4.5 Article

Resveratrol suppresses neuroinflammation to alleviate mechanical allodynia by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of spinal cord injury

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer's Disease by Regulating Sirt1/miRNA-134/GSK3β Expression

Omayma A. R. Abozaid et al.

Summary: The study found that resveratrol-selenium nanoparticles (RSV-SeNPs) can improve oxidative stress and inflammation, alleviate neurochemical deficits and promote neurite outgrowth in an Alzheimer's disease model.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

Article Engineering, Biomedical

Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment

Xue Jiang et al.

Summary: This study aimed to design plasma complex component functionalized manganese-doped silica nanoparticles as a targeted drug carrier for resveratrol. The results showed that this drug delivery system effectively reduced oxidative stress, inflammation, and neuronal apoptosis in spinal cord tissue after spinal cord injury, promoting motor function recovery in mice.

MATERIALS TODAY BIO (2022)

Letter Biochemistry & Molecular Biology

Resveratrol may ameliorate rheumatoid arthritis via the STAT3/HIF-1/VEGF molecular pathway

Fereshteh Nazari-Khanamiri et al.

Summary: Rheumatoid arthritis is an autoimmune disease that causes destructive damage to bones and cartilage, resulting in pain, inflammation, and swelling. This study suggests that Resveratrol may have anti-rheumatoid arthritis effects by acting on the STAT3/HIF-1/VEGF pathway.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

Article Neurosciences

Receptor-Interacting Protein Kinase 3 Inhibition Relieves Mechanical Allodynia and Suppresses NLRP3 Inflammasome and NF-?B in a Rat Model of Spinal Cord Injury

Song Xue et al.

Summary: In this study, the researchers explored the role of RIPK3 in neuropathic pain after spinal cord injury (SCI). They found that RIPK3 played an important role in SCI-induced mechanical allodynia and that its inhibition could relieve the pain by suppressing NLRP3 inflammasome, NF-kappa B, and associated inflammation.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Article Immunology

Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

Yu-Ting Zhao et al.

Summary: This study found that the adaptation of PrL mediated by IL-6/STAT3/Acp5 pathway is associated with the comorbidity of neuropathic pain and depression induced by SNI.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Medicine, Research & Experimental

Resveratrol ameliorates oxaliplatin-induced neuropathic pain via anti-inflammatory effects in rats

Zhi-Bin Dong et al.

Summary: Oxaliplatin is a commonly used chemotherapy drug that can cause neurotoxicity, leading to sensory abnormalities and pain. In this study, researchers found that intrathecal injection of resveratrol can alleviate oxaliplatin-induced neuropathic pain by inhibiting spinal COX-2 and ROS production.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Article Pharmacology & Pharmacy

Resveratrol suppresses microglial activation and promotes functional recovery of traumatic spinal cord via improving intestinal microbiota

Ning He et al.

Summary: Spinal cord injury can alter the gut microbiota and metabolites, affecting the prognosis of the injury. Resveratrol, with its anti-inflammatory properties, can restore the disrupted gut microbiota and increase the concentration of butyrate, promoting functional recovery after spinal cord injury.

PHARMACOLOGICAL RESEARCH (2022)

Review Clinical Neurology

Emerging Evidence for Intrathecal Management of Neuropathic Pain Following Spinal Cord Injury

Jay Karri et al.

Summary: A high prevalence of patients with spinal cord injury (SCI) suffer from chronic neuropathic pain, but the exact pathophysiological mechanisms and targeted treatments are still unclear. Advances in SCI-specific animal studies and translational models have improved our understanding of the neuronal excitability, glial dysregulation, and chronic inflammation processes underlying neuropathic pain. Intrathecal drug delivery (IDD) has gained attention as a therapeutic strategy for chronic neuropathic pain in both preclinical and clinical contexts.

FRONTIERS IN PAIN RESEARCH (2022)

Review Biochemistry & Molecular Biology

Anti-Inflammatory Action and Mechanisms of Resveratrol

Tiantian Meng et al.

Summary: Resveratrol, a natural phytoalexin polyphenol, demonstrates antioxidant, anti-inflammatory, and anti-carcinogenic properties, with the ability to modulate inflammatory responses and exhibit immunomodulatory function both in vivo and in vitro.

MOLECULES (2021)

Review Anesthesiology

Prevalence of chronic pain after spinal cord injury: a systematic review and meta-analysis

Christine Hunt et al.

Summary: This systematic review and meta-analysis aimed to determine the prevalence of chronic pain after SCI based on the ISCIP system. The overall prevalence of chronic pain in SCI was found to be 68%, with neuropathic pain at 58%, musculoskeletal pain at 56%, visceral pain at 20%, and nociceptive pain at 45%. Certainty in prevalence estimates was judged to be low due to unexplained heterogeneity.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2021)

Article Immunology

Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

Xuankang Wang et al.

Summary: This study found that PBM can promote motor function recovery, inhibit the activation of neurotoxic microglia and astrocytes, alleviate neuroinflammation and tissue apoptosis, and increase the number of neurons retained after SCI. It was also observed that PBM can suppress the Lcn2/JAK2-STAT3 crosstalk involved in the activation of neurotoxic microglia and astrocytes after SCI.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Biophysics

Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury

Xuan-Qi Zheng et al.

