4.6 Article

Pharmacogenetic Analysis of the MIR146A rs2910164 and MIR155 rs767649 Polymorphisms and Response to Anti-TNF Treatment in Patients with Crohn's Disease and Psoriasis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles

Jaime A. Castro-Mondragon et al.

Summary: JASPAR is an open-access database containing manually curated, non-redundant transcription factor binding profiles across six taxonomic groups. The latest release introduces new profiles for plants, vertebrates, urochordates, and insects, as well as new tools for TFBS enrichment analysis and data access. The database can be accessed through various platforms, including the JASPAR website, RESTful API, R/Bioconductor data package, and a new Python package pyJASPAR.

NUCLEIC ACIDS RESEARCH (2022)

Article Gastroenterology & Hepatology

Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2

Jan K. Nowak et al.

Summary: This study uses whole-blood transcriptomic analysis to investigate the pathobiology of inflammatory bowel disease (IBD) and its potential translational implications.

JOURNAL OF CROHNS & COLITIS (2022)

Article Biotechnology & Applied Microbiology

Pharmacogenetic analysis of canonical versus noncanonical pathway of NF-kB in Crohn's disease patients under anti-tumor necrosis factor-α treatment

Eleana F. Stavrou et al.

Summary: This study suggests that gene polymorphisms in the canonical NF-kB pathway genes could potentially act as a predictive biomarker of anti-TNF alpha response in Crohn's disease (CD) patients.

PHARMACOGENETICS AND GENOMICS (2022)

Review Biochemistry & Molecular Biology

Contribution of the Environment, Epigenetic Mechanisms and Non-Coding RNAs in Psoriasis

Charalabos Antonatos et al.

Summary: This review provides an overview of the environmental factors, epigenetic modifications, and non-coding RNAs associated with the onset and progression of psoriasis. It also discusses therapeutic applications targeting the epigenome to suppress the inflammatory cutaneous cascade.

BIOMEDICINES (2022)

Review Biochemistry & Molecular Biology

miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review

Karina Maciak et al.

Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Pharmacogenetics of Biological Agents Used in Inflammatory Bowel Disease: A Systematic Review

Rita Lauro et al.

Summary: Inflammatory Bowel Disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC) and is primarily treated with anti-inflammatory drugs, with a recent increase in the use of biological drugs. This review focuses on summarizing the pharmacogenetics of biological drugs approved for IBD, highlighting the association between certain polymorphisms and drug response in patients.

BIOMEDICINES (2021)

Review Oncology

The role of epigenetic modifications for the pathogenesis of Crohn's disease

M. Hornschuh et al.

Summary: Epigenetics plays a crucial role in inflammatory bowel diseases, particularly in Crohn's disease, which is believed to be a result of a complex interplay between genetic susceptibility, environmental factors, and altered intestinal microbiota. While many genetic variants have been associated with Crohn's disease, the influence of epigenetics in its pathogenesis remains relatively unknown.

CLINICAL EPIGENETICS (2021)

Review Genetics & Heredity

Pharmacogenomics: An Update on Biologics and Small-Molecule Drugs in the Treatment of Psoriasis

Valerio Caputo et al.

Summary: Pharmacogenomic studies have shed light on the reasons behind different responses to treatments, leading to a decrease in adverse drug reactions and an improvement in drug efficacy. Current research on the pharmacogenomics of biologics and small-molecule treatments for psoriasis has produced conflicting results, indicating the need for further investigation to establish biomarkers for clinical use.

GENES (2021)

Review Biochemistry & Molecular Biology

Roles of microRNAs in inflammatory bowel disease

HyunTaek Jung et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Medicine, Research & Experimental

Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes

Ioanna Papathanasiou et al.

ADVANCES IN MEDICAL SCIENCES (2020)

Article Dermatology

Genome-wide association analysis of psoriasis patients treated with anti-TNF drugs

Maria C. Ovejero-Benito et al.

EXPERIMENTAL DERMATOLOGY (2020)

Review Biology

Pathophysiology of Crohn's disease inflammation and recurrence

L. Petagna et al.

BIOLOGY DIRECT (2020)

Article Immunology

Upregulation of the miRNA-155, miRNA-210, and miRNA-20b in psoriasis patients and their relation to IL-17

Mohamed El-Komy et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2020)

Article Endocrinology & Metabolism

Gene polymorphism and plasma levels of miR-155 in diabetic retinopathy

E. R. Polina et al.

ENDOCRINE CONNECTIONS (2019)

Article Medicine, Research & Experimental

Genetics of psoriasis: a basis for precision medicine

Delin Ran et al.

PRECISION CLINICAL MEDICINE (2019)

Review Biochemistry & Molecular Biology

Anti-TNF Therapy in Crohn's Disease

Samuel O. Adegbola et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Dermatology

TNF inhibitors for psoriasis

Margot Chima et al.

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY (2018)

Review Immunology

Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon

Alessio Mylonas et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Gastroenterology & Hepatology

Crohn's Disease Genetics Update

Ming-Hsi Wang et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2017)

Review Medicine, General & Internal

Crohn Disease: Epidemiology, Diagnosis, and Management

Joseph D. Feuerstein et al.

MAYO CLINIC PROCEEDINGS (2017)

Article Multidisciplinary Sciences

NF-kappa B activation correlates with disease phenotype in Crohn's disease

Yoo Min Han et al.

PLOS ONE (2017)

Review Pharmacology & Pharmacy

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics

Ping Li et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Cell Biology

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

You Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Review Immunology

Regulation of NF-κB by TNF family cytokines

Matthew S. Hayden et al.

SEMINARS IN IMMUNOLOGY (2014)

Review Immunology

MicroRNA-146a: a dominant, negative regulator of the innate immune response

Reuben Saba et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Biochemical Research Methods

FIMO: scanning for occurrences of a given motif

Charles E. Grant et al.

BIOINFORMATICS (2011)

Article Immunology

Epigenetics and autoimmunity

Wesley H. Brooks et al.

JOURNAL OF AUTOIMMUNITY (2010)

Article Rheumatology

Expression of MicroRNA-146 in rheumatoid arthritis synovial tissue

Tomoyuki Nakasa et al.

ARTHRITIS AND RHEUMATISM (2008)

Review Gastroenterology & Hepatology

Pharmacogenetics in inflammatory bowel disease

Marie Pierik et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2006)