☆ 4.7 Review

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

FRONTIERS IN PHARMACOLOGY (2023)

Related references

Note: Only part of the references are listed.
Article Oncology

Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner

Yuan Gao et al.

Summary: This study found that circ_0007841 induces DDP resistance in OC cells through regulation of the miR-532-5p/NFIB pathway and is secreted from DDP-resistant OC cells via exosomes. This suggests that circ_0007841 has the potential to be a therapeutic target for OC.

JOURNAL OF CHEMOTHERAPY (2023)

Add to Collection
Review Chemistry, Multidisciplinary

Extracellular Vesicles as Delivery Shippers for Noncoding RNA-Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer

Yongli Pan et al.

Summary: Ischemic stroke and systemic cancer are leading causes of mortality. Both conditions involve hypoxia and angiogenesis regulation. Recent evidence suggests that extracellular vesicles (EVs) and noncoding RNAs (ncRNAs) play important roles in modulating angiogenesis and can be potential diagnostic, prognostic, and therapeutic agents.

SMALL (2023)

Add to Collection
Review Medicine, Research & Experimental

Effect of circular RNAs and N6-methyladenosine (m6A) modification on cancer biology

Gong Zhang et al.

Summary: This study aimed to review the interactions between m6A modification and circRNAs and illustrate their roles in tumorigenesis. m6A modification can modulate the biogenesis, translation, cytoplasmic export, degradation, and other functions of circRNAs in different tumors. circRNAs can also modulate m6A modification by affecting writers, erasers, and readers.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Add to Collection
Correction Oncology

Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression (vol 426, pg 37, 2018)

Meixiang Sang et al.

CANCER LETTERS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis

Yan Zhang et al.

Summary: The study revealed that circular RNA circ_0006174 plays a crucial role in doxorubicin chemoresistance in colorectal cancer, where it enhances chemoresistance by upregulating the miR-1205/CCND2 axis via exosomal transfer.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

Add to Collection
Article Oncology

CircRNA_0044556 diminishes the sensitivity of triple-negative breast cancer cells to adriamycin by sponging miR-145 and regulating NRAS

Jingjing Chen et al.

Summary: This study reveals that circRNA_0044556 promotes cell viability, ADM resistance, and migration while inhibiting apoptosis in TNBC cells by sponging miR-145. CircRNA_0044556 is negatively correlated with miR-145 and positively correlated with NRAS, indicating its negative regulatory effects on miR-145. Additionally, circRNA_0044556 diminishes the sensitivity of TNBC cells to ADM via the miR-145/NRAS axis.

MOLECULAR MEDICINE REPORTS (2022)

Add to Collection
Article Biotechnology & Applied Microbiology

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/nuclear factor -kappa B (NF-κB) pathway

Yun Zhou et al.

Summary: The study found that CAFs-derived exosomes deliver circZFR to HCC cells, promoting HCC development and chemoresistance.

BIOENGINEERED (2022)

Add to Collection
Review Oncology

Circular RNAs and Drug Resistance in Genitourinary Cancers: A Literature Review

Gongwei Long et al.

Summary: This review focuses on the role of circular RNAs (circRNAs) in drug resistance in genitourinary tumors and summarizes the underlying mechanisms. It highlights the essential role of circRNAs in drug resistance development and points out potential future research directions. The potential clinical prospect of circRNAs in regulating tumor drug resistance is also discussed.

CANCERS (2022)

Add to Collection
Review Cell Biology

The Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer

Man Wang et al.

Summary: Chemoresistance is a major clinical problem in GI cancer treatment, and the underlying mechanisms are still unclear. Recent studies have shown that circRNAs play a key role in GI cancer chemoresistance, acting as molecular sponges to indirectly control gene expression. Hence, circRNAs may serve as therapeutic targets for overcoming GI cancer drug resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection
Article Pharmacology & Pharmacy

Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis

Hongya Xie et al.

Summary: This study reveals the regulatory mechanism of circRNA circVMP1 in NSCLC progression and cisplatin resistance. circVMP1 promotes the malignant behavior and cisplatin resistance of NSCLC through the miR-524-5p-METTL3/SOX2 axis targeting.

DRUG DELIVERY (2022)

Add to Collection
Article Immunology

Tumor-derived or non-tumor-derived exosomal noncodingRNAs and signaling pathways in tumor microenvironment

Yiwen Wu et al.

