Rabies in Southeast Asia: a systematic review of its incidence, risk factors and mortality

ObjectiveRabies is a neglected zoonotic disease that can infect all mammals, including humans. We aimed to summarise the current knowledge of the incidence, risk factors and mortality of rabies in Southeast Asia.DesignSystematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020.Data sourcesScopus, Web of Science and PubMed were searched from 1 January 2012 to 21 February 2023.Eligibility criteriaOriginal English language articles published between 2012 and 2023 were included.Data extraction and synthesisNine independent reviewers extracted data and assessed the risk of bias. The quality appraisal of included articles was carried out using the Mixed Methods Appraisal Tool.ResultsA total of eight articles were included in this analysis. In Vietnam, the incidence of rabies ranged from 1.7 to 117.2 per 100 000 population. The cumulative incidence in Sarawak was estimated at 1.7 per 100 000 population. In Indonesia, 104 human rabies cases were reported from 2008 to 2010, while in Thailand, a total of 46 rabies cases were reported in Thailand from 2010 to 2015. In the Philippines, the incidence of rabies ranged from 0.1 to 0.3 per 100 000 population. An increased risk of rabies virus infection was associated with a high population density, illiteracy, seasonal patterns and dog butchers. The case fatality rate was 100%.ConclusionThis study included research from Southeast Asia, which may not represent rabies infection in other regions or continents. In addition, the role of publication bias should be acknowledged as grey literature was not included. The occurrence of rabies in Southeast Asia is due to the high number of unvaccinated stray and pet dogs, working hazards (dog butchers in Vietnam), the unavailability of the rabies vaccine in rural regions and misinformation about the significance of seeking treatment after dog bites.PROSPERO registration numberCRD42022311654.

Automated summary

This study summarized the current knowledge of rabies incidence, risk factors, and mortality in Southeast Asia. The incidence of rabies in Vietnam ranged from 1.7 to 117.2 per 100,000 population. In Sarawak, Malaysia, the estimated cumulative incidence was 1.7 per 100,000 population. Indonesia reported 104 human rabies cases from 2008 to 2010, while Thailand reported a total of 46 rabies cases from 2010 to 2015. The incidence of rabies in the Philippines ranged from 0.1 to 0.3 per 100,000 population. High population density, illiteracy, seasonal patterns, and dog butchers were identified as risk factors for rabies virus infection, and the case fatality rate was 100%.