Journal
NANOMATERIALS
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nano13061102
Keywords
layered double hydroxide; inorganic nano vehicle; drug delivery; bio-imaging; therapy; diagnosis; theranostics
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Two-dimensional nanomaterials, especially layered double hydroxides (LDHs), have found extensive applications in biomedical field due to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. This review summarizes the synthetic strategies and therapeutic actions of single-function LDH-based nanohybrids, as well as the recently developed multifunctional systems for drug delivery and bio-imaging (from 2019 to 2023).
Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging.
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