Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications

Review Pharmacology & Pharmacy

Programming inflammatory cell death for therapy

Shelbi Christgen et al.

Summary: Programmed cell death (PCD) is crucial for organism development and host defense, but dysregulation can lead to diseases. Modulating cell death has therapeutic potential, and targeting upstream sensors and signaling molecules is important. Multiple PCD pathways are regulated by these molecules and offer potential for therapeutic intervention.

PHARMACOLOGY & THERAPEUTICS (2022)

Add to Collection

Review Immunology

PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality

Nagakannan Pandian et al.

Summary: Innate immunity is the initial response to pathogens and cellular insults, with pattern recognition receptors sensing specific molecular patterns and inducing an innate immune response. Recent research has discovered a unique form of inflammatory cell death, PANoptosis, which is regulated by assembled complexes called PANoptosomes. Understanding innate immune cell death and PANoptosis is crucial for developing effective treatment strategies.

JOURNAL OF IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki et al.

Summary: The combination of TNF-alpha and IFN-gamma induces inflammatory cell death characterized by PANoptosis, which can be inhibited to protect mice from the pathological effects and death caused by COVID-19. Blocking the cytokine-mediated inflammatory cell death signaling pathway may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.

CELL (2021)

Add to Collection

Article Multidisciplinary Sciences