Journal
LAB ON A CHIP
Volume 16, Issue 9, Pages 1544-1548Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6lc00183a
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Funding
- National Institute of Environmental Health Sciences of the NIH [R01ES022190]
- Department of Energy's Office of Biological and Environmental Research
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Characterizing protein-ligand binding dynamics is crucial for understanding protein function and for developing new therapeutic agents. We present a novel microfluidic platform that features rapid mixing of protein and ligand solutions, variable incubation times, and an integrated electrospray ionization source for mass spectrometry-based monitoring of protein-ligand binding dynamics. This platform offers many advantages, including solution-based binding, label-free detection, automated operation, rapid mixing, and low sample consumption.
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