4.6 Article

Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Advances in Acute Ischemic Stroke Therapy

Yunyun Xiong et al.

Summary: The treatment of acute ischemic stroke is advancing with intravenous thrombolysis, mechanical thrombectomy, and cytoprotection being investigated. Later treatment with alteplase and the use of tenecteplase are beneficial alternatives to alteplase. Cytoprotection as an adjunct to reperfusion has shown no efficacy in prior clinical trials, but may have potential benefits.

CIRCULATION RESEARCH (2022)

Review Endocrinology & Metabolism

pH and proton-sensitive receptors in brain ischemia

Xiang-ming Zha et al.

Summary: In disease conditions such as brain ischemia, the mammalian brain expresses various proton receptors to respond to the increase in extracellular proton concentration. These receptors play important roles in regulating ion flow and neuronal injury.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

Article Clinical Neurology

Impaired cerebrovascular reactivity is associated with recurrent stroke in patients with severe intracranial arterial stenosis: A C02 BOLD fMRI study

Jeremie Papassin et al.

Summary: This study found that impaired cerebrovascular reactivity is associated with an increased risk of recurrent stroke in patients with symptomatic SIAS. The measurement of CVRMCA can be used as a well-tolerated method to select higher-risk patients for further therapeutic trials.

JOURNAL OF NEURORADIOLOGY (2021)

Review Endocrinology & Metabolism

Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning

Chun-Yan Li et al.

Summary: Ischemic postconditioning (PostC) can reduce cerebral ischemia/reperfusion (I/R) injury through protective mechanisms, with in situ ischemic postconditioning (ISPostC) and remote ischemic postconditioning (RIPostC) acting through different cell signaling pathways. Studies have shown that both ISPostC and RIPostC can decrease brain ischemic injury through various protective mechanisms.

METABOLIC BRAIN DISEASE (2021)

Article Biotechnology & Applied Microbiology

Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis

Stefano Raffaele et al.

Summary: The activation of microglia and monocyte-derived macrophages affects the regenerative process of oligodendrocyte precursor cells (OPCs), promoting functional recovery after stroke. Regenerative microglia-derived extracellular vesicles (EVs) can restore protective immune cell functions, limit senescence, and enhance OPC maturation, potentially leading to improved neurological functionality in post-stroke phase. Tumor necrosis factor carried by EVs mediates pro-differentiating effects on OPCs, suggesting implications for regenerative therapies.

MOLECULAR THERAPY (2021)

Review Clinical Neurology

Neuroprotection by Remote Ischemic Conditioning in Rodent Models of Focal Ischemia: a Systematic Review and Meta-Analysis

Allyson J. Ripley et al.

Summary: Remote ischemic conditioning (RIC) shows promise in reducing infarct volume in ischemic stroke, especially in males and when delivered poststroke. However, there is a high risk of bias and poor methodological reporting in many studies, potentially exaggerating efficacy. Important but under-investigated topics include the efficacy of RIC in different stroke models, varied infarct sizes and locations, and potential sex differences.

TRANSLATIONAL STROKE RESEARCH (2021)

Review Neurosciences

Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia

Lu Lian et al.

Summary: Ischemic stroke is a common cause of death and disability globally, and neuroinflammation plays a significant role in the process. MicroRNAs may have regulatory effects on microglia-associated inflammation, making them potential therapeutic targets for improving stroke outcomes and modulating neuroinflammation.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Neurosciences

Acid-base balance and cerebrovascular regulation

Hannah G. Caldwell et al.

Summary: Regulation and defense of intracellular pH are crucial for homeostasis, affecting cerebral blood flow which is essential for human health and disease. Understanding the relationships between CBF, PCO2, HCO3-, and pH may provide insights to improve CBF regulation in clinical practice for treatment of systemic acid-base disorders.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

Article Neurosciences

Delayed Exercise-induced Upregulation of Angiogenic Proteins and Recovery of Motor Function after Photothrombotic Stroke in Mice

Abdullah Al Shoyaib et al.

Summary: This study found that delayed physical rehabilitation with overnight voluntary wheel running can aid in the recovery of motor function in mice post-stroke, and is correlated with angiogenic potential in the brain.

