Recent advances in modified poly (lactic acid) as tissue engineering materials

Review Polymer Science

Polylactic acid (PLA) membrane-significance, synthesis, and applications: a review

Neha More et al.

Summary: This review explores the synthesis routes and applications of polylactic acid (PLA) membranes, as well as their combination with other copolymers. The detailed structure and degradation mechanism of PLA membranes are also discussed.

POLYMER BULLETIN (2023)

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Article Chemistry, Applied

In vitro and in vivo efficacy of poly(lactic acid) nanofiber packaging containing essential oils from Ocimum basilicum L. and Ocimum gratissimum L. against Aspergillus carbonarius and Aspergillus niger in table grapes

Rafaela Magalhaes Brandao et al.

Summary: In this study, a novel active packaging was developed by incorporating poly(lactic acid) nanofibers and essential oils from basil plants. The results showed that this active packaging effectively controlled the invasion of A. carbonarius and A. niger on table grapes and reduced the production of ochratoxin A. Additionally, the packaging preserved the quality and shelf life of the grapes.

FOOD CHEMISTRY (2023)

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Review Automation & Control Systems

3D printing of polylactic acid: recent advances and opportunities

Tomy Muringayil Joseph et al.

Summary: Bio-based polymers are a class of polymers made by living organisms, with only a few known and commercialized so far. They have not been widely applied due to poor mechanical strength and economic constraints, but have become suitable candidates for biological applications. As consumers become more aware of the environmental impact of petrochemical polymers and the global transition away from long-lasting plastics, there is increasing interest in previously unattainable sectors. Bio-based polymers can be direct replacements or completely novel polymers, such as polylactide, with improved technical specifications. Polylactic acid (PLA) has gained recognition as a biodegradable thermoplastic for use in 3D printing, particularly in extrusion-based technologies. This review examines the chemical structure, manufacturing techniques, standard features, and market situation of PLA, focusing on its use in extrusion-based 3D printing with highlighted examples of 3D-printed PLA items.

INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY (2023)

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Article Pharmacology & Pharmacy

Asiaticoside polymeric nanoparticles for effective diabetic wound healing through increased collagen biosynthesis: In-vitro and in-vivo evaluation

Saibhargav Narisepalli et al.

Summary: This study developed a gelatin-based biodegradable hydrogel embedded with Asiaticoside polymeric nanoparticles (AST PNP) to enable sustained release of AST and enhance its therapeutic effects. The AST PNP demonstrated sustained release profile and enhanced intra-cellular uptake in fibroblasts, leading to significant proliferation and migration of fibroblasts and improved collagen biosynthesis. The application of AST PNP gel also showed improved wound healing efficacy in diabetic rats.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Review Polymer Science

Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation

Kapender Phogat et al.

Summary: There has been significant interest in developing injectable hydrogel scaffolds for efficient healing and regeneration of defective bone tissues. These scaffolds can be injected into irregularly shaped defects and act as a reservoir for necessary components for bone tissue repair. The trend is to develop nanocomposite scaffolds that mimic the hierarchical nanostructure and composition of natural bone by combining biopolymers and inorganic nanofillers. The ability to tailor these scaffolds to patient-specific bone properties leads to better biological responses.

JOURNAL OF APPLIED POLYMER SCIENCE (2023)

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Article Materials Science, Multidisciplinary

3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

Maria-Eirini Grigora et al.

Summary: This study investigated the effect of two different types of bioactive coatings on the properties of 3D printed poly(lactic acid)/montmorillonite nanocomposite scaffolds. The scaffolds were coated with ordered mesoporous strontium bioglass (SrBG) and SrBG combined with nanohydroxyapatite (nHA) using a simple dip coating procedure. The coatings improved the hydrophilicity, elastic modulus, and hardness of the scaffolds. Moreover, the coating process enhanced biomineralization and promoted the differentiation of stem cells towards osteoblasts, making it a fast, economical, and effective method for bone tissue engineering applications.

JOURNAL OF MATERIALS SCIENCE (2023)

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Article Materials Science, Multidisciplinary

Magnetic polylactic acid-calcium phosphate-based biocomposite as a potential biomaterial for tissue engineering applications

Tania S. S. Carvalho et al.