Summary: This review summarizes the regulatory functions of exosomal noncoding RNAs (ncRNAs) in the tumor microenvironment (TME), focusing on their detailed molecular mechanisms in modulating both tumor and non-tumor cells through various signaling pathways. Exosomal ncRNAs are considered as potential biomarkers and therapeutic targets in the diagnosis and prognosis of cancer.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection
Review Oncology

Energy Sources for Exosome Communication in a Cancer Microenvironment

Abhimanyu Thakur et al.

Summary: Exosomal communication in the tumor microenvironment is crucial for cancer development, progression, and metastasis. Exosomes can communicate with neighboring cells or distant organs, promoting tumor growth and cancer progression. Recent studies have identified potential energy sources for exosomes, including mitochondria, adenosine triphosphate, and glycolytic enzymes. This review emphasizes the importance of exosome energy sources and how they maintain structural integrity and stability during communication.

CANCERS (2022)

Add to Collection
Article Engineering, Biomedical

Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

Abhimanyu Thakur et al.

Summary: Exosomes are tiny extracellular vesicles that carry various components, such as proteins, lipids, and nucleic acids, and play a crucial role in the malignant progression of cancer. Due to their ability to transport drugs and molecular information, exosomes have been considered as a novel tool for cancer therapeutics.

BIOACTIVE MATERIALS (2022)

Add to Collection
Article Radiology, Nuclear Medicine & Medical Imaging

Exosome-Derived Circ_0094343 Promotes Chemosensitivity of Colorectal Cancer Cells by Regulating Glycolysis via the miR-766-5p/TRIM67 Axis

Chen Li et al.

Summary: The study found that circ_0094343 could inhibit the proliferation, clone formation, and glycolysis of CRC cells via the miR-766-5p/TRIM67 axis, and improve their chemosensitivity to various chemotherapeutic drugs.

CONTRAST MEDIA & MOLECULAR IMAGING (2022)

Add to Collection
Article Cell Biology

Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma

Xiuchao Geng et al.

Summary: The delivery of circWDR62 through exosomes promotes TMZ-resistance and malignant progression in glioma by targeting the miR-370-3p/MGMT axis, providing a new therapeutic strategy. Exosomal circWDR62 in human serum may serve as a promising therapeutic target and prognostic marker for glioma therapy.

CELL DEATH & DISEASE (2022)

Add to Collection
Article Oncology

Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-κB activating protein

Yuxin He et al.

Summary: Exosomes derived from gastric cancer cells carry circRNA circPRRX1, which plays a role in gastric tumorigenesis and radiation sensitivity. CircPRRX1 regulates cell biological functions through miR-596 and modulates NKAP expression by acting as a ceRNA. This study reveals a new mechanism in the regulation of gastric cancer and radiation sensitivity.

ANTI-CANCER DRUGS (2022)

Add to Collection
Article Oncology

Exosomal circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) enhances the docetaxel resistance of prostate cancer via the microRNA-136-5p/tribbles homolog 1 pathway

Xiaoliang Tan et al.

Summary: Exosomal circular RNA circ-SFMBT2 was found to enhance the chemoresistance of prostate cancer cells to docetaxel through the miR-136-5p/TRIB1 axis. Circ-SFMBT2 was highly expressed in the serum of docetaxel-resistant prostate cancer patients.

ANTI-CANCER DRUGS (2022)

Add to Collection
Article Oncology

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR

Xiaolong Wang et al.

Summary: Our study revealed the downregulation of circRNA-CREIT in doxorubicin resistant TNBC cells and its association with poor prognosis. We identified the RNA binding protein DHX9 as responsible for the reduction in circRNA-CREIT by interacting with the flanking inverted repeat Alu (IRAlu) sequences and inhibiting back-splicing. Mechanistically, circRNA-CREIT acted as a scaffold to facilitate the interaction between PKR and the E3 ligase HACE1, leading to proteasomal degradation of PKR protein via K48-linked polyubiquitylation and attenuation of the assembly of stress granules (SGs) to activate the RACK1/MTK1 apoptosis signaling pathway. Moreover, circRNA-CREIT could be packaged into exosomes and disseminate doxorubicin sensitivity among TNBC cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Add to Collection
Article Oncology

Exosomal Circ-HIPK3 Facilitates Tumor Progression and Temozolomide Resistance by Regulating miR-421/ZIC5 Axis in Glioma

Chengchen Han et al.

