4.8 Article

NF-KB activation enhances STING signaling by altering microtubule-mediated STING trafficking

Related references

Note: Only part of the references are listed.
Review Immunology

Emerging dimensions of cellular cGAS-STING signaling

Baptiste Guey et al.

Summary: This review discusses recent progress in understanding the spatial coordination of DNA-induced cGAS-STING activity and its relevance in balancing innate immune responses, highlighting the importance of context-specific co-factors and suggesting interesting areas for further research into spatial aspects of DNA-induced innate immunity.

CURRENT OPINION IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

ER proteins decipher the tubulin code to regulate organelle distribution

Pengli Zheng et al.

Summary: This study demonstrates that three membrane-bound endoplasmic reticulum proteins interact preferentially with different microtubule populations, influencing organelle positioning and distribution in cells.

NATURE (2022)

Article Cell Biology

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

Xubiao Wei et al.

Summary: LL-37 acts as a transporter for cGAMP, delivering it into target cells to activate the immune response. cGAMP transferred by LL-37 enhances antiviral immunity and inducers such as vitamin D-3 and sodium butyrate enhance LL-37 expression, further strengthening the immune response.

CELL REPORTS (2022)

Review Immunology

The role of cGAS/STING in intestinal immunity

Felix Wottawa et al.

Summary: The gastrointestinal tract is a complex microenvironment constantly interacting with pathogens. Inflammatory bowel disease (IBD) shares characteristics with STING signaling, potentially involving regulation of the microbiota, autophagy, and cell death. Dysregulation of STING signaling may play a significant role in the pathophysiology of IBD.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Cell Biology

The STING phase-separator suppresses innate immune signalling

Xiaoyu Yu et al.

Summary: Yu et al. discovered that STING biomolecular condensates can form in virus-infected cells, leading to the restriction of TBK1 activation and innate immunity responses. The study revealed the presence of a unique STING phase-separator in the ER membrane, which plays a crucial role in regulating innate immune signaling pathways.

NATURE CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C

Ting-Ting Chu et al.

Summary: This study identifies a cGAS- and cGAMP-independent mode of STING activation that affects neuropathology and provides a therapeutic target for the treatment of Niemann-Pick disease type C.

NATURE (2021)

Article Multidisciplinary Sciences

Two cGAS-like receptors induce antiviral immunity in Drosophila

Andreas Holleufer et al.

Summary: In this study, two cGAS-like receptors (cGLR1 and cGLR2) were identified in the fruit fly Drosophila melanogaster, which activate antiviral immunity in response to RNA or DNA viruses. cGLR1 is activated by double-stranded RNA to produce 3'2'-cGAMP, while cGLR2 produces a combination of 2'3'-cGAMP and 3'2'-cGAMP in response to an unknown stimulus. This data establishes cGAS as the founding member of a family of receptors that sense different types of nucleic acids and trigger immunity through the production of cyclic dinucleotides beyond 2'3'-cGAMP.

NATURE (2021)

Review Immunology

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Alexiane Decout et al.

Summary: The cGAS-STING signaling pathway plays a crucial role in inflammation in infection, cellular stress, and tissue damage settings. It has the ability to sense and regulate cellular responses to DNA and has the potential to be targeted in the treatment of various inflammatory diseases.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Immunology

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

Vladislav Pokatayev et al.

NATURE IMMUNOLOGY (2020)

Review Cell Biology

Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Cell Biology

The Tubulin Code in Microtubule Dynamics and Information Encoding

Antonina Roll-Mecak

DEVELOPMENTAL CELL (2020)

Article Immunology

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

Zimu Deng et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Immunology

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Alice Lepelley et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu et al.

Article Biochemistry & Molecular Biology

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

Yunhao Tan et al.

Article Multidisciplinary Sciences

Structural basis of STING binding with and phosphorylation by TBK1

Conggang Zhang et al.

NATURE (2019)

Article Multidisciplinary Sciences

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

Guijun Shang et al.

NATURE (2019)

Review Cell Biology

Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport

Mithila Burute et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

Article Biochemistry & Molecular Biology

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Peng Zhao et al.

Article Cell Biology

Microtubules and Microtubule-Associated Proteins

Holly Goodson et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Review Immunology

Mechanisms of NF-kappa B p65 and strategies for therapeutic manipulation

Sivagami Giridharan et al.

JOURNAL OF INFLAMMATION RESEARCH (2018)

Review Immunology

Evolutionary Origins of cGAS-STING Signaling

Shally R. Margolis et al.

TRENDS IN IMMUNOLOGY (2017)

Article Cell Biology

Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles

Kari Barlan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Review Biochemistry & Molecular Biology

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

Qian Zhang et al.

Review Gastroenterology & Hepatology

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

Dylan K. McDaniel et al.

INFLAMMATORY BOWEL DISEASES (2016)

Article Multidisciplinary Sciences

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

Baoyu Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

Philip J. Kranzusch et al.

MOLECULAR CELL (2015)

Review Immunology

STING: infection, inflammation and cancer

Glen N. Barber

NATURE REVIEWS IMMUNOLOGY (2015)

Article Medicine, General & Internal

Activated STING in a Vascular and Pulmonary Syndrome

Y. Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Xiao-Dong Li et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

Yasuo Tanaka et al.

SCIENCE SIGNALING (2012)

Review Immunology

Intracellular Toll-like Receptors

Amanda L. Blasius et al.

IMMUNITY (2010)

Article Multidisciplinary Sciences

Mutations of optineurin in amyotrophic lateral sclerosis

Hirofumi Maruyama et al.

NATURE (2010)

Review Immunology

Regulation and Function of NF-kappa B Transcription Factors in the Immune System

Sivakumar Vallabhapurapu et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa et al.

NATURE (2009)

Article Multidisciplinary Sciences

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

Wenxiang Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

TLR-4, IL-1R and TNF-R signaling to NF-kappa B: variations on a common theme

L. Verstrepen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biochemistry & Molecular Biology

STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER

Ilya Grigoriev et al.

CURRENT BIOLOGY (2008)

Article Multidisciplinary Sciences

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa et al.

NATURE (2008)

Review Biochemistry & Molecular Biology

Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response

John Hiscott

CYTOKINE & GROWTH FACTOR REVIEWS (2007)

Review Biochemistry & Molecular Biology

TLR signaling

T Kawai et al.

CELL DEATH AND DIFFERENTIATION (2006)

Article Biochemistry & Molecular Biology

The role of the microtubules in tumor necrosis factor-α-induced endothelial cell permeability

I Petrache et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)

Review Biochemistry & Molecular Biology

A universal role for MyD88 in TLR/IL-1R-mediated signaling

S Janssens et al.

TRENDS IN BIOCHEMICAL SCIENCES (2002)

Article Physiology

Role of microtubules in LPS-induced macrophage inflammatory protein-2 production from rat pneumocytes

N Isowa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)