Summary: This study aims to enhance the magnetic susceptibility of PLA-based biocomposites by incorporating 5 wt% of iron doped biphasic calcium phosphate (FeBCP) powders into the PLA matrix, avoiding the use of magnetic nanoparticles with unclear long-term side effects. The FeBCP composites showed ferromagnetic-like behavior, superior tensile strength, and cytocompatibility compared to PLA or non-doped composites. This proof of concept opens up possibilities for future development of biomedical applications utilizing magnetic PLA-based biocomposites.

MATERIALS CHEMISTRY AND PHYSICS (2023)

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Article Biochemistry & Molecular Biology

Rosmarinic and Glycyrrhetinic Acid-Modified Layered Double Hydroxides as Functional Additives for Poly(Lactic Acid)/Poly(Butylene Succinate) Blends

Francesca Cicogna et al.

Summary: Immobilizing natural antioxidant and biologically active molecules in layered double hydroxides (LDHs) is an excellent method to retain and release these substances in a controlled manner, as well as protect them from thermal and photochemical degradation.

MOLECULES (2023)

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Article Polymer Science

The highly absorbent polyurethane/polylactic acid blend electrospun tissue scaffold for dermal wound dressing

Sema Samatya Yilmaz et al.

Summary: This study produced novel hollow nanofiber materials through coaxial electrospinning from polyurethane (PU)/poly(lactic acid) (PLA) blend nanofibers of different weight ratios. These materials were developed as tissue scaffolds for dermal wound dressing, with properties such as absorption of exudate liquid, quick drying, high mechanical properties, biocompatibility, and support for fibroblast cell growth. The characteristics of hollow PU/PLA nanofibers were compared to solid PU/PLA nanofibers, with hollow nanofibers being thinner and having a production range of 235-518 nm. The hollow PU/PLA nanofiber with a weight ratio of 20/80 showed the highest fibroblast cell viability.

POLYMER BULLETIN (2023)

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Article Polymer Science

Synthesis and characterization of biphasic layered structure composite with simultaneous electroconductive and piezoelectric behavior as a scaffold for bone tissue engineering

Mina Shabani Samghabadi et al.

Summary: In recent years, materials with piezoelectric and electroconductive behavior have gained interest for bone scaffolds due to their potential in mimicking bone tissues. This study focuses on preparing three-dimensional laminated scaffolds using piezoelectric PVDF/PLA nanofibrous mats embedded into porous oxidized alginate/gelatin/PPy-g-gelatin hydrogel precursor structures, resulting in a fiber-hydrogel scaffold. The prepared scaffold exhibits enhanced mechanical properties, electrical conductivity, and piezoelectricity, making it suitable for bone tissue engineering applications.

POLYMERS FOR ADVANCED TECHNOLOGIES (2023)

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Article Nanoscience & Nanotechnology

Biodegradable and Bioabsorbable Polylactic Acid Ferroelectrets with Prominent Piezoelectric Activity

Xingchen Ma et al.

Summary: This article reports biodegradable and bioabsorbable ferroelectret films made from polylactic acid (PLA) resins for highly sensitive transducer applications. By modification of the microstructure and polarization, pronounced longitudinal and transverse piezoelectric activities are realized in a single material. The preparation procedure of the PLA ferroelectrets is compatible with large-scale production lines and thus can greatly promote their applications in green electronics.

ADVANCED ELECTRONIC MATERIALS (2023)

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Review Engineering, Biomedical

Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Behzad Shiroud Heidari et al.

Summary: Tendon and ligament injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many different types of biopolymers have been studied in TL regeneration, but most have not been used clinically.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Embedding Silk Fibroin-Alginate Hydrogel in a 3D-Printed Porous Poly(Lactic Acid) Bone Tissue Scaffold Augments Stem Cell Function

Monika Rajput et al.

Summary: Porous PLA scaffolds were prepared by fused filament fabrication, and a silk fibroin-alginate (SF/Alg) blend hydrogel loaded with hMSCs was loaded into the scaffold's pores. The gel-loaded PLA scaffolds showed stability, significant enhancement of hMSC proliferation and viability, and higher osteogenic differentiation. This combination offers a promising route for enhancing the bioactivity of 3D-printed PLA scaffolds.

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE (2023)

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Article Chemistry, Applied

Improved thermal insulation and compressive property of bimodal poly (lactic acid)/cellulose nanocomposite foams

Qian Ren et al.

