2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform

The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33-65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.

Automated summary

The aim of this study was to create a new scaffolding system for the controlled release of curcumin. The scaffolds were composed of 2-hydroxyethyl methacrylate, gelatin, alginate, and titanium(IV) oxide nanoparticles. The hybrid scaffolds showed favorable properties such as high porosity, swelling capacity, hydrophilicity, degradation rate, curcumin loading efficiency, and controlled release profiles. The cytotoxicity test results indicated satisfactory cell growth on the hybrid scaffold surfaces. These hybrid scaffolds have potential for further in vivo and clinical studies.