4.5 Article

Asymmetric Hydrogenation of Imines Using NHC-Phosphine Iridium Complexes

Journal

ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 12, Issue 6, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202300173

Keywords

Asymmetric Hydrogenation; chiral amines; N-heterocyclic carbene; Imines; Iridium

Ask authors/readers for more resources

This article describes a method for synthesizing highly enantioselective alpha-chiral amine compounds using NHC, P-iridium complexes catalyzed asymmetric hydrogenation of imines. The hydrogenation proceeds smoothly, even under hydrogen pressure. Experimental results indicate that the reduction process most likely progresses through a combination of direct hydrogenation and a hydrogen transfer process using either H-2 or iPrOH as the reductant, respectively.
alpha-Chiral amines represent a frequently observed functional group in pharmaceuticals. Here, the synthesis of such motifs (up to 91% ee) is described by asymmetric hydrogenation of imines catalyzed by NHC,P-iridium complexes. The hydrogenation proceeded smoothly, even under balloon pressure of hydrogen atmosphere. Mechanistic experiments indicated that the reduction most likely advances by a combination of direct hydrogenation and a hydrogen transfer process using either H-2 or iPrOH as the reductant, respectively.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available