Summary: In this study, an innovative PLA/CNF nanocomposite foam with a bimodal cell structure was prepared using a simple one-step depressurization foaming process with supercritical carbon dioxide as the foaming agent. The cell structure of the foam was influenced by the crystallization rate and phase interface. The prepared foam exhibited high expansion ratio, low thermal conductivity, and excellent compression performance, making it suitable for applications in packaging and construction materials.

CARBOHYDRATE POLYMERS (2023)

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Article Chemistry, Physical

Hydroxyapatite - Al2O3 reinforced poly- (lactic acid) hybrid coatings on magnesium: Characterization, mechanical and in-vitro bioactivity properties

Mehmet Topuz

Summary: In this research, a hydroxyapatite-Al2O3 reinforced poly (lactic acid) hybrid coating was synthesized on magnesium to improve interface strength, corrosion properties, and dissolution rate. The coatings were produced using the spin-coating technique of the synthesized solutions. The characterization, mechanical properties, and in-vitro bioactivity of the hybrid coatings were investigated.

SURFACES AND INTERFACES (2023)

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Article Biophysics

Controlled growth factor delivery via a degradable poly(lactic acid) hydrogel microcarrier synthesized using degassed micromolding lithography

Wookyoung Jang et al.

Summary: Controlled and targeted delivery of growth factors to biological environments is achieved using PLA hydrogel microparticles synthesized via DML, which have superior biocompatibility and biodegradability. The encapsulated cargoes, including a model protein and fibroblast growth factor, are uniformly distributed within the microparticles. The release of encapsulated cargoes is efficiently controlled and extended by adjusting the monomer concentration and adding a hydrolytically stable crosslinker.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Mechanics

4D printing of shape memory polybutylene succinate/polylactic acid (PBS/PLA) and its potential applications

Cheng Lin et al.

Summary: 4D printing, utilizing time as the fourth dimension, has great potential in biomedical applications for developing patient-specific implants. This study focuses on the preparation and characterization of shape memory PBS/PLA composite filament for FDM, along with the photothermal properties of graphene oxide functionalized PBS/PLA under NIR irradiation. The NIR-triggered 4D transformation of porous scaffold shows promising application prospects in tissue engineering and photothermal therapy.

COMPOSITE STRUCTURES (2022)

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Review Polymer Science

Tailoring of advanced poly(lactic acid)-based materials: A review

Stoja Milovanovic et al.

Summary: This review provides an overview of conventional and up-to-date technologies for PLA processing, as well as the influence of processing parameters and polymer characteristics on the properties of the final material. Various possibilities for tailoring properties of PLA-based materials are highlighted, offering rich potential for applications in different industries.

JOURNAL OF APPLIED POLYMER SCIENCE (2022)

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Article Engineering, Biomedical

Poly (ε-caprolactone)/Poly (lactic acid) fibers produced by rotary jet spinning for skin dressing with antimicrobial activity

Juliana C. Rosa et al.

Summary: The rotary jet spinning technique allows for the production of biomaterials that can be used in diagnostic or surgical applications involving biological systems. These materials can be composed of synthetic or natural compounds and can incorporate drugs for therapeutic purposes. The study found that rotary jet spinning can produce satisfactory amounts of drug-loaded fibers for wound repair.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Article Biochemistry & Molecular Biology

High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis

Kunio Nakata et al.

Summary: The three-dimensional structure of phosphoketolase (PKT) from Bifidobacterium longum was determined using cryo-EM single-particle analysis. The study observed interesting structural features and multiple conformations of amino acid residues, as well as the presence of water molecules. The conformational changes of the QN-loop were found to be related to the enzymatic function of PKT.

JOURNAL OF STRUCTURAL BIOLOGY (2022)

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Article Polymer Science

Natural Fiber-Reinforced Polylactic Acid, Polylactic Acid Blends and Their Composites for Advanced Applications

R. A. Ilyas et al.

Summary: This article presents the research progress and characteristics of polyactic acid (PLA) and its natural fiber-based green composites. PLA, as a thermoplastic polymer, has wide potential in replacing traditional polymers. Green composites, with advantages such as degradability, recyclability, high strength, and low toxicity, have been extensively used in fields like packaging and medicine. The article also discusses the research issues, challenges, and future development directions of PLA-based green composites.

