Synthesis of Phospholane-Phosphoramidite Ligands and their Application in Asymmetric Catalysis

A set of phospholane-phosphoramidite ligands, which possess four elements of chirality, has been synthesized through a modular diastereoselective process. The ligands were applied in the Rh-catalyzed asymmetric CC hydrogenation of several functionalized olefins with enantioselectivities of up to 99%ee and a turnover frequency of up to 12000h(-1), in the Rh-catalyzed hydroformylation of vinyl arenes with enantioselectivities of up to 79%ee, and in the Ir-catalyzed asymmetric CN hydrogenation of different aryl imines with enantioselectivities of up to 79%ee.