4.7 Article

Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC-QTOF-MS

Stine Lund Hansen et al.

Summary: Alternative brain tissue matrix can be used for drug screening in postmortem toxicology, as it shows comparable results to blood samples in detecting drugs and toxicological metabolites.

JOURNAL OF ANALYTICAL TOXICOLOGY (2023)

Article Biochemistry & Molecular Biology

Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus

Kira A. Perzel Mandell et al.

Summary: Antipsychotic drugs have abundant differences in gene expression in the human caudate nucleus, which are similar to gene expression differences between schizophrenia cases and controls. However, gene expression differences based on drug toxicology are different between brain regions, and there are also differences compared to a mouse model.

MOLECULAR PSYCHIATRY (2022)

Review Biochemistry & Molecular Biology

Schizophrenia: a disorder of broken brain bioenergetics

Nicholas D. Henkel et al.

Summary: A substantial body of literature suggests that deficits of bioenergetic function are related to the pathophysiology of schizophrenia. While antipsychotics are effective for positive symptoms, they are not efficacious for negative and cognitive symptoms. This review discusses the dysfunction of various metabolic pathways in different brain regions and suggests that deficits in bioenergetic subprocesses are a core feature of schizophrenia. Pharmacologic and nonpharmacologic interventions targeting these pathways are discussed as potential ways to improve symptoms.

MOLECULAR PSYCHIATRY (2022)

Article Multidisciplinary Sciences

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy et al.

Summary: In this study, a two-stage genome-wide association study was conducted to identify common variants associated with schizophrenia. The results revealed 287 distinct genomic loci and 120 genes likely to be involved in the development of schizophrenia. This research provides valuable insights into the pathophysiology of schizophrenia and offers a resource for further mechanistic studies.

NATURE (2022)

Article Neurosciences

Assessing the effects of antipsychotic medications on schizophrenia functional analysis: a postmortem proteome study

Rawan S. Alnafisah et al.

Summary: Antipsychotic drugs have a significant impact on postmortem studies of schizophrenia treatment. This study compares the effects of schizophrenia and antipsychotic drugs on the proteome to gain insight into the disease's pathophysiology. The findings reveal distinct changes in biological pathways, cell types, subcellular synaptic events, and drug targets between the two. The study identifies a hyperdopaminergic cortex and discusses the influence of drugs targeting cognitive symptoms on schizophrenia pathology.

NEUROPSYCHOPHARMACOLOGY (2022)

Article Psychiatry

Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder

Sujan C. Das et al.

Summary: It is found that both schizophrenia and bipolar disorder have molecular alterations at the mitochondrial and synaptic levels, leading to abnormal synaptic neurotransmission. The mitochondrial DNA copy number varies in different brain regions of patients, and the activity of complex I decreases. Additionally, the number of synapses is also reduced. Female patients have lower synaptic mitochondrial number.

TRANSLATIONAL PSYCHIATRY (2022)

Article Multidisciplinary Sciences

Upper cortical layer-driven network impairment in schizophrenia

Mykhailo Y. Batiuk et al.

Summary: Schizophrenia is a widespread and complex mental disorder characterized by a reduction in abundance of GABAergic neurons and an increase in principal neurons, especially in the upper cortical layers. Many neuronal subtypes show extensive transcriptomic changes, particularly in upper-layer GABAergic neurons. Transcription factor network analysis reveals the developmental origin of these transcriptomic changes.

SCIENCE ADVANCES (2022)

Article Neurosciences

A loss of mature microglial markers without immune activation in schizophrenia

Gijsje J. L. J. Snijders et al.

Summary: The density and morphology of microglial cells in schizophrenia patients were found to be unchanged, while the expression of several microglial-specific genes was decreased. This indicates a change in microglial phenotype rather than density, which could provide a crucial molecular hallmark for future research into the role of microglia in schizophrenia and other psychiatric disorders.
Article Neurosciences

Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study

Sidhant Chopra et al.

Summary: This study aimed to differentiate between illness-related brain volume changes and medication-related changes within the first 3 months of treatment. It was found that antipsychotic medication and placebo had different effects on the pallidum volume, with patients showing increased volume and healthy controls showing no change. This suggests that psychotic illness and antipsychotic exposure have distinct effects on brain volume.

NEUROPSYCHOPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

Xiaojun Wu et al.

Summary: The study revealed specific changes in neuronal immunity, synaptic dysfunction, and olfactory dysregulation in schizophrenia using laser-capture microdissection on brain samples, providing new insights for the cell-subtype specific pathophysiology of chronic schizophrenia.

MOLECULAR PSYCHIATRY (2021)

Article Psychiatry

Psychiatric drugs impact mitochondrial function in brain and other tissues

Shawna T. Chan et al.

SCHIZOPHRENIA RESEARCH (2020)

Article Multidisciplinary Sciences

U1 snRNP regulates cancer cell migration and invasion in vitro

Jung-Min Oh et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder

Gabriel E. Hoffman et al.

SCIENTIFIC DATA (2019)

Article Chemistry, Analytical

Reference Brain/Blood Concentrations of Citalopram, Duloxetine, Mirtazapine and Sertraline

Michael Nedahl et al.

JOURNAL OF ANALYTICAL TOXICOLOGY (2018)

Article Genetics & Heredity

Genetic identification of brain cell types underlying schizophrenia

Nathan G Skene et al.

NATURE GENETICS (2018)

Article Multidisciplinary Sciences

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Michael J. Gandal et al.

SCIENCE (2018)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Article Neurosciences

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer et al.

NATURE NEUROSCIENCE (2016)

Article Clinical Neurology

Schizophrenia Gene Expression Profile Reverted to Normal Levels by Antipsychotics

Benedicto Crespo-Facorro et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2015)

Article Chemistry, Analytical

Postmortem Quetiapine Reference Concentrations in Brain and Blood

Louise Skov et al.

JOURNAL OF ANALYTICAL TOXICOLOGY (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biotechnology & Applied Microbiology

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Charity W. Law et al.

GENOME BIOLOGY (2014)

Review Neurosciences

Losing your inhibition: Linking cortical GABAergic interneurons to schizophrenia

Melis Inan et al.

NEUROBIOLOGY OF DISEASE (2013)

Review Neurosciences

Psychiatric Brain Banking: Three Perspectives on Current Trends and Future Directions

Amy Deep-Soboslay et al.

BIOLOGICAL PSYCHIATRY (2011)

Article Biochemistry & Molecular Biology

Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients

M. K. Chan et al.

MOLECULAR PSYCHIATRY (2011)

Article Psychiatry

Hippocampal interneurons are abnormal in schizophrenia

Christine Konradi et al.

SCHIZOPHRENIA RESEARCH (2011)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Psychiatry

Effects of antipsychotics on brain structure

H Scherk et al.

CURRENT OPINION IN PSYCHIATRY (2006)