4.7 Article

Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Self-Healing Injectable Hydrogels for Tissue Regeneration

Pascal Bertsch et al.

Summary: Biomaterials that can self-heal and maintain their structural integrity have significant advantages in biomedicine. Self-healing injectable hydrogels, a new type of biomaterial, have emerged in the past decade. These hydrogels can temporarily fluidize and then recover their mechanical properties under shear stress. They can be administered locally and minimally invasively, and have moldable properties for personalized medicine. Additionally, they facilitate tissue regeneration through their viscoelastic and diffusive nature. However, challenges remain in balancing self-healing and injectability with physical stability, establishing consensus on rheological characterization, and translating them into therapeutically effective formulations for specific tissues.

CHEMICAL REVIEWS (2023)

Article Materials Science, Biomaterials

3D-printed hydroxyapatite microspheres reinforced PLGA scaffolds for bone regeneration

Jiawei Wei et al.

Summary: This study successfully prepared HA/PLGA three-dimensional porous scaffolds with similar composition to natural bone and strong mechanical strength. By modifying HA microspheres, the scaffolds showed improved composition, structure, mechanical properties, and degradability. In vitro and in vivo experiments demonstrated that the HA/PLGA composite scaffold with 45wt% HA exhibited the best performance in terms of cell compatibility and osteogenic activity. The prepared HA/PLGA composite scaffold with HA microsphere reinforcement has promising application potential in the field of large bone defect repair.

BIOMATERIALS ADVANCES (2022)

Article Dentistry, Oral Surgery & Medicine

The osteogenesis of Ginsenoside Rb1 incorporated silk/micro-nano hydroxyapatite/sodium alginate composite scaffolds for calvarial defect

Yuqiong Wu et al.

Summary: Ginsenoside Rb1 has positive effects on cell viability, proliferation, apoptosis, and osteogenic gene expression, as well as promoting angiogenesis. Micro-nano hydroxyapatite granules combined with silk can serve as an effective delivery system for Ginsenoside Rb1, facilitating bone and blood vessel formation.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2022)

Article Engineering, Environmental

Repair of infected bone defect with Clindamycin-Tetrahedral DNA nanostructure Complex-loaded 3D bioprinted hybrid scaffold

Jun Li et al.

Summary: This study proposes a novel approach combining tetrahedral DNA nanostructure (TDN) with 3D bioprinting to treat infected bone defects. The results demonstrate that a bioprinted scaffold loaded with TDN and antibiotics shows promising efficacy in treating infected bone defects in a rat model. This research has significant implications for the treatment of infected bone defects.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Chemistry, Physical

Photocurable Hydrogel Substrate-Better Potential Substitute on Bone-Marrow-Derived Dendritic Cells Culturing

Jiewen Deng et al.

Summary: Dendritic cells (DCs) are considered the most effective antigen-presenting cells and have therapeutic effects in various diseases. However, conventional culture methods for bone marrow-derived dendritic cells (BMDCs) result in activation and limited immune function. This study developed a novel culture method using a hydrogel substrate, which showed closer resemblance to spleen DCs in terms of molecular expression and better T cell activation and immune response.

MATERIALS (2022)

Article Nanoscience & Nanotechnology

Highly Resilient Dual-Crosslinked Hydrogel Adhesives Based on a Dopamine-Modified Crosslinker

Gi-Yeon Han et al.

Summary: In this study, a dual-crosslinked hydrogel adhesive using TDC as a crosslinker was introduced, demonstrating strong tissue adhesion and high mechanical resilience. Proper wound dressing with this hydrogel accelerated wound healing, indicating potential for advanced polymer synthesis by introducing functional crosslinking agents.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Engineering, Biomedical

Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration

Runze Li et al.

