Journal
LAB ON A CHIP
Volume 16, Issue 23, Pages 4601-4611Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6lc01065b
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Funding
- New Faculty Startup Funds from Texas Tech University
- Cancer Prevention Research Institute of Texas (CPRIT) [RP150720]
- CPRIT
- National Natural Science Foundation of China [81370417]
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Capillary flow layer-by-layer (CF-LbL) is a microfluidic platform for high throughput preparation and screening of nanolayered polymer films. Using a simple benchtop version of CF-LbL, we systematically studied the effects of various flow conditions and channel geometries on the thickness and surface roughness of the resulting films. We also investigated the biocompatibility and degradation behaviors of a series of enzymatically-degradable films made from naturally derived polymers, i. e. either alginate or hyaluronic acid as the anionic species and poly-L-arginine as the positive species. Furthermore, using one optimized film formulation for coating on the inside walls of a microfluidic chip, we successfully demonstrated the ability of this film to capture and rapidly release cancer cells from whole blood. This simple platform is expected to be a powerful tool to increase the accessibility of the LbL film assembly to a broader scientific community.
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