A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait (vol 18, e1009398, 2022)

Summary: In this study, a musculoskeletal finite element model of a rat knee joint was used to evaluate cartilage biomechanical responses during a gait cycle. The results showed that simulating anatomical and locomotion characteristics accurately estimated tissue responses such as contact pressures, stresses, strains, and fluid pressures. This approach is important for investigating the effects of gait abnormalities on the adaptation and degeneration of rat knee joint tissues and could contribute to understanding the biomechanically-driven mechanisms of osteoarthritis progression as a consequence of joint injury or obesity.