Summary: Injectable hydrogels have attracted attention for bone repair due to their adaptability and minimally invasive nature. A novel injectable self-healing hydrogel system has been developed for enhancing vascularized bone regeneration.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

Free or fixed state of nHAP differentially regulates hBMSC morphology and osteogenesis through the valve role of ITGA7

Fangyuan Bao et al.

Summary: This study investigates the optimal applied form and underlying mechanisms of nano-hydroxyapatite (nHAP) in bone repair. The results suggest that when nHAP is applied in the fixed state in a 3D form, it can induce optimal osteogenesis and increased bone volume through upregulation of the PI3K-AKT signaling pathway and ITGA7-mediated mechanisms, contrary to the results observed with free nHAP.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

A self-healing, magnetic and injectable biopolymer hydrogel generated by dual cross-linking for drug delivery and bone repair

Mengying Chen et al.

Summary: In this study, a self-healing and injectable polysaccharide-based hydrogel was prepared for bone tissue engineering. The composite hydrogel, which incorporated hydroxyapatite and drug-embedded microspheres, exhibited improved mechanical and biological properties, as well as antibacterial effects and drug retardation properties against various pathogens.

ACTA BIOMATERIALIA (2022)

Review Cell & Tissue Engineering

Prospects and challenges of dynamic DNA nanostructures in biomedical applications

Taoran Tian et al.

Summary: DNA nanostructures, with their predictable physicochemical nature, have been widely utilized in various fields, particularly in biomedical applications. These structures possess stimulus-responsive mechanisms that enable their application in basic research, drug delivery, biosensor development, and tissue engineering. However, there are challenges to overcome regarding their clinical translation.

BONE RESEARCH (2022)

Article Engineering, Biomedical

Enhanced bone regeneration via spatiotemporal and controlled delivery of a genetically engineered BMP-2 in a composite Hydrogel

Xin Chen et al.

Summary: The modification strategy using His6-T4L enhances the stability and solubility of BMP-2, allowing for controlled release and maximizing its activity to enhance bone regeneration. Additionally, the gelatin-based hydrogel incorporated with MPs-His6-T4L-BMP2 displays favorable properties for bone defect repair.

BIOMATERIALS (2021)

Review Chemistry, Physical

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Hua Lin et al.

Summary: This article introduces the high-strength polymer hydrogel and its modification methods for bone and cartilage tissue engineering. It discusses the development of hydrogels from weak to high strength and the specific methods to give special physical properties to hydrogels in this field.

MATERIALS (2021)

Article Polymer Science

Preparation of Self-Healable and Spinnable Hydrogel by Dynamic Boronate Ester Bond from Hyperbranched Polyglycerol and Boronic Acid-Containing Polymer

Ho-Sung Yang et al.

Summary: This study presents a method for preparing self-healing hydrogels containing dynamic boronate ester bonds, and investigates the influence of composition on gel formation and self-healing properties. The prepared hydrogel exhibits excellent extensibility and high tensile strength under specific composition.

MACROMOLECULAR RESEARCH (2021)

Article Materials Science, Biomaterials

A novel magnesium ion-incorporating dual-crosslinked hydrogel to improve bone scaffold-mediated osteogenesis and angiogenesis

Xintao Zhang et al.

Summary: A novel hydrogel incorporating magnesium ions was developed to promote cell adhesion, spreading, proliferation, osteogenic differentiation of BMSCs, and angiogenesis, showing potential for repairing bone defects by facilitating cell adhesion, osteogenesis, and vascularization.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Chemistry, Multidisciplinary

Bioswitchable Delivery of microRNA by Framework Nucleic Acids: Application to Bone Regeneration

Songhang Li et al.

Summary: An RNase H-responsive sequence was used to connect a sticky-end tFNA (stFNA) and miR-2861, resulting in a bioswitchable nanocomposite that efficiently unloads and deploys miR-2861 in cells, promoting osteogenic differentiation. This versatile miR delivery strategy also facilitated ideal bone repair via topical injection.

