Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science

Research methods to study risk factors and prevention of breast cancer have evolved rapidly. We focus on advances from epidemiologic studies reported over the past two decades addressing scientific discoveries, as well as their clinical and public health translation for breast cancer risk reduction. In addition to reviewing methodology advances such as widespread assessment of mammographic density and Mendelian randomization, we summarize the recent evidence with a focus on the timing of exposure and windows of susceptibility. We summarize the implications of the new evidence for application in risk stratification models and clinical translation to focus prevention-maximizing benefits and minimizing harm. We conclude our review identifying research gaps. These include: pathways for the inverse association of vegetable intake and estrogen receptor (ER)-ve tumors, prepubertal and adolescent diet and risk, early life adiposity reducing lifelong risk, and gaps from changes in habits (e.g., vaping, binge drinking), and environmental exposures.

Automated summary

Research methods for studying risk factors and prevention of breast cancer have rapidly advanced. This review focuses on epidemiological studies over the past two decades, summarizing scientific discoveries and their translation into clinical practice and public health interventions for reducing breast cancer risk. The review highlights the importance of timing of exposure and susceptibility windows and discusses the implications of recent evidence for risk stratification models and clinical translation to maximize prevention benefits and minimize harm.