4.7 Article

Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

The Blind Spot of Pharmacology: A Scoping Review of Drug Metabolism in Prematurely Born Children

Mette Louise Mork et al.

Summary: The pharmacokinetics of drugs in premature neonates, especially extremely premature ones, are not well understood. Existing studies often fail to distinguish between term and preterm children, making it difficult to interpret the results. Different approaches to measuring drug metabolism in preterm neonates have hindered formal meta-analyses. Optimized designs and collaborations between neonatologists and pharmacologists are needed for future research.

FRONTIERS IN PHARMACOLOGY (2022)

Review Pharmacology & Pharmacy

Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species

B. D. van Groen et al.

Summary: The liver plays a crucial role in detoxification and drug disposition, with drug transporters and drug-metabolizing enzymes influencing drug efficacy and toxicity. Differences in the ontogeny of these proteins across species and age groups provide insights for optimizing pediatric drug therapy.

PHARMACOLOGICAL REVIEWS (2021)

Article Pharmacology & Pharmacy

Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Gottingen Minipig: Pivotal Data for PBPK Modeling

Laura Buyssens et al.

Summary: The study assessed hepatic cytochrome P450 (CYP) protein abundance in developing Gottingen Minipigs and found various age and sex-related differences. The data provided valuable insights for constructing a neonatal and juvenile Gottingen Minipig PBPK model, showing correlations between CYP protein abundance and enzyme activity.

FRONTIERS IN PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Considerations for Drug Dosing in Premature Infants

John van den Anker et al.

Summary: Effective and safe drug therapy for premature infants relies on optimal dose selection and understanding of their underlying diseases and the pharmacokinetics/pharmacodynamics of selected drugs. Variability in drug disposition and effect in these infants is largely determined by differences in gestational and postnatal age or weight. Utilizing population pharmacokinetic/pharmacodynamic studies and physiologically based pharmacokinetic modeling can help tailor the safest and most effective dose for premature infants.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

Yasmine Elmorsi et al.

XENOBIOTICA (2020)

Article Pharmacology & Pharmacy

Dose-linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children

Bianca D. van Groen et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

In Vivo Metabolism of Ibuprofen in Growing Conventional Pigs: A Pharmacokinetic Approach

Joske Millecam et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Gastroenterology & Hepatology

Neonatal gut and immune maturation is determined more by postnatal age than by postconceptional age in moderately preterm pigs

Shuqiang Ren et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Anesthesiology

Negligible impact of birth on renal function and drug metabolism

Brian J. Anderson et al.

PEDIATRIC ANESTHESIA (2018)

Article Pharmacology & Pharmacy

Age-related change of hepatic uridine diphosphate glucuronosyltransferase and sulfotransferase activities in male chickens and pigs

S. X. Hu

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2017)

Article Chemistry, Multidisciplinary

In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Gottingen Minipigs

Els Van Peer et al.

PHARMACEUTICAL RESEARCH (2017)

Article Veterinary Sciences

Constitutive expression and activity of cytochrome P450 in conventional pigs

Soren Drud Nielsen et al.

RESEARCH IN VETERINARY SCIENCE (2017)

Article Physiology

Delayed growth, motor function and learning in preterm pigs during early postnatal life

Anders D. Andersen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

Article Pharmacology & Pharmacy

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children

Elizabeth Neumann et al.

FRONTIERS IN PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development

Natalie C. Sadler et al.

DRUG METABOLISM AND DISPOSITION (2016)

Article Pharmacology & Pharmacy

Age-related Differences in CYP3A Abundance and Activity in the Liver of the Gottingen Minipig

Els Van Peer et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2015)

Article Pharmacology & Pharmacy

Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future

Kate O'Hara et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Pharmacology & Pharmacy

Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig

Eriko Higashi et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2014)

Review Pediatrics

Understanding dosing: children are small adults, neonates are immature children

Brian J. Anderson et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2013)

Article Biochemistry & Molecular Biology

Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model

Emanuela Puccinelli et al.

CURRENT DRUG METABOLISM (2013)

Review Biochemistry & Molecular Biology

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

Andrew Rowland et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Review Pharmacology & Pharmacy

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

R. N. Hines

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Review Agriculture, Dairy & Animal Science

Invited Review: The preterm pig as a model in pediatric gastroenterology

P. T. Sangild et al.

JOURNAL OF ANIMAL SCIENCE (2013)

Article Multidisciplinary Sciences

A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics

Yvonne A. Eiby et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

Ontogeny of Hepatic Glucuronidation; Methods and Results

Elke H.J. Krekels et al.

CURRENT DRUG METABOLISM (2012)

Review Pharmacology & Pharmacy

Pharmacokinetics of Drugs in Neonates: Pattern Recognition Beyond Compound Specific Observations

Anne Smits et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Pharmacology & Pharmacy

Neonatal Development of Hepatic UGT1A9: Implications of Pediatric Pharmacokinetics

Shogo J. Miyagi et al.

DRUG METABOLISM AND DISPOSITION (2012)

Article Agriculture, Dairy & Animal Science

Reproductive cycles in pigs

N. M. Soede et al.

ANIMAL REPRODUCTION SCIENCE (2011)

Article Pharmacology & Pharmacy

The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver

Shogo J. Miyagi et al.

DRUG METABOLISM AND DISPOSITION (2011)

Article Chemistry, Analytical

Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS

Si-Cheng Liang et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2011)

Review Pharmacology & Pharmacy

Mechanism-based concepts of size and maturity in pharmacokinetics

B. J. Anderson et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2008)

Article Pharmacology & Pharmacy

Pediatric development of glucuronidation: The ontogeny of hepatic UGT1A4

Shogo J. Miyagi et al.

DRUG METABOLISM AND DISPOSITION (2007)

Article Pharmacology & Pharmacy

Epirubicin glucuronidation and UGT2B7 developmental expression

Matthew J. Zaya et al.

DRUG METABOLISM AND DISPOSITION (2006)

Review Medicine, Research & Experimental

Gut responses to enteral nutrition in preterm infants and animals

Per T. Sangild

EXPERIMENTAL BIOLOGY AND MEDICINE (2006)

Review Pediatrics

Ontogeny of drug metabolizing enzymes in the neonate

MJ Blake et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2005)

Article Anesthesiology

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children

NJ Bouwmeester et al.

BRITISH JOURNAL OF ANAESTHESIA (2004)

Article Pediatrics

Age terminology during the perinatal period

LR Blackmon et al.

PEDIATRICS (2004)

Review Medicine, Legal

Role of biokinetics in risk assessment of drugs and chemicals in children

LL de Zwart et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2004)

Review Medicine, General & Internal

Developmental pharmacology - Drug disposition, action, and therapy in infants and children

GL Kearns et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Pharmacology & Pharmacy

Pharmacokinetics and metabolism of oral midazolam in preterm infants

SN de Wildt et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)

Article Pharmacology & Pharmacy

Pharmacokinetics and metabolism of intravenous midazolam in preterm infants

SN de Wildt et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2001)

Review Pharmacology & Pharmacy

Neonatal hepatic drug elimination

PJ Gow et al.

PHARMACOLOGY & TOXICOLOGY (2001)