4.5 Article

The senile plaque: Morphological differences in APP knock-in mice brains by fixatives

Related references

Note: Only part of the references are listed.
Review Neurosciences

Recent Advances in the Modeling of Alzheimer's Disease

Hiroki Sasaguri et al.

Summary: This article introduces transgenic mouse models of Alzheimer's disease (AD) and discusses their limitations and applications. The first generation models have artificial phenotypes, while the second generation models have specific strengths and weaknesses. The third generation models exhibit more pathology and are suitable for preclinical studies. The article also provides a technical guide for using App knock-in mice in AD research and discusses the latest advances in using human tau knock-in mice and non-human primate models of AD.

FRONTIERS IN NEUROSCIENCE (2022)

Article Geriatrics & Gerontology

β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice

Tanja Blume et al.

Summary: Clinical trials for BACE1 inhibitors in the treatment of AD have failed, but scientific evidence suggests that BACE1 inhibition could be an effective preventative measure. This study investigated the dose-dependent effects of BACE1 inhibition on dendritic spine dynamics in an AD mouse model and found that high-dose BACE1 inhibition improved spine dynamics.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Article Pathology

γ-Secretase Activity Is Associated with Braak Senile Plaque Stages

Nobuto Kakuda et al.

AMERICAN JOURNAL OF PATHOLOGY (2020)

Article Neurosciences

Single App knock-in mouse models of Alzheimer's disease

Takashi Saito et al.

NATURE NEUROSCIENCE (2014)