Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels

Article Pharmacology & Pharmacy

Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol

Erika K. Harding et al.

Summary: Cannabinoids are a potential therapy for chronic pain, but their analgesic efficacy is often not reported in clinical trials. This study found that cannabinoids can produce analgesia by inhibiting voltage gate calcium channels, and different cannabinoids target different types of channels through distinct mechanisms. The cannabinoid CBD binds to and occludes the pore of the Ca(v)3.2 channel, alleviating inflammatory and neuropathic pain.

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Review Neurosciences

Central and peripheral contributions of T-type calcium channels in pain

Erika K. Harding et al.

Summary: This article reviews the contribution of T-type calcium channels to neuronal excitability and function in different neuronal populations, and discusses their dysregulation in chronic pain conditions. In addition, it explores the potential role of T-type calcium channels as therapeutic targets for chronic pain.

MOLECULAR BRAIN (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Intrathecal Actions of the Cannabis Constituents Δ(9)-Tetrahydrocannabinol and Cannabidiol in a Mouse Neuropathic Pain Model

Sherelle L. Casey et al.

Summary: Intrathecal administration of THC and CBD, either alone or in combination, effectively reduces neuropathic pain without significant side effects. The anti-allodynic effects of THC are partially mediated by CB1 and CB2 receptors, while the effects of CBD are partially mediated by CB2 receptors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Neurosciences

The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels

Vinicius M. Gadotti et al.

Summary: The terpenes camphene and alpha-bisabolol derived from cannabis plants inhibit Cav3.2 T-type calcium channels, reducing nocifensive responses and thermal hyperalgesia in mice. These compounds also alleviate mechanical hypersensitivity in a mouse model of neuropathic pain, suggesting a wide spectrum of analgesic action by targeting Cav3.2 channels.

MOLECULAR BRAIN (2021)

Add to Collection

Article Pharmacology & Pharmacy