Exploration of effective biomarkers and infiltrating Immune cells in Osteoarthritis based on bioinformatics analysis

Article Immunology

Circ_0016347 modulates proliferation, migration, invasion, cell cycle, and apoptosis of osteosarcoma cells via the miR-661/IL6R axis

Yan Liu et al.

Summary: This study found that circ_0016347 is overexpressed in osteosarcoma and functions as an oncogene through the miR-661/IL6R axis and JAK2/STAT3 signaling pathway.

AUTOIMMUNITY (2022)

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Review Engineering, Biomedical

The immune microenvironment in cartilage injury and repair

Muzhe Li et al.

Summary: The limited ability of articular cartilage to repair itself is hindered by inflammatory problems. Immune response plays a crucial role in both promoting cartilage repair and accelerating cartilage degradation. Multi-dimensional regulation of the inflammatory microenvironment is needed for cartilage regeneration.

ACTA BIOMATERIALIA (2022)

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Article Pharmacology & Pharmacy

Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction via AKT/GSK3β/FYN-Mediated NRF2 Activation

Yue Xuan et al.

Summary: The study showed that RES alleviated osteoblast dysfunction induced by high glucose by activating NRF2 to suppress oxidative stress. Additionally, NRF2 activation via RES was regulated by the AKT/GSK3 beta/FYN axis, as identified through experiments using Nrf2-shRNA and wortmannin.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cell & Tissue Engineering

Exosomal miR-150 derived from BMSCs inhibits TNF-α-mediated osteoblast apoptosis in osteonecrosis of the femoral head by GREM1/NF-κB signaling

Li-Wen Zheng et al.

Summary: This study aimed to investigate the functions of exosomal miR-150 derived from bone marrow mesenchymal stem cells in osteonecrosis of the femoral head (ONFH). The findings showed that exosomal miR-150 inhibited osteoblast apoptosis, promoted osteogenic differentiation and autophagy, and improved the pathological features of ONFH by regulating the GREM1/NF-kappa B axis.

REGENERATIVE MEDICINE (2022)

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Review Immunology

Obesity, Inflammation, and Immune System in Osteoarthritis

Udhaya Nedunchezhiyan et al.

Summary: Obesity is the most important risk factor for the development and progression of osteoarthritis, and it was previously believed to be caused by excessive weight leading to joint overloading and cartilage destruction. However, recent studies have identified other factors such as adipose deposition, insulin resistance, and the improper coordination of innate and adaptive immune responses that contribute to obesity-associated osteoarthritis. Multiple inflammatory cells are recruited into the synovial joint and play an important role in pathological changes. Macrophage polarization and mediators produced by macrophages have been extensively studied and linked to the inflammatory and destructive responses in the synovium and cartilage. The role of other innate immune cells and adaptive immune cells in the pathogenesis of osteoarthritis is still under exploration.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3β/Fyn-dependent Nrf2 activation

Doudou Dong et al.

Summary: Alpinetin can inhibit macrophage infiltration and alleviate atherosclerosis by improving the redox homeostasis.

FASEB JOURNAL (2022)

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Article Orthopedics

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Xiaobin Huang et al.

Summary: The study suggests that DKK1 and FRZB are negatively correlated with the severity of osteoarthritis (OA) and multiple proinflammatory cytokines, indicating their potential as joint disease-specific biomarkers.

CARTILAGE (2021)

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Article Rheumatology

Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression

Ming-Feng Hsueh et al.

Summary: The study evaluated the role of immune cells and cytokines in the pathogenesis and progression of knee osteoarthritis. The results showed that concentrations of elastase and TGF-beta 1 in SF were associated with the severity of OA progression, indicating their predictive potential for disease progression.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Endocrinology & Metabolism

Cartilage tissue miR-214-3p regulates the TrkB/ShcB pathway paracrine VEGF to promote endothelial cell migration and angiogenesis

Peng Xiao et al.

Summary: The study revealed that chondrocytes miR-214-3p regulates endothelial cell migration and angiogenesis by targeting TrkB, influencing the development of osteoarthritis.

BONE (2021)

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Article Immunology

Circ_SPG11 plays contributing effects on IL-1β-induced chondrocyte apoptosis and ECM degradation via miR-665 inhibition-mediated GREM1 upregulation

Xiao Ouyang et al.