Summary: In glioma, high expression of circ-HIPK3 was found in TMZ-resistant cells and their exosomes, while miR-421 was downregulated. Circ-HIPK3 directly targeted miR-421, and their expressions were negatively correlated in glioma tissues. The results suggest that circ-HIPK3 promotes cell progression and TMZ resistance by modulating the miR-421/ZIC5 axis in TMZ-resistant glioma.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2021)

Add to Collection
Article Biophysics

In vivo liquid biopsy for glioblastoma malignancy by the AFM and LSPR based sensing of exosomal CD44 and CD133 in a mouse model

Abhimanyu Thakur et al.

Summary: Lactate-driven upregulation of CD44 enhances the release of CD44-enriched exosomes in malignant Glioblastoma cells, promoting tumor progression. Sensitive detection and quantification of enhanced CD44 and CD133 levels in immunocaptured exosomes using TiN-NH-LSPR biosensors support its potential application in minimally invasive molecular diagnostics for GBM progression.

BIOSENSORS & BIOELECTRONICS (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Factors Affecting Extracellular Vesicles Based Drug Delivery Systems

Isha Gaurav et al.

Summary: This review summarizes recent studies on the development of EV-based DDS and its advantages compared to conventional NDDS. It compares liposomes and exosomes in terms of their distinct benefits in DDS, analyzes considerations for better isolation and characterization of EVs for DDS, summarizes different methods for EV surface modification, discusses different origins of EVs and their role in developing DDS, includes major methods for encapsulating therapeutic cargos in EVs, and highlights key challenges and important open questions for further investigation in developing more effective EV-based DDS.

MOLECULES (2021)

Add to Collection
Article Cell Biology

Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis

Jing Yang et al.

Summary: The circRNA circUBE2Q2 is upregulated in gastric cancer and promotes tumor progression via the circUBE2Q2-miR-370-3p-STAT3 axis, as well as tumor metastasis through exosomal communication. Silencing circUBE2Q2 inhibits proliferation, migration, invasion, and increases autophagy in gastric cancer cells. Combination treatment of circUBE2Q2 knockdown and STAT3 inhibitor has synergistic effects on inhibiting gastric cancer growth.

CELL DEATH & DISEASE (2021)

Add to Collection
Review Oncology

Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway

Qun Lai et al.

Summary: The rapid increase in cancer morbidity and mortality worldwide presents a major challenge for public health providers, highlighting the urgent need to explore tumorigenesis mechanisms and identify diagnostic biomarkers. CircRNA, with its stable structure and tissue-specific expression, shows potential in medical research and clinical applications, particularly in cancer prognosis and treatment. Abnormal circRNA expression can disrupt specific signaling pathways like the MAPK pathway, offering potential diagnostic biomarkers and therapeutic targets.

ONCOLOGY LETTERS (2021)

Add to Collection
Article Cell Biology

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

Bo Yang et al.

Aging-US (2021)

Add to Collection
Review Oncology

The Role of Circular RNAs in DNA Damage Response and Repair

Angelos Papaspyropoulos et al.

Summary: The text highlights the underappreciated role of non-coding RNAs, particularly circular RNAs, in the DNA damage response and repair network. It emphasizes the importance of further research in this area for potential therapeutic opportunities, while also acknowledging the lack of detailed understanding of the properties and functional roles of these molecules.

CANCERS (2021)

Add to Collection
Review Cell Biology

CircRNAs: role in human diseases and potential use as biomarkers

Lorena Verduci et al.

Summary: Circular RNAs (circRNAs) are a unique class of endogenous RNAs characterized by a covalent loop structure, high stability, and tissue specificity. Their main mode of action is sponging microRNAs, but they may also have the ability to bind specific proteins and encode short proteins. CircRNAs play various functional roles in human diseases, serving as potential biomarkers due to their stable nature and remarkable tissue specificity.

CELL DEATH & DISEASE (2021)

Add to Collection
Review Genetics & Heredity

Advances in the Identification of Circular RNAs and Research Into circRNAs in Human Diseases

Shihu Jiao et al.

Summary: circRNAs are a type of stable and widely present circular non-coding RNA in eukaryotes, playing crucial roles in gene expression regulation and biological functions, offering potential utility in disease diagnosis and treatment.

