Journal
POLYMERS
Volume 15, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/polym15102302
Keywords
emulsion gels; delivery systems; drug delivery; topical formulations
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Novel delivery systems such as emulgels play an important role in incorporating and protecting active substances for cosmetics, drugs, and food ingredients. The selection of main constituents determines the stability and efficacy of emulgels, which are dual-controlled release systems. Emulsifiers and gelling agents are crucial in ensuring emulsion stability and improving sensory properties.
Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies.
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