Summary: The dysregulation of circular RNA circ_SPG11 has been observed in osteoarthritis cartilage and IL-1 beta-treated chondrocytes, with knockdown of circ_SPG11 showing potential in restoring cell proliferation and reducing cell apoptosis and ECM degradation. Circ_SPG11 interacts with miR-665 to negatively regulate its expression, and miR-665 inhibition can reverse the inhibitory effect on chondrocyte injury caused by circ_SPG11 knockdown, suggesting a potential mechanism for OA progression.

CLINICAL IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis

Ying Song et al.

Summary: The study reveals that FOXO3a suppresses breast cancer metastasis by regulating miR-29b-2 and miR-338 to inhibit VEGF-A/NRP1 signaling pathway. This finding proposes a novel therapeutic target for breast cancer treatment.

ONCOGENE (2021)

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Review Rheumatology

Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis

Murad Alahdal et al.

Summary: Dendritic cells have been found to play a potential role in the pathogenesis of osteoarthritis, with studies showing increased expression of toll-like receptors and secretion of inflammatory cytokines by DCs derived from OA patients. Strategies involving tolerogenic plasmacytoid DCs injections are suggested for treating OA inflammations.

RHEUMATOLOGY (2021)

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Article Immunology

Crosstalk between immune cells and bone cells or chondrocytes

Zhiqin Deng et al.

Summary: Osteoimmunology studies the interactions between the immune system and the skeletal system, with different immune cells playing various roles in regulating osteoclasts and chondrocytes. These cells maintain a dynamic balance through multiple signaling mechanisms.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Medicine, General & Internal

Diagnosis and Treatment of Hip and Knee Osteoarthritis A Review

Jeffrey N. Katz et al.

Summary: Osteoarthritis is a prevalent joint disease that can impact various joints, with risk factors including age, gender, obesity, genetics, and major joint injury. Treatment typically involves exercise, weight management, education, and medication therapy. Advanced cases may require surgical intervention for pain relief and improved function.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Orthopedics

Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for Osteoarthritis

M. N. Ferrao Blanco et al.

Summary: Osteoarthritis (OA) is a major global health issue characterized by joint pain and inflammation. Tyrosine kinases have been associated with chondrocyte hypertrophy, highlighting their potential as therapeutic targets for OA.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Article Orthopedics

Perivascular lymphocytic aggregates in hip prosthesis-associated adverse local tissue reactions demonstrate Th1 and Th2 activity and exhausted CD8+ cell responses

Felipe Eltit et al.

Summary: In patients undergoing hip implants, adverse local tissue reactions (ALTRs) can occur, especially with metal-on-metal and metal-on-polyethylene prosthetics. Among these reactions, those dominated by lymphocytes show similar immune-related transcript profiles and cell signatures between MoM and MoP prosthetics, suggesting a common hypersensitivity pathogenesis in these cases.

JOURNAL OF ORTHOPAEDIC RESEARCH (2021)

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Article Orthopedics

Identifying hub genes and immune infiltration of osteoarthritis using comprehensive bioinformatics analysis

Zheng-yuan Wu et al.

Summary: Through bioinformatics analysis, 18 hub DEGs related to OA were identified, primarily involved in the PI3K-Akt signaling pathway and Rap1 signaling pathway. Additionally, immune infiltration analysis revealed differences in immune infiltration between patients with OA and healthy controls, with the hub gene ZNF160 closely related to immune cells, especially mast cell activation in OA.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Cell Biology

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

Zhongyang Lv et al.

Summary: The study demonstrates that TRPV1 inhibits M1 macrophage polarization in synovium, thereby reducing synovitis and attenuating the progression of osteoarthritis.

CELL DEATH & DISEASE (2021)

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Article Immunology

Therapeutic effect and potential mechanisms of intra-articular injections of miR-140-5p on early-stage osteoarthritis in rats

Fei Cao et al.

Summary: MicroRNAs have received significant attention in recent years for their potential role in osteoarthritis pathogenesis. A study on rats showed that intra-articular injections of miR-140-5p can effectively alleviate early-stage OA progression by modulating various biological processes and pathways. In particular, multiple injections of miR-140-5p demonstrated better therapeutic effects compared to single injections in alleviating early-stage OA.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Cell Biology

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway

Yuheng Lu et al.

