4.8 Article

Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses

Related references

Note: Only part of the references are listed.
Editorial Material Medicine, General & Internal

Addressing Vaccine Inequity - Covid-19 Vaccines as a Global Public Good

David J. Hunter et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Multidisciplinary Sciences

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera

Alexander Muik et al.

Summary: This study tested the neutralizing ability of sera from participants who received two or three doses of the BNT162b2 COVID-19 vaccine against different SARS-CoV-2 variants. The results showed that after two doses, the neutralizing ability against Omicron was significantly reduced, but a third dose effectively increased the neutralizing ability. This suggests that three doses of the vaccine may provide protection against Omicron-mediated COVID-19.

SCIENCE (2022)

Article Chemistry, Multidisciplinary

Development of Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccines with Broad Neutralization against SARS-CoV-2 Delta and Other Variants

Ran Chen et al.

Summary: This study developed nanoparticle vaccines targeting the SARS-CoV-2 Delta variant and found that they induced the production of neutralizing antibodies, significantly protecting mice from infection by the Delta, early, and Beta strains. Furthermore, by using a trivalent vaccine, cross-protective neutralizing antibodies against other variants, including Omicron, were also observed.

ADVANCED SCIENCE (2022)

Article Microbiology

Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2

John P. Evans et al.

Summary: Recent reports show that SARS-CoV-2 Omicron variant sub-lineages BA.1, BA.1.1, and BA.2 have raised concerns about their ability to escape vaccine-induced and infection-induced immunity. A study finds that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit significant immune escape, but this can be largely overcome by mRNA vaccine booster doses. The findings highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insights into the immunity from natural infection against Omicron sub-lineages.

CELL HOST & MICROBE (2022)

Editorial Material Medicine, General & Internal

Closing the global vaccine equity gap: equitably distributed manufacturing

Victor J. Dzau et al.

LANCET (2022)

News Item Infectious Diseases

Research in brief

Sharmila Devi

LANCET INFECTIOUS DISEASES (2022)

Article Biochemistry & Molecular Biology

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Timothee Bruel et al.

Summary: There are differences in neutralizing activity of therapeutic antibodies against the SARS-CoV-2 Omicron BA.1 and BA.2 sublineages, and immunocompromised individuals treated with antibodies show elevated antibody levels but reduced neutralization against Omicron. Breakthrough infections with the Omicron variant are observed in some immunocompromised individuals despite antibody treatment.

NATURE MEDICINE (2022)

Letter Medicine, General & Internal

Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2

Emi Takashita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Letter Virology

The emergence of Omicron lineages BA.4 and BA.5, and the global spreading trend

Perumal A. Desingu et al.

JOURNAL OF MEDICAL VIROLOGY (2022)

Article Multidisciplinary Sciences

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

Alexander A. Cohen et al.

SCIENCE (2022)

Article Multidisciplinary Sciences

Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses

Tianyang Mao et al.

Summary: This study developed a vaccine strategy called prime and spike, which activates mucosal immune memory within the respiratory tract and induces strong immune responses. It enhances both systemic and local immunity against SARS-CoV-2, and provides full protection against lethal infection in partially immune mice.

SCIENCE (2022)

Article Multidisciplinary Sciences

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

Sho Iketani et al.

Summary: The identification of the Omicron variant of SARS-CoV-2 in Botswana in November 2021 sparked concern due to the spike protein alterations that could potentially evade antibodies. Further studies showed that the Omicron sublineages, BA.1+R346K and BA.2, are antigenically similar to the wild-type virus and pose similar risks to the effectiveness of current vaccines. BA.2 also demonstrated resistance to many neutralizing monoclonal antibodies, highlighting the challenges in developing effective therapeutic options.

NATURE (2022)

Article Multidisciplinary Sciences

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

Novalia Pishesha et al.

Summary: The COVID-19 pandemic has caused over 100 million infections and millions of deaths, prompting the development of a protein-based vaccine targeting antigen-presenting cells. This candidate vaccine shows strong humoral and cellular immunity against SARS-CoV-2 and its variants in both young and aged mice, making it a promising option for combating the virus.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Immunology

Natural and Synthetic Saponins as Vaccine Adjuvants

Pengfei Wang

Summary: Saponin adjuvants, particularly QS-21, have unique immunostimulating activity that induces balanced Th1/Th2 immunity and has been approved for human vaccines. However, the cellular and molecular mechanisms of QS-21 and other saponin adjuvants remain poorly understood, despite efforts to study their mechanisms and develop alternatives to circumvent drawbacks.

