4.4 Review

Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity

Sara Fahs et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Review Oncology

Immuno-oncology Combinations: A Review of Clinical Experience and Future Prospects

Scott J. Antonia et al.

CLINICAL CANCER RESEARCH (2014)

Review Chemistry, Multidisciplinary

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

Valeria Azzarito et al.

NATURE CHEMISTRY (2013)

Review Chemistry, Medicinal

On the selectivity and efficacy of defense peptides with respect to cancer cells

Frederick Harris et al.

MEDICINAL RESEARCH REVIEWS (2013)

Article Multidisciplinary Sciences

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

Swati Kushal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Chemistry, Medicinal

Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-Negative Activity

Hitesh D. Thaker et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Review Biochemistry & Molecular Biology

Update of Peptides with Antibacterial Activity

X. Vila-Farres et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Melissa D. Boersma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Chemistry, Multidisciplinary

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

Avinash Muppidi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Biochemistry & Molecular Biology

Helix-mediated protein-protein interactions as targets for intervention using foldamers

Thomas A. Edwards et al.

AMINO ACIDS (2011)

Review Biochemistry & Molecular Biology

Protein-Protein Interactions in Transcription: A Fertile Ground for Helix Mimetics

Danielle A. Guarracino et al.

BIOPOLYMERS (2011)

Review Cell Biology

Apoptotic cell signaling in cancer progression and therapy

Jessica Plati et al.

INTEGRATIVE BIOLOGY (2011)

Article Chemistry, Organic

Oligophenylenaminones as Scaffolds for α-Helix Mimicry

Marc J. Adler et al.

JOURNAL OF ORGANIC CHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

Chris Phillips et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Biochemistry & Molecular Biology

An orthosteric inhibitor of the Ras-Sos interaction

Anupam Patgiri et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Chemistry, Multidisciplinary

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

Gregory N. Tew et al.

ACCOUNTS OF CHEMICAL RESEARCH (2010)

Article Biochemistry & Molecular Biology

Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

Andrea L. Jochim et al.

ACS CHEMICAL BIOLOGY (2010)

Article Oncology

The global burden of cancer: priorities for prevention

Michael J. Thun et al.

CARCINOGENESIS (2010)

Review Pharmacology & Pharmacy

Current trends in antimicrobial agent research: chemo- and bioinformatics approaches

Riadh Hammami et al.

DRUG DISCOVERY TODAY (2010)

Article Oncology

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

Jacques Ferlay et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

Article Chemistry, Multidisciplinary

Inhibition of Hypoxia Inducible Factor 1-Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

Laura K. Henchey et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Biochemistry & Molecular Biology

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

Michelle L. Stewart et al.

NATURE CHEMICAL BIOLOGY (2010)

Review Cell Biology

Mitochondria and cell death: outer membrane permeabilization and beyond

Stephen W. G. Tait et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26

Ying Zhang et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Chemistry, Organic

N-alkylated oligoamide alpha-helical proteomimetics

Frederick Campbell et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2010)

Article Chemistry, Organic

Synthesis of new phenylpyridyl scaffolds using the Garlanding approach

Anne Sophie Voisin-Chiret et al.

TETRAHEDRON (2010)

Article Biochemistry & Molecular Biology

Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors

Sara J. Buhrlage et al.

ACS CHEMICAL BIOLOGY (2009)

Review Multidisciplinary Sciences

Antifungal and antitumor models of bioactive protective peptides

Elaine G. Rodrigues et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2009)

Article Biochemistry & Molecular Biology

β-Peptides with improved affinity for hDM2 and hDMX

Elizabeth A. Harker et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

Jeffrey P. Plante et al.

CHEMICAL COMMUNICATIONS (2009)

Review Chemistry, Multidisciplinary

Recent advances in the development of aryl-based foldamers

Ishu Saraogi et al.

CHEMICAL SOCIETY REVIEWS (2009)

Review Biochemistry & Molecular Biology

Medicinal Chemistry of Paclitaxel and its Analogues

Y. Fu et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Review Pharmacology & Pharmacy

Cationic amphiphilic peptides with cancer-selective toxicity

Frank Schweizer

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

Review Biochemistry & Molecular Biology

New strategies for novel antibiotics: peptides targeting bacterial cell membranes

Karl Lohner

GENERAL PHYSIOLOGY AND BIOPHYSICS (2009)

Article Biochemistry & Molecular Biology

Assessment of helical interfaces in protein-protein interactions

Andrea L. Jochim et al.

MOLECULAR BIOSYSTEMS (2009)

Article Multidisciplinary Sciences

Cytoplasmic functions of the tumour suppressor p53

Douglas R. Green et al.

NATURE (2009)

Article Multidisciplinary Sciences

Direct inhibition of the NOTCH transcription factor complex

Raymond E. Moellering et al.

NATURE (2009)

Article Chemistry, Organic

Novel Amphiphilic α-Helix Mimetics Based on a Bis-benzamide Scaffold

Srinivasa Marimganti et al.

ORGANIC LETTERS (2009)

Review Obstetrics & Gynecology

MECHANISMS OF CHEMOTHERAPEUTIC DRUG RESISTANCE IN CANCER THERAPY-A QUICK REVIEW

Fu-Shing Liu

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2009)

Article Chemistry, Multidisciplinary

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains

W. Seth Horne et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Review Biochemistry & Molecular Biology

Structural biology of the tumor suppressor p53

Andreas C. Joerger et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Studies on anticancer activities of antimicrobial peptides

David W. Hoskin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

Review Pharmacology & Pharmacy

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

Sharmila Patel et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)

Article Chemistry, Multidisciplinary

Indolocarbazole-based foldamers capable of binding halides in water

Jae-Min Suk et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Chemistry, Organic

Conformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers

Gregory J. Gabriel et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2008)

Article Multidisciplinary Sciences

Estimating the size of the human interactome

Michael P. H. Stumpf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biotechnology & Applied Microbiology

Targeting tumors with peptides from natural sources

Sujit K. Bhutia et al.