POLYMERS (2022)

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Review Pharmacology & Pharmacy

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

Antonios Vlachopoulos et al.

Summary: The sustained release of pharmaceutical substances through polymeric microparticles is a convenient and widely-used drug delivery system. Poly(lactic acid) and poly(lactic-co-glycolic acid) microparticles are frequently used biodegradable carriers for drug encapsulation.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

How far is Lignin from being a biomedical material?

Sigit Sugiarto et al.

Summary: The review highlights the potential of utilizing lignin as a versatile biomaterial and discusses the challenges and outlook in developing and enhancing biomaterials through chemical modifications of lignin.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Poly(lactic acid)-Based Electrospun Fibrous Structures for Biomedical Applications

Homa Maleki et al.

Summary: Poly(lactic acid) (PLA) is a biodegradable material with favorable characteristics, making it a promising biopolymer for biomedical applications. Electrospun PLA nanofibers, with features such as similarity to the extracellular matrix, large specific surface area, and tunable mechanical properties, have shown great potential in the medical field.

APPLIED SCIENCES-BASEL (2022)

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Review Chemistry, Multidisciplinary

Fermentative Lactic Acid Production From Lignocellulosic Feedstocks: From Source to Purified Product

Dragomir Yankov

Summary: This review summarizes the research and progress in lactic acid production from inexpensive and renewable resources over the past 5 years, covering topics such as raw materials, pretreatment and detoxification methods, lactic acid-producers, separation techniques, process organization approaches, and optimization challenges and solutions.

FRONTIERS IN CHEMISTRY (2022)

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Article Materials Science, Multidisciplinary

Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications

Karla A. Barbosa et al.

Summary: Polymeric membranes are a promising alternative to conventional dressings for wound-healing applications. This study successfully produced and characterized poly(L-lactic acid) membranes incorporated with curcumin particles using rotary jet spinning technique. The membranes demonstrated thermal stability, adequate mechanical strength, low degradation rates, and sustained release of curcumin.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2022)

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Review Biochemistry & Molecular Biology

Lignin-Based Porous Biomaterials for Medical and Pharmaceutical Applications

Nan Nan et al.

Summary: Lignin-based porous biomaterials have strong potential applications in medicine, such as drug delivery, tissue engineering, and wound dressing. The addition of lignin can modify the materials' properties, while the size, shape, and distribution of pores determine the materials' porous structure and adsorption ability.

BIOMEDICINES (2022)

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Review Biochemistry & Molecular Biology

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

Ioannis Gardikiotis et al.

Summary: Wound dressing design is a rapidly growing field in the medical wound-care market worldwide. It uses biopolymers and other materials to manage wounds by targeting the four phases of healing. However, there are still issues with current biopolymer materials, and combining them with molecular biology approaches represents the future of wound healing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Engineering, Biomedical

Fabrication of 3D Printed poly(lactic acid) strut and wet-electrospun cellulose nano fiber reinforced chitosan-collagen hydrogel composite scaffolds for meniscus tissue engineering

Oylum Colpankan Gunes et al.

Summary: The study aimed to develop chitosan-collagen hydrogel composite scaffolds for meniscus cartilage tissue engineering. By incorporating poly(lactic acid) struts and nanofibrous cellulose into the matrix, the scaffold exhibited favorable cellular activities and mechanical properties. All the hydrogel composite scaffolds had interconnected microporous structures and similar swelling ratios and water content values to native cartilage extracellular matrix. The compressive strength of the scaffolds was suitable for cartilage tissue engineering applications. The scaffold containing 0.3% genipin showed the highest tan delta value at a frequency of 1Hz. In vitro analysis demonstrated that this scaffold had no cytotoxic effects and facilitated cell attachment, proliferation, and migration.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Review Pharmacology & Pharmacy

Rotary Jet Spinning (RJS): A Key Process to Produce Biopolymeric Wound Dressings

Juliana O. Bahu et al.

Summary: This review discusses the use of rotating jet spinning (RJS) technique to produce polymeric fibers for wound dressings. These fibers, mimicking the fibrous extracellular matrix structure, have large surface area and porosity, facilitating cell adhesion, migration, and proliferation, and accelerating the wound healing process. The spinning methods, including RJS, offer advantages such as easy handling and variability in process parameters. The review provides an overview of the concept, configuration, comparison to other spinning techniques, commonly used polymers, and relevant parameters in the manufacture of fibers for wound dressings.