SMALL (2021)

Article Chemistry, Multidisciplinary

Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

Ji-Bong Choi et al.

Summary: The study involved fabricating a composite hydrogel by incorporating BCP into GelMA, resulting in a material with excellent mechanical properties, high cell viability, and strong bone differentiation ability for bone regeneration. The hydrogel also offers advantages for clinical use due to its customizable structure.

NANOMATERIALS (2021)

Article Multidisciplinary Sciences

Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs

Da-Seul Kim et al.

Summary: In this study, a PLGA scaffold combined with magnesium hydroxide and bone extracellular matrix was utilized to enhance anti-inflammation, mechanical properties, and osteoconductivity. Additionally, the development of a bioactive nanocomplex containing polydeoxyribonucleotide and bone morphogenetic protein 2 showed synergistic abilities in angiogenesis and bone regeneration, leading to outstanding performance in anti-inflammation, angiogenesis, and osteogenesis for the PME/NC scaffold. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration.

SCIENCE ADVANCES (2021)

Article Engineering, Biomedical

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

Limei Li et al.

Summary: This study developed nano-hydroxyapatite/resveratrol/chitosan composite microspheres for promoting bone formation and inflammation reduction. The controlled release of resveratrol improved cell adhesion, proliferation, and osteogenic differentiation, leading to enhanced bone regeneration and fracture healing in osteoporotic conditions, indicating promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

BIOACTIVE MATERIALS (2021)

Article Nanoscience & Nanotechnology

Mussel-Inspired Bisphosphonated Injectable Nanocomposite Hydrogels with Adhesive, Self-Healing, and Osteogenic Properties for Bone Regeneration

Bo Wang et al.

Summary: Injectable hydrogels mimicking the natural extracellular matrix have advantages such as microinvasive implantation and complex defect repair, but current options for bone repair lack tissue adhesion, self-healing, and osteogenic activity. A new strategy involving mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties has been developed, showing excellent biocompatibility and promoting cell viability, proliferation, migration, and osteogenesis differentiation. The hydrogels, dually cross-linked, also demonstrate potential for bone regeneration with the successful healing of a rat cranial defect.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Biophysics

A bi-layered membrane with micro-nano bioactive glass for guided bone regeneration

Peiyi Li et al.

Summary: A novel bi-layer membrane was prepared, with a smooth and compact barrier layer made of PLGA, and a rough and porous osteogenic layer consisting of MNBG and PLGA. The study showed that the bi-layered membranes have stable mechanical properties and good histocompatibility, contributing to enhanced bone regeneration activity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Review Pharmacology & Pharmacy

Nano-hydroxyapatite: A Driving Force for Bone Tissue Engineering

M. Prem Blaisie Rajula et al.

Summary: Bone is a nanocomposite tissue made of organic and inorganic elements, with bone grafting being a technique widely used to enhance bone regeneration in dental and orthopedic surgeries. Nanomaterials offer new strategies for bone regeneration due to the drawbacks of traditional treatments, and n-HA has garnered attention for its better bioactivity and bone integration compared to porous HA. This review provides comprehensive insights on the structure, chemical composition, surface modification techniques, and applications of n-HA in bone tissue engineering.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2021)

Review Pharmacology & Pharmacy

Nano-hydroxyapatite use in dentistry: a systematic review

Ioana Roxana Bordea et al.

DRUG METABOLISM REVIEWS (2020)

Article Chemistry, Multidisciplinary

Boronic Ester Based Vitrimers with Enhanced Stability via Internal Boron-Nitrogen Coordination

Xiaoting Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Dentistry, Oral Surgery & Medicine

Titanium mesh for bone augmentation in oral implantology: current application and progress

Yu Xie et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2020)

Article Materials Science, Biomaterials

Hydrogels toughened by biominerals providing energy-dissipative sacrificial bonds

Kazuki Fukao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Article Multidisciplinary Sciences

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Zhong-Kai Cui et al.

