☆ 4.7 Article

Mitochondrial Calcium Ion Nanogluttons Alleviate Periodontitis via Controlling mPTPs

ADVANCED HEALTHCARE MATERIALS (2023)

Related references

Note: Only part of the references are listed.

Review Cell Biology

Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications

Shanliang Zheng et al.

Summary: Calcium ion (Ca2+) is a widely present and versatile signaling molecule that controls various cellular processes essential for cancer establishment. The dysregulation of Ca2+ homeostasis, particularly in the endoplasmic reticulum (ER), has been considered as a major driving force in the initiation and progression of malignant diseases. This article discusses the ER-centered dysregulation of Ca2+ homeostasis in cancer, summarizes Ca2+-based anticancer therapeutics, and emphasizes the significance of further understanding the regulation of Ca2+ homeostasis in cancer.

TRENDS IN CELL BIOLOGY (2023)

Add to Collection

Review Immunology

Mitochondrial control of inflammation

Saverio Marchi et al.

Summary: This article discusses the molecular mechanisms by which mitochondrial dysfunction leads to inflammatory reactions, the cellular pathways that regulate them, and the pathological consequences of dysregulated inflammatory responses elicited by mitochondrial damage-associated molecular patterns (DAMPs).

NATURE REVIEWS IMMUNOLOGY (2023)

Add to Collection

Review Cell Biology

Molecular mechanisms and consequences of mitochondrial permeability transition

Massimo Bonora et al.

Summary: Mitochondrial permeability transition, mediated by the opening of the mitochondrial permeability transition pore, causes flux of low molecular weight solutes across the inner mitochondrial membrane, triggering various cellular responses. Recent studies have shed light on the molecular nature and mechanisms of the mitochondrial permeability transition pore, paving the way for understanding mitochondrial biology and its pathophysiological consequences.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Nanorepairers Rescue Inflammation-Induced Mitochondrial Dysfunction in Mesenchymal Stem Cells

Qiming Zhai et al.

Summary: Chronic inflammation leads to mitochondrial dysfunction in tissue-specific mesenchymal stem cells (MSCs), but nanotechnology can be utilized to restore their function, providing an effective treatment for periodontitis and osteoarthritis.

ADVANCED SCIENCE (2022)

Add to Collection

Article Engineering, Biomedical

pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats

Lu Wang et al.

Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.

BIOACTIVE MATERIALS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

Xiaofei Li et al.

Summary: Bone marrow-mediated trained innate immunity can enhance immune responsiveness, but maladaptive training can lead to inflammatory comorbidities. Periodontitis can induce maladaptive trained phenotype in the bone marrow, resulting in increased production of myeloid cells with inflammatory preparedness. The trained phenotype of the bone marrow can be transmitted to naive recipients through transplantation and lead to increased inflammatory responsiveness and disease severity. Inhibiting IL-1 signaling can prevent maladaptive training caused by periodontitis.

CELL (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference

Feng Li et al.

Summary: This study develops a dynamic assembly of DNA tetrahedrons inside cells which mediate K+ and efficiently interfere with mitochondria, leading to a regulation of cell energy metabolism. The developed method significantly inhibits cell migration and holds great potential for biomedical applications.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Review Cell Biology

Targeting the mitochondrial permeability transition pore for drug discovery: Challenges and opportunities

Ibrahim Damilare Boyenle et al.

Summary: The mitochondrial permeability transition pore (MPTP) is a pore formed on the inner mitochondrial membrane under calcium overload and oxidative stress, which can cause cell death and has physiological significance. Various models of MPTP have been proposed, with F1Fo ATPase being the most debated candidate protein. Cyclophilin D (CyPD) is widely accepted as the positive regulator of MPTP, but no drug candidate as its inhibitor has emerged.

MITOCHONDRION (2022)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

pHLIP Peptides Target Acidity in Activated Macrophages

Hannah Visca et al.

Summary: This study demonstrates the effective targeting of activated macrophages using pHLIP technology, which has important implications for screening and treatment in specific diseased tissues.

MOLECULAR IMAGING AND BIOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy

Ying Zhou et al.

Summary: In this study, a mitochondrial pathway was established to inhibit tumor growth through the double activation of the mitochondrial permeability transition pore (MPTP) channel. Fe2+ doped covalent organic frameworks (COF) were synthesized and used as templates to grow a CaCO3 shell, resulting in the formation of O-2-FeCOF@CaCO3 nanocomposite. After modification with folic acid (FA), the nanocomposite (OFCCF) could target breast cancer cells and achieve synergistic treatment through photodynamic therapy (PDT) and calcium overload. The multifunctional nanosystem with tumor microenvironment (TME) response abilities provided a novel strategy for clinical cancer therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Review Multidisciplinary Sciences

Inflammatory memory and tissue adaptation in sickness and in health

Shruti Naik et al.

Summary: Our body has the ability to remember past encounters, react more quickly to new threats, and develop resistance to subsequent pathogens. This memory is not limited to the immune system but also extends to epithelia and neurons. However, these memories can also lead to chronic inflammatory disorders and an increased risk of cancer.

