4.6 Article

Implications of altered sirtuins in metabolic regulation and oral cancer

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Sirtuin function and metabolism: Role in pancreas, liver, and adipose tissue and their crosstalk impacting bone homeostasis

Viktorija Avilkina et al.

Summary: Mammalian sirtuins are crucial enzymes that regulate various biological processes and are well characterized in metabolic tissues. Their role in bone activity is important for maintaining bone homeostasis. Understanding the crosstalk between sirtuins, metabolic organs, and bone may contribute to the development of therapeutic strategies for metabolic diseases and osteoporosis.
Review Dentistry, Oral Surgery & Medicine

The ambiguous role of sirtuins in head and neck squamous cell carcinoma

Devaraj Ezhilarasan et al.

Summary: Sirtuins, particularly SIRT1, SIRT2, and SIRT3, play various roles in oral cancer. SIRT1 is reported to act as a tumor suppressor, while SIRT2's role remains unclear in oral cancer. SIRT3 expression is positively correlated with oral malignancies.

ORAL DISEASES (2022)

Article Oncology

The Expression of SIRT6 Is Associated With Treatment Outcome in Elder Patients With Oral Cancer

Haruka Yoshii et al.

Summary: SIRT6 is overexpressed in oral squamous cell carcinoma (OSCC) and is associated with shorter overall survival. It may serve as a potential therapeutic target and prognostic marker in OSCC.

ANTICANCER RESEARCH (2022)

Review Medicine, Research & Experimental

Epithelial-mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Zhao Huang et al.

Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in tumor progression, where epithelial cells lose their junctions and polarity while acquiring mesenchymal properties and invasive ability. EMT is driven by key transcription factors and regulated by multiple signaling pathways. EMT confers cancer cells with metastatic potential and drug resistance, leading to tumor recurrence. Targeting EMT could be a therapeutic option in cancer treatment.

MEDCOMM (2022)

Review Biochemistry & Molecular Biology

Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators

Ewa Maria Kratz et al.

Summary: Sirtuins (SIRTs), enzymes from the family of NAD(+)-dependent histone deacetylases, play crucial roles at the cellular level and are involved in various biochemical processes. Research on SIRTs modulators aims to understand their impact on the organism, potentially leading to positive outcomes in treating certain diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway

Bin Jia et al.

Summary: This study identified miR-770 as an upstream regulator of Sirt7 in metastatic OSCC, with higher miR-770 expression correlating with more prominent OSCC metastasis. The results revealed a new role of Sirt7 downregulation in metastatic OSCC and suggested that miR-770 is a potential target in counteracting OSCC metastasis.

IUBMB LIFE (2021)

Article Gastroenterology & Hepatology

Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α

Huihui Ren et al.

Summary: The study showed that SIRT2 is significantly down-regulated in patients with NAFLD and HFD-induced NAFLD mice, restoring its expression in the liver can alleviate insulin resistance, hepatic steatosis, and systemic inflammation. Targeting the SIRT2-HNF4 alpha pathway may be a promising strategy for NAFLD treatment.

HEPATOLOGY (2021)

Article Cell Biology

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways

Ruoyun Wu et al.

Summary: This study demonstrated that total sesquiterpene glycosides (TSGs) from loquat leaves improved metabolic parameters and prevented liver injury in insulin-resistant (IR) mice induced by high-fat diet. TSG supplementation also alleviated inflammatory response and oxidative stress in IR mice, and modulated signaling pathways related to glucose and lipid metabolism in the liver.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Multidisciplinary Sciences

Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis

Luca Perico et al.

Summary: The study reveals a novel role for the NAD(+)-dependent deacylase SIRT3 in kidney development, controlling early renal development through the regulation of epigenetics and metabolic processes. Deficiency of SIRT3 leads to decreased nephron progenitors, impaired nephrogenesis, and a reduced number of nephrons in the developing kidney.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity

Weili Li et al.

Summary: The study demonstrated that Ferruginol (FGL) exerts cardioprotective effects by enhancing mitochondrial biogenesis and fatty acid oxidation through stimulating the SIRT1-PGC-1 alpha axis.

FRONTIERS IN PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Insulin-Responsive Transcription Factors

Gerald Thiel et al.