VACCINES (2021)

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Immunology

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response

Dusko Lainscek et al.

Summary: This study compared the efficiency of different nanoscaffolding platforms for SARS-CoV-2 vaccine design, finding that fusion of RBD with the small beta-annulus peptide scaffold significantly enhanced antibody titers and virus neutralization, providing a new approach for vaccine design.

VACCINES (2021)

Article Multidisciplinary Sciences

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

Romain Marlin et al.

Summary: The study introduces a new generation of subunit vaccines that target viral antigens to CD40-expressing antigen-presenting cells, demonstrating significant levels of specific T and B cells with long-term memory phenotypes in a humanized mouse model. Moreover, a single dose of the vaccine boosts rapid increase in neutralizing antibodies without adjuvant, improving protection against SARS-CoV-2 variants in non-human primates previously exposed to the virus.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Edurne Rujas et al.

Summary: By using human apoferritin protomer as a modular subunit, researchers have developed exceptionally potent neutralizers targeting SARS-CoV-2. Combining three different antibody specificities and the fragment crystallizable (Fc) domain on a single multivalent molecule enabled the platform to overcome viral sequence variability and deliver ultrapotent neutralizers against SARS-CoV-2. This MULTi-specific, multi-Affinity antiBODY (Multabody or MB) platform leverages binding avidity and multi-specificity to provide broad neutralization against SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice

Wenqiang Sun et al.

Summary: The study developed an mRNA vaccine based on ferritin-formed nanoparticles for SARS-CoV-2, showing adequate protection and broad-spectrum neutralizing antibodies in mice, with the mRNA template easily modifiable to address viral mutations.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Multidisciplinary Sciences

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

Alexander A. Cohen et al.

Summary: The study developed nanoparticles displaying the receptor binding domain (RBD) of SARS-CoV-2 and other animal coronaviruses, which induced cross-reactive antibody responses in mice. Immunization with mosaic RBD nanoparticles resulted in superior neutralization of heterologous viruses, providing a potential strategy for simultaneous protection against multiple coronaviruses.

SCIENCE (2021)

Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

Article Multidisciplinary Sciences

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Lihong Liu et al.

NATURE (2020)

Article Multidisciplinary Sciences

Potently neutralizing and protective human antibodies against SARS-CoV-2

Seth J. Zost et al.

NATURE (2020)

Article Multidisciplinary Sciences

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Johanna Hansen et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

Article Medicine, Research & Experimental

A simple protein-based surrogate neutralization assay for SARS-CoV-2

Kento T. Abe et al.

JCI INSIGHT (2020)

Article Immunology

Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination

Gunnveig Grodeland et al.

JOURNAL OF IMMUNOLOGY (2016)

Review Public, Environmental & Occupational Health

Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs

Nikolai Petrovsky

DRUG SAFETY (2015)

Article Immunology

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Stephen W. Scally et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Editorial Material Biology

Collaboration gets the most out of software

Andrew Morin et al.

ELIFE (2013)

Article Biochemistry & Molecular Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

Sjors H. W. Scheres

JOURNAL OF STRUCTURAL BIOLOGY (2012)

Article Pharmacology & Pharmacy

Overview of global regulatory toxicology requirements for vaccines and adjuvants

Yuansheng Sun et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2012)

Review Immunology

Immunological mechanisms of vaccination

Bali Pulendran et al.

NATURE IMMUNOLOGY (2011)

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Review Genetics & Heredity

The HLA genomic loci map: expression, interaction, diversity and disease

Takashi Shiina et al.

JOURNAL OF HUMAN GENETICS (2009)

Review Biochemistry & Molecular Biology

Inference of macromolecular assemblies from crystalline state

Evgeny Krissinel et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Review Biochemistry & Molecular Biology

Antibody-targeted vaccines

T. Keler et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R

William C. Hwang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody

Ponraj Prabakaran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

WebLogo: A sequence logo generator

GE Crooks et al.

GENOME RESEARCH (2004)