FRONTIERS IN GENETICS (2021)

Add to Collection
Review Genetics & Heredity

Investigating the Underlying Mechanisms of Circular RNAs and Their Application in Clinical Research of Cervical Cancer

Jian Liu et al.

Summary: circRNAs, a type of non-coding RNA molecules, play a regulatory role in diseases such as cancer, with potential as important factors in gene expression regulation. With their enrichment and potential as cancer biomarkers in body fluids, circRNAs are seen as promising targets for cancer diagnosis and treatment.

FRONTIERS IN GENETICS (2021)

Add to Collection
Article Oncology

The ever-increasing importance of cancer as a leading cause of premature death worldwide

Freddie Bray et al.

Summary: CVD and cancer are now leading causes of premature death in 127 countries with cancer poised to overtake CVD in most countries over the course of this century. Governments must consider these transitions in disease profiles when developing cancer policies at the local level.

CANCER (2021)

Add to Collection
Article Oncology

Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related myocardial damage

Runjie Sun et al.

Summary: This study investigated the role of exosomal circular RNAs (exo-circRNAs) in multiple myeloma (MM) related myocardial damage. Bioinformatics analysis revealed that upregulated circRNAs may promote MM-related myocardial damage. Cell experiments showed that the circ-G042080/hsa-miR-4268/TLR4 axis may exist in H9C2 cells and cause abnormal autophagy. Abnormal expression of serum exo-circRNAs was found to be associated with MM-related myocardial damage, suggesting their potential as diagnostic markers and therapeutic targets.

CANCER CELL INTERNATIONAL (2021)

Add to Collection
Review Genetics & Heredity

The Emerging Role of Non-coding RNAs in Drug Resistance of Ovarian Cancer

Hua Lan et al.

Summary: Ovarian cancer, a common gynecological malignancy with high mortality rate, can benefit from chemotherapy but drug resistance remains a challenge. ncRNAs, such as circular RNAs, long non-coding RNAs, and microRNAs, play important roles in ovarian cancer development and resistance to chemotherapy. Understanding the regulatory mechanisms by which ncRNAs affect chemoresistance may lead to new diagnostic and therapeutic strategies for ovarian cancer.

FRONTIERS IN GENETICS (2021)

Add to Collection
Article Genetics & Heredity

The Potential of Serum Exosomal hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer

Yuanxiao Wang et al.

Summary: Serum exosomal circular RNAs, especially hsa_circ_0028861, show promising diagnostic performance for HBV-derived HCC screening, with the ability to detect small, early-stage, and AFP-negative tumors. The combination of hsa_circ_0028861 and AFP improves diagnostic ability, and bioinformatics prediction suggests its potential influence on HCC progression through miRNA regulation.

FRONTIERS IN GENETICS (2021)

Add to Collection
Article Genetics & Heredity

Serum Exosomal Circular RNA Expression Profile and Regulative Role in Proliferative Diabetic Retinopathy

Xinsheng Li et al.

Summary: This study identified distinct exosomal circRNA expression in PDR serum and explored the potential pro-angiogenic mechanism. Bioinformatics analysis revealed enriched pathways and hub genes related to angiogenesis in PDR. CircFndc3b derived from high-glucose-induced endothelial cells may play a crucial role in angiogenesis in PDR.

FRONTIERS IN GENETICS (2021)

Add to Collection
Review Oncology

Insights into the Evolving Roles of Circular RNAs in Cancer

Katherine Louise Harper et al.

Summary: Circular RNAs (circRNAs) play vital roles in cellular processes, including gene expression modulation and protein interactions. Dysregulated circRNAs have a significant impact on disease progression, especially in cancer, potentially serving as novel therapeutic targets.

CANCERS (2021)

Add to Collection
Review Oncology

New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer

Giulia Fontemaggi et al.

Summary: circRNAs are a new class of non-coding RNAs that play a role in cellular functions and various diseases, especially in human cancer. They are involved in cancer progression and metastasis through multiple mechanisms, particularly as competing endogenous RNAs (ceRNAs) for miRNAs, lncRNAs, and mRNAs.

CANCERS (2021)

Add to Collection
Review Oncology

Exosomes in Lung Cancer: Actors and Heralds of Tumor Development

Amaia Sandua et al.