Summary: The injectable PLGA-PEG-PLGA thermos-sensitive hydrogel containing Baricitinib (Bari-P hydrogel) reduced neuronal apoptosis and promoted functional recovery in spinal cord injured rats. By inhibiting the JAK2-STAT3 pathway and controlling the expression of inflammatory cytokines, the Bari-P hydrogel showed therapeutic potential.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Biochemistry & Molecular Biology

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved

C. A. Miguel et al.

Summary: Secondary damage is a key factor in promoting cell death, neurodegeneration, and functional deficits following acute central nervous system insults. Resveratrol, a natural compound found in grape skin and red wine, has shown potential neuroprotective effects by modulating multiple pathways involved in antioxidant, anti-inflammatory, and anti-apoptotic processes.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

TTP488 ameliorates NLRP3-associated inflammation, viability, apoptosis, and ROS production in an Alzheimer's disease cell model by mediating the JAK1/STAT3/NFκB/IRF3 pathway

Jie Xue et al.

Summary: This study investigated the role of TTP488 in the development of an Alzheimer's disease cell model, finding that TTP488 can reduce inflammation, apoptosis, and ROS production, and partially reverse the activation of pathways and NLRP3 expression induced by A beta.

CELL BIOCHEMISTRY AND FUNCTION (2021)

Article Medicine, Research & Experimental

Targeted inhibition of STAT3 in neural stem cells promotes neuronal differentiation and functional recovery in rats with spinal cord injury

Tingting Li et al.

Summary: The study demonstrated that inhibiting STAT3 can promote NSC neuronal differentiation and transplantation of NSCs with STAT3 knocked down holds promising potential for enhancing the benefit of NSC-mediated regenerative cell therapy for SCI.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Review Medicine, Research & Experimental

On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review

Sajad Fakhri et al.

Summary: This study discusses the molecular mechanisms and therapeutic targets for post-SCI pain, focusing on critical signaling pathways that could provide new insights into the clinical treatment of post-SCI pain.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Oncology

Resveratrol for cancer therapy: Challenges and future perspectives

Boxu Ren et al.

Summary: Despite its potential anticancer effects, resveratrol faces obstacles in clinical translation due to poor pharmacokinetics, low potency, and nephrotoxicity in certain patients. New strategies to enhance its bioavailability and develop more potent analogues are proposed to overcome these challenges and advance resveratrol in cancer therapy.

CANCER LETTERS (2021)

Article Neurosciences

Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses

Ruihua Fan et al.

Summary: The pathophysiological mechanisms of spinal cord injury are not well-defined, with neuroinflammation and astrocyte alterations playing key roles. Resveratrol has the potential to modulate neuroinflammatory factors and enhance injury recovery in spinal cord injury.

MOLECULAR NEUROBIOLOGY (2021)

Article Neurosciences

Resveratrol inhibits inflammation after spinal cord injury via SIRT-1/NF-κB signaling pathway

Haosen Zhao et al.

Summary: The study found that resveratrol treatment promoted motor function recovery in rats after SCI, increased the expression of brain-derived neurotrophic factor, and reduced loss of motor neurons and lesion size. Additionally, inflammatory response was inhibited by modulating the SIRT-1/NF-kappa B signaling pathway.

NEUROSCIENCE LETTERS (2021)

Article Immunology

Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition

Hua Zhu et al.

Summary: This study demonstrated that Ruxolitinib has a neuroprotective effect on ischemic stroke by inhibiting the JAK2/STAT3 signaling pathway, reducing the expression of NLRP3 inflammasome and alleviating stroke injury.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway

Yining Zhang et al.

Summary: Our study found that miR-21a-5p has effects on the induction of A1 astrocytes and revealed the potential mechanism. Additionally, CNTF was shown to inhibit the transformation of naive astrocytes into A1s.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Agriculture, Multidisciplinary

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Bingren Tian et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020)

Review Biochemistry & Molecular Biology

Resveratrol and Its Effects on the Vascular System

Johannes M. Breuss et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Clinical Neurology

Neuropathic pain and SCI: Identification and treatment strategies in the 21st century

Maya N. Hatch et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2018)

Review Biochemistry & Molecular Biology

The molecular details of cytokine signaling via the JAK/STAT pathway

Rhiannon Morris et al.

PROTEIN SCIENCE (2018)

Review Oncology

Do We Know Jack About JAK? A Closer Look at JAK/STAT Signaling Pathway

Emira Bousoik et al.

FRONTIERS IN ONCOLOGY (2018)

Article Medicine, Research & Experimental

Anti-interleukin-6 receptor antibody reduces neuropathic pain following spinal cord injury in mice

Tomotoshi Murakami et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

Review Clinical Neurology

Spinal Cord Injury Pain: Mechanisms and Management

Nanna Brix Finnerup et al.

CURRENT PAIN AND HEADACHE REPORTS (2012)

Review Neurosciences

Mechanisms of chronic central neuropathic pain after spinal cord injury

Claire E. Hulsebosch et al.

BRAIN RESEARCH REVIEWS (2009)

Article Rehabilitation

Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury

Andrew L. Davies et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2007)

Article Pharmacology & Pharmacy

Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain

Sameer Sharma et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2007)

Review Oncology

Small molecule inhibitors of Stat3 signaling pathway

Jinxia Deng et al.

CURRENT CANCER DRUG TARGETS (2007)

Article Biochemistry & Molecular Biology

JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia

Irawan Satriotomo et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Behavioral Sciences

Pharmacological evidence for the participation of NO-cyclic GMP-PKG-K+ channel pathway in the antiallodynic action of resveratrol

Deysi Y. Bermudez-Ocana et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)

Article Biochemistry & Molecular Biology

Activation of JAK/STAT signalling in neurons following spinal cord injury in mice

K Yamauchi et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Pharmacology & Pharmacy

High absorption but very low bioavailability of oral resveratrol in humans

T Walle et al.

DRUG METABOLISM AND DISPOSITION (2004)