Summary: Insulin functions by binding and activating the insulin receptor, which triggers signaling pathways involving various enzymes. These pathways ultimately affect gene transcription, regulating metabolic processes such as glycolysis and lipogenesis. The activation of insulin-responsive transcription factors plays a crucial role in coordinating a wide range of insulin-induced changes in tissues.

BIOMOLECULES (2021)

Article Endocrinology & Metabolism

SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2

Fatema Akter et al.

Summary: SIRT7 interacts with and deacetylates PPAR gamma 2 at the K382 residue, leading to decreased lipid accumulation and dysregulation of lipogenesis-related genes. The findings suggest that SIRT7-dependent deacetylation of PPAR gamma 2 at K382 controls lipogenesis in adipocytes.

JOURNAL OF DIABETES INVESTIGATION (2021)

Article Cell Biology

SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis

Miguel Portillo et al.

Summary: Tau protein hyper-acetylation at residue 174 increases its nuclear presence and is related to DNA damage signaling or lack of SIRT6, both causative of neurodegeneration. This leads to global changes in gene expression, affecting protein synthesis and energy production. AD patients show increased levels of nuclear Tau-K174ac, potentially due to DNA damage signaling and SIRT6 depletion.

CELL REPORTS (2021)

Article Cell Biology

SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes

Francesca Molinari et al.

Summary: The inhibition of SIRT5 stimulates brown adipogenesis in vitro, promoting the expression of brown adipocyte and mitochondrial markers and increasing lipolysis. This approach shows potential as a strategy to target obesity and type 2 diabetes by activating brown adipose tissue.

CELLS (2021)

Article Biochemistry & Molecular Biology

Hypoxic exosomal HIF-1α-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis

Zhu Zeng et al.

Summary: Research shows that hypoxic exosomal circZNF91 can enhance chemoresistance in pancreatic cancer cells through the miR-23b-3p/SIRT1/HIF-1α pathway. Clinical data also indicates that upregulated circZNF91 is associated with overexpression of glycolytic enzymes and shorter overall survival time in PC patients.

ONCOGENE (2021)

Article Cell Biology

SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

Danish Khan et al.

Summary: Pathological lipid accumulation in cardiomyocytes is associated with enhanced fatty acid uptake through specific transporters, regulated by the transcription factor SIRT6. SIRT6 deficiency leads to increased expression of fatty acid transporters and lipid accumulation, with its interaction with PPARγ being critical in regulating transporter expression.്

CELL REPORTS (2021)

Article Cell Biology

SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

Elma Zaganjor et al.

Summary: This study provides a temporal analysis of adipocyte differentiation, uncovering early metabolic events that stimulate transcriptional reprogramming.

CELL REPORTS (2021)

Article Medicine, Research & Experimental

SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux

Feiye Zhou et al.

Summary: SIRT2 plays a crucial role in glucose homeostasis by regulating insulin secretion and glucose tolerance; its deficiency inhibits GSIS by affecting the degradation of GKRP and ALDOA proteins; SIRT2 overexpression enhances insulin secretion through deacetylation of GKRP in beta-cells and promoting its degradation.

THERANOSTICS (2021)

Article Biochemistry & Molecular Biology

SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity

Tian Zhang et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Biochemistry & Molecular Biology

SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKα signaling pathway

Jieyun Hong et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Article Cell Biology

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Tian Hu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Cell Biology

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

Brian C. Gilmour et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

Article Cell Biology

Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice

Ming Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

Roles of Mitochondrial Sirtuins in Mitochondrial Function, Redox Homeostasis, Insulin Resistance and Type 2 Diabetes

Chih-Hao Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Endocrinology & Metabolism

Metabolic landscape of oral squamous cell carcinoma

Jessica Gardone Vitorio et al.

METABOLOMICS (2020)

Review Cell Biology

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Fangzhou Jiao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Article Oncology

The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer

Zhou Yang et al.

FRONTIERS IN ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

A Molecular Perspective on Sirtuin Activity

Carla S. S. Teixeira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

SIRT6 overexpression inhibits cementogenesis by suppressing glucose transporter 1

Liyuan Huang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Endocrinology & Metabolism

Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function

Munehiro Kitade et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

Ming Tang et al.