Summary: Lung cancer is a major cause of cancer-related deaths globally, with late detection and frequent treatment resistance being common issues. Exosomes, as microvesicles secreted by cells, especially tumor cells, play a crucial role in lung cancer development and can be utilized for diagnosis, prognosis, and follow-up. However, the isolation and analysis of exosomes can be challenging, yet their cargo proteins, RNA, and DNA provide valuable insights into lung cancer progression and management.

CANCERS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer

Isha Gaurav et al.

Summary: Peptides, consisting of amino acid strings, have gained significant attention in cancer research for their advantages, such as better biosafety and targeting ability. Conjugating peptides with nano delivery systems provides targeted delivery benefits for cancer therapy, and has potential for diagnosing malignant cancer progression.

PHARMACEUTICS (2021)

Add to Collection
Article Cell Biology

Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p

Rukun Zang et al.

Summary: The study revealed that exosomal circ_0000337 in esophageal cancer cells regulates CDDP resistance through the miR-377-3p/JAK2 axis, suggesting it as a potential therapeutic target for the treatment of esophageal cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection
Review Biochemistry & Molecular Biology

The Role of Exosomes and Their Applications in Cancer

Yuju Zhou et al.

Summary: Exosomes, small extracellular vesicles secreted by various cell types, have shown great potential in cancer therapy and diagnosis. They can deliver therapeutic molecules to tumor cells and serve as biomarkers for early cancer detection and treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology

Hui Nie et al.

Summary: Exosomal long non-coding RNAs play crucial roles in cancer metastasis and have the potential to serve as novel tumor markers and therapeutic targets.

GENES & DISEASES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Xi Liu et al.

Summary: Cancer is a major global health issue, with chemotherapy being the primary treatment option. Oridonin and its derivatives have shown promise in overcoming therapeutic resistance in cancer treatment, with potential as clinical trial drug candidates.

GENES & DISEASES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Emerging important roles of circRNAs in human cancer and other diseases

Yong Huang et al.

Summary: CircRNAs, distinguished by stable structure and high abundance, were once overlooked but have now become a research hotspot due to their special features. They function as miRNA sponges, interfere with splicing, and regulate the expression of parental genes.

GENES & DISEASES (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Identification of low-dose radiation-induced exosomal circ- METRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance

Xinxin Wang et al.

Summary: This study reveals the significant role of low-dose radiation-induced exosomal circ-METRN in the progression and radioresistance of glioblastoma, providing valuable insights into potential therapeutic targets.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities

Shuai Wang et al.

Summary: Exosomal circRNAs have emerged as potential biomarkers in cancer diagnosis and prognosis, with the ability to influence target cells or organs by regulating tumor development and metastasis. The high stability of circRNAs in exosomes makes them promising candidates for early and minimally invasive cancer diagnosis and prognosis evaluation.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Add to Collection
Review Gastroenterology & Hepatology

Recent advances in chemotherapy for pancreatic cancer: evidence from Japan and recommendations in guidelines

Takuji Okusaka et al.

JOURNAL OF GASTROENTEROLOGY (2020)

Add to Collection
Review Multidisciplinary Sciences

Neoadjuvant checkpoint blockade for cancer immunotherapy

Suzanne L. Topalian et al.

SCIENCE (2020)

Add to Collection
Article Cell Biology

circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma

JunFeng Wang et al.

CELL DEATH & DISEASE (2020)

Add to Collection
Article Medical Laboratory Technology

Novel potential tumor biomarkers: Circular RNAs and exosomal circular RNAs in gastrointestinal malignancies

Yezhao Wang et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

Add to Collection
Article Multidisciplinary Sciences

Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma

Rushdi S. Fadhil et al.

PLOS ONE (2020)

Add to Collection
Review Oncology

Role of Immunotherapy in Triple-Negative Breast Cancer

Tanya E. Keenan et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Xiao-Yong Huang et al.

MOLECULAR CANCER (2020)

Add to Collection
Review Oncology

Emerging Role of Circular RNAs in Cancer

Jing Liu et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection
Review Urology & Nephrology

Cellular rewiring in lethal prostate cancer: the architect of drug resistance

Marc Carceles-Cordon et al.

NATURE REVIEWS UROLOGY (2020)

Add to Collection
Article Oncology

被撤回的出版物: Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma (Retracted article. See vol. 533, 2022)

Chenyu Ding et al.

