Recent Advances in Centrifugal Spinning and Their Applications in Tissue Engineering

Over the last decade, researchers have investigated the potential of nano and microfiber scaffolds to promote wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique is favored over others due to its relatively straightforward mechanism for producing large quantities of fiber. Many polymeric materials have yet to be investigated in search of those with multifunctional properties that would make them attractive in tissue applications. This literature presents the fundamental process of fiber generation, and the effects of fabrication parameters (machine, solution) on the morphologies such as fiber diameter, distribution, alignment, porous features, and mechanical properties. Additionally, a brief discussion is presented on the underlying physics of beaded morphology and continuous fiber formation. Consequently, the study provides an overview of the current advancements in centrifugally spun polymeric fiber-based materials and their morphological features, performance, and characteristics for tissue engineering applications.

Automated summary

In the past decade, researchers have explored the potential of nano and microfiber scaffolds in wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique has gained popularity for its ability to produce large quantities of fiber in a straightforward manner. This literature review discusses the process of fiber generation, the effects of fabrication parameters on fiber morphology, and provides an overview of the advancements in centrifugally spun polymeric fiber-based materials for tissue engineering applications.