PHARMACEUTICS (2022)

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Article Materials Science, Composites

Performance of polylactic acid/polycaprolactone/microcrystalline cellulose biocomposites with different filler contents and maleic anhydride compatibilization

Gaoyuan Ye et al.

Summary: In this study, PLA/PCL/MCC composites and PLA/PCL/MCC composite compatibilized by MA copolymer were prepared. The mechanical results showed that the strength and break elongation of the composites were improved after compatibilization. DSC analysis revealed that the crystallinity of the composites increased with MCC content. The 3D printed PLA/PLAma/PCL/5MCC composite exhibited good biocompatibility and adhesion with MCF-7 cells.

POLYMER COMPOSITES (2022)

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Article Biotechnology & Applied Microbiology

PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment

Ruiming Liang et al.

Summary: In this study, lignin-based nanofibers were developed as antioxidative scaffolds for cartilage tissue engineering. The nanofibers showed the ability to protect cells from oxidative stress and promote cartilage regeneration. These findings suggest that lignin nanofibers could be used for the treatment of osteoarthritis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications

Zia Ullah Arif et al.

Summary: This article systematically summarizes the recent advancements in PLA and PCL biodegradable polymer-based composites manufactured through 3DP, as well as their applications in bone, cardiac, neural, vascularized and skin tissue regeneration. The interaction between implanted polymers and evaluation methods are also illustrated. The final section discusses the current challenges and future opportunities in 3DP of PCL and PLA-based composites for biomedical engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Polymer Science

Role of Maleic Anhydride-Grafted Poly(lactic acid) in Improving Shape Memory Properties of Thermoresponsive Poly(ethylene glycol) and Poly(lactic acid) Blends

Wasana Nonkrathok et al.

Summary: In this study, the shape memory properties of poly(lactic acid) (PLA)/poly(ethylene glycol) (PEG) blends were improved by adding maleic anhydride-grafted poly(lactic acid) (PLA-g-MA) as a compatibilizer. The PLA-g-MA improved interfacial adhesion between phases and promoted chain entanglement, leading to enhanced mechanical properties and shape fixity performance. The compatibilized blend containing 2 wt% PLA-g-MA exhibited the best shape fixity and recovery performance.

POLYMERS (2022)

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Review Biotechnology & Applied Microbiology

A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering

Claudia C. Miranda et al.

Summary: Chronic kidney disease is a global deadly disease and current treatment methods are insufficient. Engineering kidney tissues from induced pluripotent stem cells (iPSCs) could provide a solution, but implementation is challenging due to the complexity of mature kidneys. Electrospinning, a technique using synthetic and natural polymers to create fibers, shows promise in kidney tissue engineering. However, further research is needed to advance the applications of electrospinning in combination with other manufacturing methods.

BIOENGINEERING-BASEL (2022)

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Review Cell Biology

Mechanisms underlying lactic acid tolerance and its influence on lactic acid production in Saccharomyces cerevisiae

Arne Peetermans et al.

Summary: One of the main challenges in lactic acid production through microbial fermentation is the negative impact of lactic acid accumulation on the producing cells. This review extensively discusses how Saccharomyces cerevisiae addresses these issues and explores different strategies, both targeted and non-targeted, to improve lactic acid tolerance.

MICROBIAL CELL (2021)

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Review Chemistry, Multidisciplinary

Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels

Victoria G. Muir et al.

Summary: Biopolymers are natural polymers sourced from plants and animals, with inherent biochemical and biophysical properties that make them suitable for biomedical hydrogels. Various chemical modifications and cross-linking methods are used to design and develop biopolymer hydrogels for applications such as tissue scaffolds, therapeutic delivery, and tissue adhesives. Recent advances in the field include the use of chemically modified biopolymer hydrogels and interpenetrating network biopolymer hydrogels.

CHEMICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Shiyong Huang et al.