Summary: MFG-E8 plays a crucial role in chondrocyte senescence and macrophage polarization during osteoarthritis, with its loss leading to progressive articular cartilage damage and osteophyte formation. Injection of MFG-E8 can alleviate these effects, while miR-99b-5p inhibits MFG-E8 and exacerbates experimental OA.

CELL DEATH & DISEASE (2021)

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Review Biochemistry & Molecular Biology

Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis

Vilim Molnar et al.

Summary: Osteoarthritis is a common cause of disability worldwide, affecting all joint tissues equally. The pathogenesis involves low-grade inflammation leading to an imbalance between anabolic and catabolic processes. The complex network of cytokines regulating these processes plays a central role in the development and progression of osteoarthritis, with concentrations of proinflammatory and anti-inflammatory cytokines varying based on disease stage and activity levels.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Rheumatology

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

Jiansen Lu et al.

Summary: Fargesin switches macrophage phenotypes from M1 to M2 subtypes and prevents cartilage degeneration by downregulating p38/ERK MAPK and p65/NF-kappa B signaling pathways. Targeting macrophage reprogramming or inhibiting the crosstalk between macrophages and chondrocytes in early OA may be an effective preventative strategy.

ARTHRITIS RESEARCH & THERAPY (2021)

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Article Rheumatology

Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis

Mukundan Attur et al.

Summary: Postn deficiency was found to significantly reduce cartilage degeneration and synovitis in both post-traumatic and age-related models of OA in mice, as well as result in lower trabecular bone parameters. Additionally, RNA-seq analysis revealed differences in gene expression related to cell adhesion, differentiation, cell cycle, and DNA repair between Postn(-/-) and wild-type mice, suggesting a potential mechanistic role of Postn in OA.

ARTHRITIS RESEARCH & THERAPY (2021)

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Article Rheumatology

Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis

Nils Rosshirt et al.

Summary: Early OA joints exhibit significant inflammation characterized by infiltration of CD4(+) T cells, with a predominant Th1 cell polarization. Inflammation appears to be driven by direct proinflammatory cell interaction, with cytokine signaling being negligible at the site of inflammation in early OA, except for a significant increase in IL-6 in synovial fluid compared to peripheral blood.

ARTHRITIS RESEARCH & THERAPY (2021)

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Article Orthopedics

Role of Inflammation and the Immune System in the Progression of Osteoarthritis

Jennifer E. Woodell-May et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

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Article Orthopedics

Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization

O. R. Mahon et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

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Article Orthopedics

Macrophages regulate the progression of osteoarthritis

H. Zhang et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

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MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

Yueh-Shan Weng et al.

MOLECULAR CANCER (2019)

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Article Multidisciplinary Sciences

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Stephan Culemann et al.

NATURE (2019)

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Article Cardiac & Cardiovascular Systems

Antiangiogenic VEGF165b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease

Vijay Chaitanya Ganta et al.

CIRCULATION (2019)

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Article Medicine, Research & Experimental

Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients

Matthew J. Wood et al.

JCI INSIGHT (2019)

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Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface

Rongcai Lin et al.

THERANOSTICS (2019)

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Article Biochemistry & Molecular Biology

Inflammatory milieu cultivated Sema3A signaling promotes chondrocyte apoptosis in knee osteoarthritis

Jie Sun et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

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Implications of Angiogenesis Involvement in Arthritis

Iona J. MacDonald et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress

Chikako Sumi et al.

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ImmPort, toward repurposing of open access immunological assay data for translational and clinical research

Sanchita Bhattacharya et al.

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Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L. G. James et al.

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Dvir Aran et al.

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Id2 regulates hyporesponsive invariant natural killer T cells

Martin H. Stradner et al.

IMMUNOLOGY AND CELL BIOLOGY (2016)

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VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation

Nougboli A. E. Oussa et al.

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Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis

Jun Yi et al.

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From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells

Cristina Manferdini et al.

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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Alexander Lex et al.

IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS (2014)

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Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation

Dirk Woetzel et al.

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Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix

Tonia L. Vincent

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Semaphorin 3A Is Expressed in Human Osteoarthritic Cartilage and Antagonizes Vascular Endothelial Growth Factor 165-Promoted Chondrocyte Migration An Implication for Chondrocyte Cloning

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Exploration of effective biomarkers and infiltrating Immune cells in Osteoarthritis based on bioinformatics analysis

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