TRENDS IN BIOTECHNOLOGY (2008)

Article Chemistry, Multidisciplinary

Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides

Jorge Becerril et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Article Chemistry, Multidisciplinary

Benzoylurea oligomers: Synthetic foldamers that mimic extended alpha helices

Johanna M. Rodriguez et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Article Chemistry, Multidisciplinary

Proteomorphous objects from abiotic backbones

Nicolas Delsuc et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Review Chemistry, Medicinal

Alkylating agents and cancer therapy

Ranju Ralhan et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2007)

Review Biochemistry & Molecular Biology

Anticancer α-helical peptides and structure/function relationships underpinning their interactions with tumour cell membranes

Sarah R. Dennison et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2006)

Review Pharmacology & Pharmacy

Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment

Jamie S. Mader et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2006)

Review Oncology

Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2006)

Review Biochemistry & Molecular Biology

Peptide, peptidomimetic, and small-molecule antagonists of the p53-HDM2 protein-protein interaction

PM Fischer

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2006)

Article Biochemistry & Molecular Biology

Substituted 1,4-benzodiazepine-2,5-diones as α-helix mimetic antagonists of the HDM2-p53 protein-protein interaction

MD Cummings et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2006)

Review Biochemistry & Molecular Biology

Development of small molecules designed to modulate protein-protein interactions

Ye Che et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2006)

Review Biochemistry & Molecular Biology

Detergent-like actions of linear amphipathic cationic antimicrobial peptides

Burkhard Bechinger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)

Article Biochemistry & Molecular Biology

Potent inhibitors of LXXLL-based protein-protein interactions

AK Galande et al.

CHEMBIOCHEM (2005)

Article Cell Biology

Changes in electric charge and phospholipids composition in human colorectal cancer cells

I Dobrzynska et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2005)

Article Oncology

P53 α-helix mimetics antagonize p53/MDM2 interaction and activate p53

LH Chen et al.

MOLECULAR CANCER THERAPEUTICS (2005)

Article Chemistry, Multidisciplinary

Terephthalamide derivatives as mimetics of helical peptides:: Disruption of the Bcl-xL/Bak interaction

H Yin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Biochemistry & Molecular Biology

Host defense peptides as new weapons in cancer treatment

N Papo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

Review Immunology

The role of BH3-only proteins in the immune system

A Strasser

NATURE REVIEWS IMMUNOLOGY (2005)

Review Microbiology

Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?

KA Brogden

NATURE REVIEWS MICROBIOLOGY (2005)

Article Chemistry, Medicinal

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells

BL Grasberger et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Chemistry, Medicinal

1,4-benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR

DJ Parks et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Review Biochemistry & Molecular Biology

Antimicrobial defences in Drosophila:: the story so far

S Naitza et al.

MOLECULAR IMMUNOLOGY (2004)

Article Multidisciplinary Sciences

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

LD Walensky et al.

SCIENCE (2004)

Article Chemistry, Multidisciplinary

Helical β-peptide inhibitors of the p53-hDM2 interaction

JA Kritzer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Review Pharmacology & Pharmacy

Membrane disrupting lytic peptides for cancer treatments

C Leuschner et al.

CURRENT PHARMACEUTICAL DESIGN (2004)

Article Chemistry, Multidisciplinary

Helical peptoid mimics of magainin-2 amide

JA Patch et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Review Oncology

Targeting HIF-1 for cancer therapy

GL Semenza

NATURE REVIEWS CANCER (2003)

Article Multidisciplinary Sciences

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

AM Leduc et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Immunology

Defensins: Antimicrobial peptides of innate immunity

T Ganz

NATURE REVIEWS IMMUNOLOGY (2003)

Article Chemistry, Multidisciplinary

Allosteric inhibition of protein-DNA complexes by polyamide-intercalator conjugates

EJ Fechter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Article Chemistry, Multidisciplinary

Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2

TR Geistlinger et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Review Pharmacology & Pharmacy

Mechanisms of antimicrobial peptide action and resistance

MR Yeaman et al.

PHARMACOLOGICAL REVIEWS (2003)

Article Biochemistry & Molecular Biology

Interactions of the antimicrobial β-peptide β-17 with phospholipid vesicles differ from membrane interactions of magainins

RF Epand et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)

Article Pharmacology & Pharmacy

Antimicrobial peptides from animals: focus on invertebrates

J Vizioli et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2002)

Article Chemistry, Multidisciplinary

Mimicry of host-defense peptides by unnatural oligomers:: Antimicrobial β-peptides

EA Porter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

Article Multidisciplinary Sciences

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

SJ Freedman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Multidisciplinary Sciences

Antimicrobial peptides of multicellular organisms

M Zasloff

NATURE (2002)

Review Chemistry, Multidisciplinary

A field guide to foldamers

DJ Hill et al.

CHEMICAL REVIEWS (2001)

Article Biochemistry & Molecular Biology

β-amino acid scan of a class I major histocompatibility complex-restricted alloreactive T-cell epitope

S Reinelt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Multidisciplinary Sciences

Oncogenic kinase signalling

P Blume-Jensen et al.

NATURE (2001)

Review Developmental Biology

Notch signaling: From the outside in

JS Mumm et al.

DEVELOPMENTAL BIOLOGY (2000)

Article Multidisciplinary Sciences

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters

PA Wender et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.