Summary: Lactic acid is an important organic acid with broad industrial applications, and microbial fermentation is the main route for its production. The main challenge in production is the high cost of substrates. Utilizing inexpensive substrates for lactic acid production is a potential solution to reduce costs.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Hydrolytic Degradation of Polylactic Acid Fibers as a Function of pH and Exposure Time

Radhika Vaid et al.

Summary: This study investigates the hydrolytic degradation of PLA fibers at various pH values and exposure times. The results show that degradation occurs at a faster rate in alkaline conditions, leading to an increase in crystallinity in the degraded samples.

MOLECULES (2021)

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Review Crystallography

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Hui Shi et al.

Summary: Hydroxyapatite is widely used in bone tissue engineering for its bioactivity and biocompatibility, with researchers exploring ways to improve its physical properties and biological functions. Functionalized HA has been prepared using methods such as ion doping and surface modification, and applications in bone tissue engineering have been discussed in this review. The review provides a general understanding of the development of hydroxyapatite-based materials for researchers.

CRYSTALS (2021)

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Article Multidisciplinary Sciences

Multi-product biorefinery from Arthrospira platensis biomass as feedstock for bioethanol and lactic acid production

Diego A. Esquivel-Hernandez et al.

Summary: This study investigated the production of ethanol and lactic acid from the biomass of cyanobacterium Arthrospira platensis through fermentation. Critical economic factors include fermentation scale, equipment cost, and product titer. As scale increases, production costs per unit of product sharply decrease.

SCIENTIFIC REPORTS (2021)

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Article Materials Science, Multidisciplinary

Degradation mechanisms and acceleration strategies of poly (lactic acid) scaffold for bone regeneration

Pei Feng et al.

Summary: This study systematically analyzed the degradation mechanisms and influencing factors of PLA bone scaffold, summarized strategies and mechanisms to accelerate degradation, and introduced the role of rapid prototyping technologies in scaffold structures.

MATERIALS & DESIGN (2021)

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Article Engineering, Biomedical

Effect of a plasma synthesized polypyrrole coverage on polylactic acid/hydroxyapatite scaffolds for bone tissue engineering

Maria G. Flores-Sanchez et al.

Summary: The study involved creating electrospun matrices consisting of polylactic acid (PLA) and hydroxyapatite (HA) to promote osteoconductive properties and porosity, while enhancing the growth and osteogenic differentiation of rabbit bone marrow stem cells through plasma polymerization. The matrices contained nano and microfibers with various pore sizes, allowing nutrients to pass through to bone cells, coated with polypyrrole doped with iodine to improve cell proliferation and viability. Results suggest that the PLA/HA/Pyrrole/Iodine matrices are beneficial for bone tissue engineering.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Review Biotechnology & Applied Microbiology

Metabolism Characteristics of Lactic Acid Bacteria and the Expanding Applications in Food Industry

Yaqi Wang et al.

Summary: Lactic acid bacteria, through fermenting carbohydrates to produce lactic acid, can improve the taste and nutritional value of food, prolong shelf life, and serve as probiotics for promoting human health.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Polymer Science

4D printing of shape memory polylactic acid (PLA)

Mehrshad Mehrpouya et al.

Summary: Additive manufacturing, particularly in the form of 4D printing, has gained significant attention in recent years for enabling the production of parts with time-dependent shapes and responses to environmental stimuli. The use of materials like polylactic acid (PLA) polymer, known for its great shape memory behavior, allows for the design and manufacturing of a wide range of smart products through 4D printing techniques. Research has focused on exploring the material properties, self-folding structures, and impact of design and printing conditions on the functionality of final printed products using PLA for 4D printing.

POLYMER (2021)

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Review Materials Science, Biomaterials

Biomimetic hydrogels designed for cartilage tissue engineering

Kresanti D. Ngadimin et al.

Summary: Cartilage regeneration and repair present a clinical challenge due to limited self-regenerative capability, with costs estimated at around 30,000 pounds per patient for producing and supplying cells. Regenerative approaches include cell therapies and tissue engineering using hydrogels as 3D substrates for cartilage cell cultivation, but current biomimetic hydrogels with necessary biological and physicochemical properties have yet to succeed.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Ceramics

Hydroxyapatite nano bioceramics optimized 3D printed poly lactic acid scaffold for bone tissue engineering application

Sudip Mondal et al.