SCIENCE ADVANCES (2019)

Article Urology & Nephrology

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

Takuto Chiba et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Medicine, Research & Experimental

SIRT6 as a potential target for treating insulin resistance

Wei Tang et al.

LIFE SCIENCES (2019)

Article Medicine, Research & Experimental

Dua PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction

Charikleia Kalliora et al.

JCI INSIGHT (2019)

Article Biochemistry & Molecular Biology

Database resources of the National Center for Biotechnology Information

Richa Agarwala et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

Xiu-Fei Chen et al.

EMBO REPORTS (2018)

Review Endocrinology & Metabolism

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

Nadia Bougarne et al.

ENDOCRINE REVIEWS (2018)

Article Medicine, General & Internal

SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma

Yuan-Yuan Kang et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2018)

Review Virology

Viruses as key modulators of the TGF-β pathway; a double-edged sword involved in cancer

Habibollah Mirzaei et al.

REVIEWS IN MEDICAL VIROLOGY (2018)

Article Cell Biology

Infection Reveals a Modification of SIRT2 Critical for Chromatin Association

Jorge M. Pereira et al.

CELL REPORTS (2018)

Article Medicine, General & Internal

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice

Yipeng Du et al.

EBIOMEDICINE (2018)

Article Multidisciplinary Sciences

Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

Jingyi Liu et al.

NATURE COMMUNICATIONS (2018)

Review Endocrinology & Metabolism

Sirtuins and Insulin Resistance

Shuang Zhou et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Advances in Cellular Characterization of the Sirtuin lsoform, SIRT7

Di Wu et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

Henryk Jesko et al.

NEUROCHEMICAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells

Jeovanis Gil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Endocrinology & Metabolism

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

Mingming Zhang et al.

JOURNAL OF PINEAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription

Maximilian F. Blank et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

Jian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Dentistry, Oral Surgery & Medicine

CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells

Takahisa Murofushi et al.

JOURNAL OF ORAL SCIENCE (2017)

Review Food Science & Technology

The sirtuins: Markers of metabolic health

Jeffrey D. Covington et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

Article Biochemistry & Molecular Biology

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents

Pei-Ying Zhang et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Endocrinology & Metabolism

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

Sakari Jukarainen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Biochemistry & Molecular Biology

The role of sirtuins in cellular homeostasis

Wioleta Kupis et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture

Anu Priyanka et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2016)

Review Dentistry, Oral Surgery & Medicine

Oral submucous fibrosis: review on mechanisms of malignant transformation

Rasika Priyadharshani Ekanayaka et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2016)

Article Biochemistry & Molecular Biology

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

Yuya Nishida et al.

MOLECULAR CELL (2015)

Review Endocrinology & Metabolism

Application of Berberine on Treating Type 2 Diabetes Mellitus

Bing Pang et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2015)

Article Multidisciplinary Sciences

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

Ting Sun et al.

NATURE COMMUNICATIONS (2015)

Review Oncology

The multifaceted functions of sirtuins in cancer

Angeliki Chalkiadaki et al.

NATURE REVIEWS CANCER (2015)

Article Biotechnology & Applied Microbiology

Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma

Georgi Mishev et al.

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2014)

Article Cell Biology

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

Tatsuya Yoshizawa et al.

CELL METABOLISM (2014)

Article Chemistry, Medicinal

Discovery of Novel and Selective SIRT6 Inhibitors

Marco Daniele Parenti et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Biochemical Research Methods

A Proteomic Perspective of Sirtuin 6 (SIRT6) Phosphorylation and Interactions and Their Dependence on Its Catalytic Activity

Yana V. Miteva et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

Article Biochemical Research Methods

Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis

Yuan-Chin Tsai et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

Article Biochemistry & Molecular Biology

Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

I-Chieh Chen et al.

MOLECULAR CANCER (2014)

Review Biochemistry & Molecular Biology

Chromatin and beyond: the multitasking roles for SIRT6

Site Kugel et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Article Evolutionary Biology

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

Susan Costantini et al.

