild sensor data using deep learning techniques

Alexandros Papadopoulos et al.

SCIENTIFIC REPORTS (2020)

Proceedings Paper Green & Sustainable Science & Technology

Nanobiosensors: applications in biomedical technology

A. T. Banigo et al.

NANOTECHNOLOGY APPLICATIONS IN AFRICA: OPPORTUNITIES AND CONSTRAINTS (2020)

Review Biotechnology & Applied Microbiology

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective

Sachchida Nand Rai et al.

3 BIOTECH (2020)

Article Neurosciences

Dementia in long-term Parkinson's disease patients: a multicentre retrospective study

Jennifer Y. Y. Szeto et al.

NPJ PARKINSONS DISEASE (2020)

Review Engineering, Biomedical

Brain Delivery of Nanomedicines: Trojan Horse Liposomes for Plasmid DNA Gene Therapy of the Brain

William M. Pardridge

FRONTIERS IN MEDICAL TECHNOLOGY (2020)

Review Chemistry, Multidisciplinary

Nanoparticles: Properties, applications and toxicities

Ibrahim Khan et al.

ARABIAN JOURNAL OF CHEMISTRY (2019)

Review Clinical Neurology

Deep brain stimulation: current challenges and future directions

Andres M. Lozano et al.

NATURE REVIEWS NEUROLOGY (2019)

Review Clinical Neurology

Parkinson's Disease and the Environment

Nicole Ball et al.

FRONTIERS IN NEUROLOGY (2019)

Article Neurosciences

Anti-inflammatory Activity of Ursolic Acid in MPTP-Induced Parkinsonian Mouse Model

Sachchida Nand Rai et al.

NEUROTOXICITY RESEARCH (2019)

Review Neurosciences

The neuropathological diagnosis of Alzheimer's disease

Michael A. DeTure et al.

MOLECULAR NEURODEGENERATION (2019)

Review Biochemistry & Molecular Biology

Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration

Janusz Blasiak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Neurosciences

Dementia with Lewy bodies: an update and outlook

Tiago Fleming Outeiro et al.

MOLECULAR NEURODEGENERATION (2019)

Review Neurosciences

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

Victor M. Pulgar

FRONTIERS IN NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

Timo Strohaeker et al.

NATURE COMMUNICATIONS (2019)

Review Clinical Neurology

An update on best practice of deep brain stimulation in Parkinson's disease

Christian J. Hartmann et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2019)

Review Chemistry, Analytical

The Role of Electrochemical Immunosensors in Clinical Analysis

Fariba Mollarasouli et al.

BIOSENSORS-BASEL (2019)

Review Biochemistry & Molecular Biology

Impact of gene mutation in the development of Parkinson's disease

Suganya Selvaraj et al.

GENES & DISEASES (2019)

Article Biotechnology & Applied Microbiology

A highly sensitive miR-195 nanobiosensor for early detection of Parkinson's disease

Zahra Aghili et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Meeting Abstract Biophysics

High Resolution Structure Determination of Amyloid Fibrils

Robert G. Griffin

BIOPHYSICAL JOURNAL (2018)

Article Multidisciplinary Sciences

Parkinson disease with constipation: clinical features and relevant factors

Qiu-Jin Yu et al.

SCIENTIFIC REPORTS (2018)

Article Pharmacology & Pharmacy

Effect of Chlorogenic Acid Supplementation in MPTP-Intoxicated Mouse

Saumitra S. Singh et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Anesthesiology

Anaesthesiologist's Approach to Awake Craniotomy

Onur Ozlu

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION (2018)

Review Biochemistry & Molecular Biology

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

Justine M. Abais et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Review Clinical Neurology

Nonmotor Symptoms in Parkinson's Disease in 2012: Relevant Clinical Aspects

Anne Marie Bonnet et al.

PARKINSONS DISEASE (2012)