CERAMICS INTERNATIONAL (2020)

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Review Chemistry, Multidisciplinary

Lignin-Based Micro- and Nanomaterials and their Composites in Biomedical Applications

Rui Liu et al.

CHEMSUSCHEM (2020)

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Article Polymer Science

Hybrid Bilayer PLA/Chitosan Nanofibrous Scaffolds Doped with ZnO, Fe3O4, and Au Nanoparticles with Bioactive Properties for Skin Tissue Engineering

Julia Radwan-Praglowska et al.

POLYMERS (2020)

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Review Nutrition & Dietetics

Lactic Acid Fermentation of Cereals and Pseudocereals: Ancient Nutritional Biotechnologies with Modern Applications

Penka Petrova et al.

NUTRIENTS (2020)

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Article Polymer Science

3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2/Au/Pt NPs with Tunable Properties for Guided Bone Tissue Engineering

Julia Radwan-Praglowska et al.

POLYMERS (2020)

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Article Materials Science, Multidisciplinary

In vitro evaluation of Zeolite-nHA blended PCL/PLA nanofibers for dental tissue engineering

Sanam Mohandesnezhad et al.

MATERIALS CHEMISTRY AND PHYSICS (2020)

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Article Biotechnology & Applied Microbiology

Lignin-graft-PLGA drug-delivery system improves efficacy of MEK1/2 inhibitors in triple-negative breast cancer cell line

C. Ethan Byrne et al.

NANOMEDICINE (2020)

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Review Biochemistry & Molecular Biology

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Sathish Sundar Dhilip Kumar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Engineering, Chemical

A review on degradation mechanisms of polylactic acid: Hydrolytic, photodegradative, microbial, and enzymatic degradation

Nor Fasihah Zaaba et al.

POLYMER ENGINEERING AND SCIENCE (2020)

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Article Materials Science, Multidisciplinary

Study on the properties of PLA/PBAT composite modified by nanohydroxyapatite

Dongsheng Yan et al.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2020)

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Review Engineering, Biomedical

Application of electrospun nanofibers in bone, cartilage and osteochondral tissue engineering

Huixiu Ding et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

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Review Nanoscience & Nanotechnology

Role of Hydrogels in Bone Tissue Engineering: How Properties Shape Regeneration

Yanting Wu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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Article Green & Sustainable Science & Technology

Properties of non-woven polylactic acid fibers prepared by the rotational jet spinning method

W. Rodchanasuripron et al.

MATERIALS TODAY SUSTAINABILITY (2020)

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Article Chemistry, Multidisciplinary

Novel Nanocomposite PLA Films with Lignin/Zinc Oxide Hybrids: Design, Characterization, Interaction with Mesenchymal Stem Cells

Francesca Luzi et al.

NANOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

Preparation of nanofibre material based on electrospinning technology and its application in rehabilitation of lower limb joint motion

Naxin Zhang

INTERNATIONAL JOURNAL OF NANOTECHNOLOGY (2020)

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Article Biophysics

Biodegradable poly (lactic acid-co-trimethylene carbonate)/chitosan microsphere scaffold with shape-memory effect for bone tissue engineering

Xulin Hu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Multidisciplinary Sciences

Lactic acid production - producing microorganisms and substrates sources-state of art

Elahe Abedi et al.

HELIYON (2020)

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Review Biochemistry & Molecular Biology

Polypyrrole-Incorporated Conducting Constructs for Tissue Engineering Applications: A Review

Yeshi Liang et al.

BIOELECTRICITY (2020)

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Article Materials Science, Ceramics

Highly loaded hydroxyapatite microsphere/PLA porous scaffolds obtained by fused deposition modelling

Carola Esposito Corcione et al.

CERAMICS INTERNATIONAL (2019)

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Review Engineering, Biomedical

Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients

Alireza Dehqan Niri et al.

ARTIFICIAL ORGANS (2019)

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Article Biochemistry & Molecular Biology

Effect of Co-Inoculation with Saccharomyces cerevisiae and Lactic Acid Bacteria on the Content of Propan-2-ol, Acetaldehyde and Weak Acids in Fermented Distillery Mashes

Katarzyna Pielech-Przybylska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Nanoscience & Nanotechnology

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Bio-based composite fibers from pine essential oil and PLA/PBAT polymer blend. Morphological, physicochemical, thermal and mechanical characterization

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