4.7 Article

Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents

Journal

NANOMATERIALS
Volume 13, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/nano13071174

Keywords

titanium dioxide nanomaterial; physico-chemical properties; biodistribution; nanotoxicity

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Titanium dioxide nanoparticles (TiO2 NPs) are a major source of human exposure to nanoparticulate matter. Although potential toxic effects have been demonstrated, the correlation between NP properties and their interaction with biological targets is not fully understood. This study prepared engineered TiO2 NPs with different geometries and administered them intravenously in mice. The results showed that the accumulation of TiO2 NPs in organs was low, with a longer-lasting presence in the lungs. Rod-shaped NPs were the most toxic and could induce pulmonary alterations and hepatocellular injury. Small physico-chemical differences dramatically modified accumulation and safety.
Titanium dioxide nanoparticles (TiO2 NPs) are one of the main sources of the nanoparticulate matter exposure to humans. Although several studies have demonstrated their potential toxic effects, the real nature of the correlation between NP properties and their interaction with biological targets is still far from being fully elucidated. Here, engineered TiO2 NPs with various geometries (bipyramids, plates, and rods) have been prepared, characterized and intravenously administered in healthy mice. Parameters such as biodistribution, accumulation, and toxicity have been assessed in the lungs and liver. Our data show that the organ accumulation of TiO2 NPs, measured by ICP-MS, is quite low, and this is only partially and transiently affected by the NP geometries. The long-lasting permanence is exclusively restricted to the lungs. Here, bipyramids and plates show a higher accumulation, and interestingly, rod-shaped NPs are the most toxic, leading to histopathological pulmonary alterations. In addition, they are also able to induce a transient increase in serum markers related to hepatocellular injury. These results indicate that rods, more than bipyramidal and spherical geometries, lead to a stronger and more severe biological effect. Overall, small physico-chemical differences can dramatically modify both accumulation and safety.

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