CANCER LETTERS (2020)

Add to Collection
Article Multidisciplinary Sciences

Label-free sensing of exosomal MCT1 and CD147 for tracking metabolic reprogramming and malignant progression in glioma

A. Thakur et al.

SCIENCE ADVANCES (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Peng-Fei Zhang et al.

MOLECULAR CANCER (2020)

Add to Collection
Review Pharmacology & Pharmacy

Drug resistance in cancer: mechanisms and tackling strategies

Tanweer Haider et al.

PHARMACOLOGICAL REPORTS (2020)

Add to Collection
Article Pharmacology & Pharmacy

N6-methyladenosine RNA modification in cancer therapeutic resistance: Current status and perspectives

Zhijie Xu et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Add to Collection
Article Medicine, Research & Experimental

circFN1 Mediates Sorafenib Resistance of Hepatocellular Carcinoma Cells by Sponging miR-1205 and Regulating E2F1 Expression

Cheng Yang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Add to Collection
Article Biochemistry & Molecular Biology

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Junjie Xu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Exosomes: key players in cancer and potential therapeutic strategy

Jie Dai et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection
Article Nanoscience & Nanotechnology

Inhibition of Glioma Cells' Proliferation by Doxorubicin-Loaded Exosomes via Microfluidics

Abhimanyu Thakur et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Macrophages: Key orchestrators of a tumor microenvironment defined by therapeutic resistance

Kristen B. Long et al.

MOLECULAR IMMUNOLOGY (2019)

Add to Collection
Article Medicine, Research & Experimental

CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis

Linli Tian et al.

CLINICAL SCIENCE (2019)

Add to Collection
Review Oncology

The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer

Yuanliang Yan et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Add to Collection
Review Biochemistry & Molecular Biology

Exosomal circRNAs: biogenesis, effect and application in human diseases

Yangxia Wang et al.

MOLECULAR CANCER (2019)

Add to Collection
Article Medicine, Research & Experimental

Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression

Zhao Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Add to Collection
Article Multidisciplinary Sciences

Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer

Kha Wai Hon et al.

SCIENTIFIC REPORTS (2019)

Add to Collection
Article Genetics & Heredity

Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer

Bei Pan et al.

FRONTIERS IN GENETICS (2019)

Add to Collection
Article Cell Biology

Novel Function of lncRNA ADAMTS9-AS2 in Promoting Temozolomide Resistance in Glioblastoma via Upregulating the FUS/MDM2 Ubiquitination Axis

Yuanliang Yan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Add to Collection
Review Oncology

Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer

Hongbo Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Add to Collection
Article Cell Biology

CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression

Yanwei Luo et al.

CELL DEATH DISCOVERY (2019)

Add to Collection
Article Oncology

Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer

Zhonghu Li et al.

CANCER LETTERS (2018)

Add to Collection
Article Cell Biology

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Si-Yu Zhao et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Add to Collection
Review Biochemistry & Molecular Biology

Profiling Prostate Cancer Therapeutic Resistance

Cameron A. Wade et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection
Article Oncology

Circular RNA: new star, new hope in cancer

Zikang Zhang et al.

BMC CANCER (2018)

Add to Collection
Article Genetics & Heredity

Screening circular RNA related to chemotherapeutic resistance in breast cancer

Danfeng Gao et al.

EPIGENOMICS (2017)

Add to Collection
Review Medical Laboratory Technology

Early Diagnosis of Oral Squamous Cell Carcinoma by Salivary microRNAs

Raluca Dumache

CLINICAL LABORATORY (2017)

Add to Collection
Article Biophysics

Direct detection of two different tumor-derived extracellular vesicles by SAM-AuNIs LSPR biosensor

Abhimanyu Thakur et al.

BIOSENSORS & BIOELECTRONICS (2017)

Add to Collection
Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

CELL (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

Jlenia Guarnerio et al.

CELL (2016)

Add to Collection
Article Multidisciplinary Sciences

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

Erika Lasda et al.

PLOS ONE (2016)

Add to Collection
Review Oncology

Targeted therapy in cancer

Apostolia-Maria Tsimberidou

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2015)

Add to Collection
Letter Cell Biology

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

Yan Li et al.

CELL RESEARCH (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Circular Intronic Long Noncoding RNAs

Yang Zhang et al.

MOLECULAR CELL (2013)

Add to Collection
Article Genetics & Heredity

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

Christin E. Burd et al.

PLOS GENETICS (2010)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.