GCCN: Graph Capsule Convolutional Network for Progressive Mild Cognitive Impairment Prediction and Pathogenesis Identification Based on Imaging Genetic Data

In this study, we proposed a novel method called the graph capsule convolutional network (GCCN) to predict the progression from mild cognitive impairment to dementia and identify its pathogenesis. First, we proposed a novel risk gene discovery component to indirectly target genes with higher interactions with others. These risk genes and brain regions were collected as nodes to construct heterogeneous pathogenic information association graphs. Second, the graph capsules were established by projecting heterogeneous pathogenic information into a set of disentangled latent components. The orientation and length of capsules are representations of the format and intensity of pathogenic information. Third, graph capsule convolution network was used to model the information flows among pathogenic factors and elaborates the convergence of primary capsules to advanced capsules. The advanced capsule is a concept that organizes pathogenic information based on its consistency, and the synergistic effects of advanced capsules directed the development of the disease. Finally, discriminative pathogenic information flows were captured by a straightforward built-in interpretation mechanism, i.e., the dynamic routing mechanism, and applied to the identification of pathogenesis. GCCN has been experimentally shown to be significantly advanced on public datasets. Further experiments have shown that the pathogenic factors identified by GCCN are evidential and closely related to progressive mild cognitive impairment.

Automated summary

In this study, the graph capsule convolutional network (GCCN) method was proposed to predict the progression from mild cognitive impairment to dementia and identify its pathogenesis. The method involved discovering risk genes with higher interactions, constructing heterogeneous pathogenic information association graphs, establishing graph capsules, modeling information flows among pathogenic factors, and capturing discriminative pathogenic information flows through dynamic routing mechanism. GCCN demonstrated significant advancements and identified evidential and closely related pathogenic factors for progressive mild cognitive impairment.