4.8 Article

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Sphingolipids control dermal fibroblast heterogeneity

Laura Capolupo et al.

Summary: Cell-to-cell variations in lipid composition play a crucial role in determining cell states and tissue organization in the human body.

SCIENCE (2022)

Review Biochemistry & Molecular Biology

The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Katharina Huber et al.

Summary: Adapting to changes in nutrient availability and environmental conditions involves coordination between metabolism, growth, and cell cycle regulators. Understanding this coordination is crucial for comprehending various patho-physiological processes.

FEBS JOURNAL (2021)

Article Oncology

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Lindsay A. Broadfield et al.

Summary: The study indicates that high-fat intake can lead to metabolic changes in the liver, including increased glucose uptake and lactate secretion. Furthermore, the research suggests that fat can induce metabolic changes in nontransformed liver cells similar to those found in hepatocellular carcinoma (HCC).

CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

Fotios Sampaziotis et al.

Summary: The study demonstrates the potential of cholangiocyte organoids to repair human biliary epithelium, despite the loss of transcriptional diversity during organoid culture, they remain plastic and have regenerative capabilities.

SCIENCE (2021)

Article Gastroenterology & Hepatology

Steatotic Hepatocytes Release Mature VLDL Through Methionine and Tyrosine Metabolism in a Keap1-Nrf2-Dependent Manner

Akitoshi Sano et al.

Summary: This study found that an imbalance of free amino acids can exacerbate hepatic steatosis by interfering with the oxidative stress sensor system, involving Nrf2 and VLDL-related lipid metabolism. Results suggest that modulation of the Keap1-Nrf2 system can improve liver damage caused by this imbalance.

HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration

Kirstin Meyer et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Review Cell & Tissue Engineering

Epithelial Plasticity during Liver Injury and Regeneration

Victoria L. Gadd et al.

CELL STEM CELL (2020)

Article Multidisciplinary Sciences

Mechano-modulatory synthetic niches for liver organoid derivation

Giovanni Sorrentino et al.

NATURE COMMUNICATIONS (2020)

Review Gastroenterology & Hepatology

Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances

Keisaku Sato et al.

HEPATOLOGY (2019)

Article Cell & Tissue Engineering

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

Xing Deng et al.

CELL STEM CELL (2018)

Review Biochemistry & Molecular Biology

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

David Hojland Ipsen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Article Multidisciplinary Sciences

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Alexander Raven et al.

NATURE (2017)

Article Cell & Tissue Engineering

Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes

Bin Li et al.

STEM CELL REPORTS (2017)

Review Endocrinology & Metabolism

E2F1, a Novel Regulator of Metabolism

Pierre-Damien Denechaud et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis

Pierre-Damien Denechaud et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Cell Biology

RB1: a prototype tumor suppressor and an enigma

Nicholas J. Dyson

GENES & DEVELOPMENT (2016)

Article Multidisciplinary Sciences

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Semir Beyaz et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch et al.

Article Gastroenterology & Hepatology

Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease

Mariana Verdelho Machado et al.

JOURNAL OF HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

NAFLD: A multisystem disease

Christopher D. Byrne et al.

JOURNAL OF HEPATOLOGY (2015)

Article Cell Biology

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Wei-Yu Lu et al.

NATURE CELL BIOLOGY (2015)

Editorial Material Pathology

The Liver Is a Peculiar Organ When It Comes to Stem Cells

George K. Michalopoulos

AMERICAN JOURNAL OF PATHOLOGY (2014)

Review Cell & Tissue Engineering

Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming

Atsushi Miyajima et al.

CELL STEM CELL (2014)

Article Gastroenterology & Hepatology

The Biliary Epithelium Gives Rise to Liver Progenitor Cells

Daniel Rodrigo-Torres et al.

HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

The Portal Inflammatory Infiltrate and Ductular Reaction in Human Nonalcoholic Fatty Liver Disease

Victoria L. Gadd et al.

HEPATOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Cell Biology

The multiple connections between pRB and cell metabolism

Brandon N. Nicolay et al.

CURRENT OPINION IN CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch et al.

NATURE (2013)

Article Gastroenterology & Hepatology

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

Regina Espanol-Suner et al.

GASTROENTEROLOGY (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Anatomy & Morphology

Facultative Stem Cells in Liver and Pancreas: Fact and Fancy

Kilangsungla Yanger et al.

DEVELOPMENTAL DYNAMICS (2011)

Article Cell Biology

E2F transcription factor-1 regulates oxidative metabolism

Emilie Blanchet et al.

NATURE CELL BIOLOGY (2011)

Article Developmental Biology

Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver

Mayuko Okabe et al.

DEVELOPMENT (2009)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Regulation of the PDK4 isozyme by the Rb-E2F1 complex

Michael C. F. Hsieh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Computer Science, Interdisciplinary Applications

FactoMineR: An R package for multivariate analysis

Sebastien Le et al.

JOURNAL OF STATISTICAL SOFTWARE (2008)

Article Medicine, Research & Experimental

Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes

Andrea De Gottardi et al.

LABORATORY INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

H Malhi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Gastroenterology & Hepatology

A clinical-morphological study on cholestatic presentation of nonalcoholic fatty liver disease

P Sorrentino et al.

DIGESTIVE DISEASES AND SCIENCES (2005)

Review Biochemistry & Molecular Biology

The E2F transcriptional network: old acquaintances with new faces

DK Dimova et al.

ONCOGENE (2005)