NEUROSCIENCE (2021)

Review Biochemistry & Molecular Biology

Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?

Nicolas Hugues et al.

Summary: Stroke-induced cognitive impairments can be improved by high-intensity interval training (HIIT) which enhances neuroplasticity processes and cognitive functions. However, there are methodological limitations in studies on exercise recommendations for stroke patients. The potential of HIIT in promoting neurotrophic factors expression, neurogenesis, and synaptic plasticity in stroke rehabilitation is significant.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Clinical Neurology

Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms

Zidan Zhao et al.

Summary: This study showed that low oxygen post-conditioning (LOPC) may improve cognition in mice after experimental stroke. LOPC not only enhanced learning and memory, but also reduced neuronal loss, restored vascular deficits, and decreased the severity of amyloid-beta (Aß) burden in the brain. These findings provide further insight into the cognitive benefits of LOPC post-stroke.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

Remote Ischemic Conditioning and Stroke Recovery

Matthew W. McDonald et al.

Summary: Remote ischemic conditioning (RIC) shows neuroprotective effects in stroke patients by inducing ischemia at specific time points, but fails to enhance post-stroke behavioral recovery in the later acute phase.

NEUROREHABILITATION AND NEURAL REPAIR (2021)

Article Multidisciplinary Sciences

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Jan Wenzel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Clinical Neurology

GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia

Tao Wang et al.

STROKE (2020)

Article Multidisciplinary Sciences

The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model

Koichi Sato et al.

SCIENTIFIC REPORTS (2020)

Review Neurosciences

Neural stem cell therapies and hypoxic-ischemic brain injury

Lei Huang et al.

PROGRESS IN NEUROBIOLOGY (2019)

Article Clinical Neurology

Low Oxygen Post Conditioning as an Efficient Non-pharmacological Strategy to Promote Motor Function After Stroke

Giovanni Pietrogrande et al.

TRANSLATIONAL STROKE RESEARCH (2019)

Article Neurosciences

Opening a New Time Window for Treatment of Stroke by Targeting HDAC2

Yu-Hui Lin et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Postconditioning-induced neuroprotection, mechanisms and applications in cerebral ischemia

Yan-Ying Fan et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

Article Neurosciences

Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear

Lauren Larke Vollmer et al.

BIOLOGICAL PSYCHIATRY (2016)

Article Cell Biology

Neurogenesis following Stroke Affecting the Adult Brain

Olle Lindvall et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Clinical Neurology

5% CO2 inhalation suppresses hyperventilation-induced absence seizures in children

Xiao-Fan Yang et al.

EPILEPSY RESEARCH (2014)

Article Endocrinology & Metabolism

A novel neuroprotective strategy for ischemic stroke: transient mild acidosis treatment by CO2 inhalation at reperfusion

Yan-Ying Fan et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Article Endocrinology & Metabolism

Post ischemia intermittent hypoxia induces hippocampal neurogenesis and synaptic alterations and alleviates long-term memory impairment

Yi-Wei Tsai et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

Article Multidisciplinary Sciences

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex

Anna Letizia Allegra Mascaro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Clinical Neurology

Hurdles to Clear Before Clinical Translation of Ischemic Postconditioning Against Stroke

Heng Zhao

TRANSLATIONAL STROKE RESEARCH (2013)

Article Pharmacology & Pharmacy

Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro

Yoshiko Onozawa et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Article Neurosciences

Genomic Analysis of Reactive Astrogliosis

Jennifer L. Zamanian et al.

JOURNAL OF NEUROSCIENCE (2012)

Review Clinical Neurology

Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation

Marcela Pekna et al.

STROKE (2012)

Article Medicine, General & Internal

Stroke Care 2 Stroke rehabilitation

Peter Langhorne et al.

LANCET (2011)

Article Biochemistry & Molecular Biology

Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain

Jennifer McGuire et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Review Neurosciences

Astrocyte metabolism and signaling during brain ischemia

David J. Rossi et al.

NATURE NEUROSCIENCE (2007)

Article Endocrinology & Metabolism

Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats

Heng Zhao et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2006)

Review Neurosciences

Glial inhibition of CNS axon regeneration

Glenn Yiu et al.

NATURE REVIEWS NEUROSCIENCE (2006)