4.8 Article

Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function

Masum M. Mia et al.

Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.

CARDIOVASCULAR RESEARCH (2022)

Review Cell Biology

New Insights into Hippo/YAP Signaling in Fibrotic Diseases

Masum M. Mia et al.

Summary: Fibrosis is a defective wound healing process often seen after chronic injury and/or inflammation in various organs. The Hippo signaling pathway plays a crucial role in the pathophysiology of fibrotic diseases, regulating cell proliferation, apoptosis, cell fate decisions, and contributing to the development of organ fibrosis.

CELLS (2022)

Article Biochemistry & Molecular Biology

Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice

Elizabeth F. Redente et al.

Summary: A simplified repetitive bleomycin instillation strategy was developed to mimic persistent and progressive pulmonary fibrosis, recapitulating histological and radiographic characteristics of idiopathic pulmonary fibrosis (IPF). Compared to the single bleomycin instillation model, this simplified repetitive model may be better suited for addressing mechanistic questions about IPF pathogenesis and preclinical studies of antifibrotic drug candidates.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload

Dan Shao et al.

Summary: The study revealed that Lats2 plays a crucial role in the heart in response to stress, promoting cardiomyocyte apoptosis through a p53-dependent mechanism. Lats2+/- mice showed attenuation of cardiac hypertrophy and dysfunction induced by TAC, with suppressed apoptosis.

SCIENTIFIC REPORTS (2021)

Article Physiology

Expression of serum response factor in the lung mesenchyme is essential for development of pulmonary fibrosis

Ksenija Bernau et al.

Summary: The study demonstrates the critical role of SRF in myofibroblast expansion in lung mesenchyme during bleomycin-induced pulmonary fibrosis. This sets the stage for pharmacological strategies that specifically target SRF in the lung mesenchyme as a potential means of treating pulmonary fibrosis.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

Article Cell & Tissue Engineering

Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

Ian J. Penkala et al.

Summary: The regeneration of the architecturally complex alveolar niche of the lung requires precise temporal and spatial control of epithelial cell behavior. Injury can result in a permanent reduction in gas exchange surface area and respiratory function. The plasticity of alveolar type 1 cells plays a crucial role in driving regeneration, particularly in the early postnatal period.

CELL STEM CELL (2021)

Article Multidisciplinary Sciences

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo

Danielle R. Little et al.

Summary: Differential chromatin binding of NKX2-1 determines opposing alveolar cell fates in the murine lung, with loss of YAP/TAZ directing NKX2-1 to alternative binding sites leading to cell fate conversion.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation

Maryam Sharifi-Sanjani et al.

Summary: The study indicates that Yap is elevated in LV tissue of HF patients, associated with down-regulation of its upstream inhibitor LATS1 and upregulation of the fibrosis marker CTGF. In vitro application of profibrotic stress to human cardiac fibroblasts increased Yap levels, promoted cell proliferation and collagen I production, and altered mTOR pathway activity, suggesting a potential role of Yap in LV remodeling in HF.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1

Jason J. Gokey et al.

Summary: YAP activation promotes proliferation of alveolar epithelial cells and increases AT1 cell numbers, while YAP deletion leads to increased expression of genes associated with mature AT2 cells. YAP collaborates with other key factors to regulate alveolar epithelial cell differentiation.

ISCIENCE (2021)

Letter Critical Care Medicine

Ineffectual Type 2-to-Type 1 Alveolar Epithelial Cell Differentiation in Idiopathic Pulmonary Fibrosis: Persistence of the KRT8hi Transitional State

Peng Jiang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Jamie Francisco et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

Article Ophthalmology

ZEB1 Mediates Fibrosis in Corneal Endothelial Mesenchymal Transition Through SP1 and SP3

JeongGoo Lee et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

Article Multidisciplinary Sciences

PU.1 controls fibroblast polarization and tissue fibrosis

Thomas Wohlfahrt et al.

NATURE (2019)

Article Medicine, Research & Experimental

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation

Ryan LaCanna et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Cell Biology

Role of the Hippo Pathway in Fibrosis and Cancer

Cho-Long Kim et al.

CELLS (2019)

Article Medicine, Research & Experimental

Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis

Shigeyuki Shichino et al.

JCI INSIGHT (2019)

Article Medicine, Research & Experimental

TAZ is required for lung alveolar epithelial cell differentiation after injury

Tianhe Sun et al.

JCI INSIGHT (2019)

Article Urology & Nephrology

Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis

Ming Liang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Multidisciplinary Sciences

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

Katherine Martin et al.

NATURE COMMUNICATIONS (2016)

Article Respiratory System

The genetic basis of idiopathic pulmonary fibrosis

Jonathan A. Kropski et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Cell Biology

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

Toshiro Moroishi et al.

GENES & DEVELOPMENT (2015)

Article Gastroenterology & Hepatology

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Inge Mannaerts et al.

JOURNAL OF HEPATOLOGY (2015)

Article Cell Biology

Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis

Christina E. Barkauskas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Tumor Necrosis Factor-α Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages

Elizabeth F. Redente et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Review Pharmacology & Pharmacy

The epithelium in idiopathic pulmonary fibrosis: breaking the barrier

Ana Camelo et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Medicine, Research & Experimental

Molecular Mechanisms in Progressive Idiopathic Pulmonary Fibrosis

Mark P. Steele et al.

ANNUAL REVIEW OF MEDICINE, VOL 64 (2013)

Article Multidisciplinary Sciences

Hippo pathway effector Yap promotes cardiac regeneration

Mei Xin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Medicine, Research & Experimental

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

Harold A. Chapman et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Medicine, General & Internal

Idiopathic pulmonary fibrosis

Talmadge E. King et al.

LANCET (2011)

Article Biochemistry & Molecular Biology

Antifibrotic effect via the regulation of transcription factor Sp1 in lung fibrosis

Yoon-Seup Kum et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Review Medicine, Research & Experimental

Mechanisms of pulmonary fibrosis

VJ Thannickal et al.

ANNUAL REVIEW OF MEDICINE (2004)