NATURE COMMUNICATIONS (2019)

Article Engineering, Biomedical

Fabrication and characterization of a novel collagen-catechol hydrogel

Lian Duan et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2018)

Article Nanoscience & Nanotechnology

Chitosan Lysozyme Conjugates for Enzyme-Triggered Hydrogel Degradation in Tissue Engineering Applications

Soyon Kim et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Materials Science, Biomaterials

High strength and self-healable gelatin/polyacrylamide double network hydrogels

Xiaoqiang Yan et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

Article Biophysics

Ectopic vascularized bone formation by human mesenchymal stem cell microtissues in a biocomposite scaffold

Rajan Narayan et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

Review Chemistry, Multidisciplinary

Self-Healing Hydrogels

Danielle Lynne Taylor et al.

ADVANCED MATERIALS (2016)

Article Nanoscience & Nanotechnology

The preosteoblast response of electrospinning PLGA/PCL nanofibers: effects of biomimetic architecture and collagen I

Yunzhu Qian et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Review Medicine, General & Internal

Osteogenesis imperfecta

Antonella Forlino et al.

LANCET (2016)

Review Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

LANCET (2016)

Review Materials Science, Multidisciplinary

Calcium phosphates in biomedical applications: materials for the future?

Wouter Habraken et al.

MATERIALS TODAY (2016)

Review Engineering, Biomedical

Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review

Ji Hyun Ryu et al.

ACTA BIOMATERIALIA (2015)

Article Chemistry, Multidisciplinary

An Injectable, Self-Healing Hydrogel to Repair the Central Nervous System

Ting-Chen Tseng et al.

ADVANCED MATERIALS (2015)

Review Chemistry, Multidisciplinary

Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering

Huiyuan Wang et al.

ADVANCED MATERIALS (2015)

Article Nanoscience & Nanotechnology

Injectable Dopamine-Modified Poly(ethylene glycol) Nanocomposite Hydrogel with Enhanced Adhesive Property and Bioactivity

Yuan Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

Article Multidisciplinary Sciences

Nanoparticle solutions as adhesives for gels and biological tissues

Severine Rose et al.

NATURE (2014)

Article Multidisciplinary Sciences

A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue

Seung Yun Yang et al.

NATURE COMMUNICATIONS (2013)

Article Pharmacology & Pharmacy

Protocatechuic Aldehyde Protects against Experimental Sepsis In Vitro and In Vivo

Yong Xu et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)

Article Engineering, Biomedical

Ectopic osteochondral formation of biomimetic porous PVA-n-HA/PA6 bilayered scaffold and BMSCs construct in rabbit

Dan Qu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2011)

Review Polymer Science

Polymeric materials for bone and cartilage repair

D. Puppi et al.

PROGRESS IN POLYMER SCIENCE (2010)

Review Materials Science, Multidisciplinary

Preparation of novel bioactive nano-calcium phosphate-hydrogel composites

Judith A. Juhasz et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2010)

Article Cell & Tissue Engineering

Mineralization of Hydrogels for Bone Regeneration

Katerina Gkioni et al.

TISSUE ENGINEERING PART B-REVIEWS (2010)

Review Engineering, Biomedical

Cell Therapy for Bone Regeneration-Bench to Bedside

Kevin Lee et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2009)

Article Engineering, Biomedical

Polylactic acid fibre-reinforced polycaprolactone scaffolds for bone tissue engineering

Vincenzo Guarino et al.

BIOMATERIALS (2008)

Article Biochemistry & Molecular Biology

Novel biomineralization for hydrogels: Electrophoresis approach accelerates hydroxyapatite formation in hydrogels

Junji Watanabe et al.

BIOMACROMOLECULES (2006)

Article Engineering, Biomedical

Bioactivity of ceramic-polymer composites with varied composition and surface topography

SM Rea et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2004)

Article Multidisciplinary Sciences

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

J Street et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)