BMC EVOLUTIONARY BIOLOGY (2013)

Article Cell Biology

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

Matthew J. Rardin et al.

CELL METABOLISM (2013)

Article Biochemistry & Molecular Biology

A miR-34a-SIRT6 axis in the squamous cell differentiation network

Karine Lefort et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

Shashi Kiran et al.

FEBS JOURNAL (2013)

Article Biochemistry & Molecular Biology

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

Maimon E. Hubbi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation

Gaelle Laurent et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Role of SIRT3 in the regulation of redox balance during oral carcinogenesis

I-Chieh Chen et al.

MOLECULAR CANCER (2013)

Article Biochemistry & Molecular Biology

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

Gaelle Laurent et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

Jeongsoon Park et al.

MOLECULAR CELL (2013)

Article Dentistry, Oral Surgery & Medicine

SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients

Akira Noguchi et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2013)

Article Biochemistry & Molecular Biology

Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation

William C. Hallows et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Cell Biology

Sirtuins as regulators of metabolism and healthspan

Riekelt H. Houtkooper et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Cell Biology

SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2

Matthew D. Hirschey et al.

AGING-US (2011)

Article Biochemistry & Molecular Biology

Structure and Biochemical Functions of SIRT6

Patricia W. Pan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Camilla Burnett et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Proteomic Analyses of Sirt1-Mediated Cisplatin Resistance in OSCC Cell Line

Ping Xiong et al.

PROTEIN JOURNAL (2011)

Review Pathology

Mammalian Sirtuins: Biological Insights and Disease Relevance

Marcia C. Haigis et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Review Biochemistry & Molecular Biology

Structural basis for sirtuin function: What we know and what we don't

Brandi D. Sanders et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Biochemistry & Molecular Biology

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Lei Zhong et al.

Article Biochemistry & Molecular Biology

NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10

Yongjie Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

Cuiying Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

Ji-Hong Lim et al.

MOLECULAR CELL (2010)

Article Multidisciplinary Sciences

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Matthew D. Hirschey et al.

NATURE (2010)

Review Biochemistry & Molecular Biology

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

Eric Verdin et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Nutrition & Dietetics

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

Asma Ejaz et al.

JOURNAL OF NUTRITION (2009)

Review Oncology

How does SIRT1 affect metabolism, senescence and cancer?

Christopher L. Brooks et al.

NATURE REVIEWS CANCER (2009)

Article Biochemistry & Molecular Biology

Substrates and regulation mechanisms for the human mitochondrial Sirtuins Sirt3 and Sirt5

Christine Schlicker et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

Nagalingam R. Sundaresan et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Eriko Michishita et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

David B. Lombard et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

Nidhi Ahuja et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

Brian J. North et al.

PLOS ONE (2007)

Article Biochemistry & Molecular Biology

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacrtylase SIRT1

Masaya Tanno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

Anja Schuetz et al.

STRUCTURE (2007)

Review Biochemistry & Molecular Biology

SIR2: a potential target for calorie restriction mimetics

Danica Chen et al.

TRENDS IN MOLECULAR MEDICINE (2007)

Article Biochemistry & Molecular Biology

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells

L Bordone et al.

PLOS BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

R Mostoslavsky et al.

Article Multidisciplinary Sciences

HST2 mediates SIR2-independent life-span extension by catorie restriction

DW Lamming et al.

SCIENCE (2005)

Article Biochemical Research Methods

Protein homology detection by HMM-HMM comparison

J Söding

BIOINFORMATICS (2005)

Article Multidisciplinary Sciences

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

JT Rodgers et al.

NATURE (2005)

Article Genetics & Heredity

Complete sequencing and characterization of 21,243 full-length human cDNAs

T Ota et al.

NATURE GENETICS (2004)

Article Multidisciplinary Sciences

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

F Picard et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

BJ North et al.

MOLECULAR CELL (2003)

Article Multidisciplinary Sciences

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

P Onyango et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Chemistry of gene silencing:: The mechanism of NAD+-dependent deacetylation reactions

AA Sauve et al.

BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Structure of the histone deacetylase SIRT2

MS Finnin et al.

NATURE STRUCTURAL BIOLOGY (2001)