4.6 Review

Biosensors for the Isolation and Detection of Circulating Tumor Cells (CTCs) in Point-of-Care Settings

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

2D MOF Nanosensor-Integrated Digital Droplet Microfluidic Flow Cytometry for In Situ Detection of Multiple miRNAs in Single CTC Cells

Junyue Chen et al.

Summary: Current strategies for detecting circulating tumor cells (CTCs) based on surface epithelial markers have low specificity in distinguishing between CTCs and epithelial cells in the hematopoietic cell population. As tumor-associated miRNAs are highly correlated with tumor development and progression, they are emerging as new biomarkers. However, simultaneous analysis of multiple miRNAs in a single CTC cell is still challenging. In this study, a digital droplet microfluidic flow cytometry platform based on biofunctionalized 2D metal-organic framework nanosensors (Nano-DMFC) was developed for in situ detection of dual miRNAs simultaneously in single living breast cancer cells. This platform successfully detected dual miRNAs at single-cell resolution and showed good reproducibility in the recovery experiment of spiked blood samples, demonstrating its high potential for CTC-based cancer early diagnosis and prognosis.

SMALL (2022)

Review Medicine, General & Internal

Circulating tumor cell isolation for cancer diagnosis and prognosis

Zicheng Deng et al.

Summary: Circulating tumor cells (CTCs) play a crucial role in cancer diagnosis and prognosis. Current detection technologies have limitations due to tumor heterogeneity, but a new technique using superparamagnetic nanoprobe shows higher sensitivity and biomarker independence.

EBIOMEDICINE (2022)

Review Chemistry, Analytical

Microfluidic flow cytometry for blood-based biomarker analysis

Yuxin Zhang et al.

Summary: Microfluidic flow cytometry (MFCM), combining flow cytometry and microfluidics, provides a powerful tool for single-cell analysis and sorting of various biological samples. Recent progress and achievements have been made in analyzing blood-based biomarkers using MFCM.

ANALYST (2022)

Article Chemistry, Analytical

Development of a parallel three-dimensional microfluidic device for high-throughput cytometry

Yu-Jui Fan et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

Review Materials Science, Biomaterials

Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells

Pi Ding et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Article Biochemical Research Methods

Monitoring Circulating Tumor Cells in vivo by a Confocal Microscopy System

Yuhao Hu et al.

CYTOMETRY PART A (2019)

Article Chemistry, Analytical

Detection of circulating tumor cells based on improved SERS-active magnetic nanoparticles

Ting Xue et al.

ANALYTICAL METHODS (2019)

Review Biotechnology & Applied Microbiology

Circulating tumor cell isolation, culture, and downstream molecular analysis

Sandhya Sharma et al.

BIOTECHNOLOGY ADVANCES (2018)

Article Biochemical Research Methods

Lateral fluid flow fractionation using dielectrophoresis (LFFF-DEP) for size-independent, label-free isolation of circulating tumor cells

Waqas Waheed et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

Article Chemistry, Multidisciplinary

Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation

Mengxi Wu et al.

SMALL (2018)

Article Multidisciplinary Sciences

A photoelectrochemical platform for the capture and release of rare single cells

Stephen G. Parker et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

Mette O. Agerbaek et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip

Myoung-Hwan Park et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Multidisciplinary Sciences

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry

Sam H. Au et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells

Fabio Fachin et al.

SCIENTIFIC REPORTS (2017)

Article Nanoscience & Nanotechnology

Highly Efficient Capture and Electrochemical Release of Circulating Tumor Cells by Using Aptamers Modified Gold Nanowire Arrays

Ting-Ting Zhai et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Chemistry, Multidisciplinary

Isolation, Detection, and Antigen-Based Profiling of Circulating Tumor Cells Using a Size-Dictated Immunocapture Chip

Metages Gashaw Ahmed et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemical Research Methods

Circulating tumor cell detection using a parallel flow micro-aperture chip system

Chun-Li Chang et al.

LAB ON A CHIP (2015)

Article Biophysics

Parallel recognition of cancer cells using an addressable array of solid-state micropores

Azhar Ilyas et al.

BIOSENSORS & BIOELECTRONICS (2014)

Article Biochemical Research Methods

Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

Waseem Asghar et al.

LAB ON A CHIP (2012)

Article Nanoscience & Nanotechnology

Electrical detection of cancer biomarker using aptamers with nanogap break-junctions

Azhar Ilyas et al.

NANOTECHNOLOGY (2012)

Article Multidisciplinary Sciences

Isolation of rare circulating tumour cells in cancer patients by microchip technology

Sunitha Nagrath et al.

NATURE (2007)

Review Microbiology

Aptamers come of age - at last

David H. J. Bunka et al.

NATURE REVIEWS MICROBIOLOGY (2006)