NATURE (2022)

Add to Collection

Article Cell & Tissue Engineering

Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

Yaron Meirow et al.

Summary: This study identified two distinct subsets of osteoclast precursors (OCPs) and revealed their different response to inflammatory cues and their role in inflammatory bone loss (IBL). The findings indicate that the Ly6C(hi)CD11b(hi) inflammatory OCPs (iOCPs) play a central role in IBL induction while the Ly6C(hi)CD11b(lo) homeostatic OCPs (hOCPs) remain stable and less affected by inflammation. This study provides insights into the understanding of IBL and suggests iOCPs as potential biomarkers and therapeutic targets for IBL.

BONE RESEARCH (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Smart Design of Nanomaterials for Mitochondria-Targeted Nanotherapeutics

Si Si Liew et al.

Summary: This review summarizes recent developments and strategies in the smart design of nanocarriers for mitochondria-targeted therapeutics, including subcellular targeting, stimuli-responsive nanocarriers, and synergistic therapy, while also discussing existing challenges and unexplored therapeutic opportunities.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Article Mathematics, Applied

Tristability in mitochondrial permeability transition pore opening

Hong Qi et al.

Summary: The study developed a three-variable model to investigate the hypothesis that PTP opening acts as a tristable switch and demonstrated its stability and tristability over a wide range of parameters, as well as the robustness of tristability. The deterministic tristable property was also explained within a stochastic framework, providing valuable insights into the regulatory mechanism of PTP opening.

CHAOS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Advances in Growth Factor Delivery for Bone Tissue Engineering

Erica Resende Oliveira et al.

Summary: Tissue engineering and regenerative medicine have addressed some shortcomings in the treatment of bone diseases, particularly in simulating the extracellular matrix and guiding bone repair. Combining scaffolding and growth factors shows great potential in promoting the effectiveness of bone regeneration methods.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Targeting the Opening of Mitochondrial Permeability Transition Pores Potentiates Nanoparticle Drug Delivery and Mitigates Cancer Metastasis

Xi Lin et al.

Summary: A self-assembled nanoparticle platform is developed to target cancer cells' mitochondria with DNA-intercalating agent doxorubicin, resulting in mitochondrial impairment and inhibition of tumor growth and metastasis. Targeting mitochondria and unlocking MPTP may be effective strategies to mitigate tumorigenesis and metastasis.

ADVANCED SCIENCE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting mitochondrial ion channels for cancer therapy

Ildiko Szabo et al.

Summary: Targeting mitochondrial ion channels with drugs to eliminate cancer cells is a promising approach due to differential expression and/or regulation of these channels in cancer cells compared to healthy cells. Modulation of ion channels can indirectly affect oxidative phosphorylation, which may be crucial for cancer and cancer stem cell survival. Additionally, modulation of mitochondrial ion channels leading to cytochrome c release may be advantageous in overcoming drug resistance.

REDOX BIOLOGY (2021)

Add to Collection

Review Immunology

The 'cytokine storm': molecular mechanisms and therapeutic prospects

Rajendra Karki et al.

Summary: CSS is a collection of clinical manifestations caused by an overactivated immune system, associated with infectious diseases, immunodeficiencies, and therapeutic interventions. Despite the tissue damage and multiorgan failure caused by CS, there is still a lack of systematic understanding of its underlying molecular mechanisms.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

Jingbo Qin et al.

Summary: This review summarizes the state of the art of design and construction of nanosystems used for mitochondria-targeted delivery in cancer treatment. It discusses the use of nanotechnology through various pathways such as energy metabolism interference, ROS regulation, mitochondrial protein targeting, mtDNA interference, mitophagy inducing, and combination therapy. Finally, it provides an overview of the major challenges and future prospects in this field.

NANOSCALE (2021)

Add to Collection

Article Materials Science, Biomaterials

An oligopeptide/aptamer-conjugated dendrimer-based nanocarrier for dual-targeting delivery to bone

Mingxing Ren et al.

Summary: A new dual-targeting nanocarrier, CH6-PAMAM-C11, was synthesized by covalently modifying G4.0 PAMAM dendrimer with C11 peptide and CH6 aptamer, showing successful accumulation in bone cells, mineralized areas, and tissues. Both in vitro and in vivo experiments confirmed the efficient bone targeting ability of CH6-PAMAM-C11, suggesting potential for drug delivery to bone tissues for osteoporosis treatment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Add to Collection

Review Immunology

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

George Hajishengallis et al.

Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.

NATURE REVIEWS IMMUNOLOGY (2021)

Add to Collection

Article Chemistry, Medicinal

The mitochondrial permeability transition pore in cell death: A promising drug binding bioarchitecture

Salvatore Nesci

MEDICINAL RESEARCH REVIEWS (2020)

Add to Collection

Review Cell Biology

Mitochondrial ion channels as targets for cardioprotection

Derek J. Hausenloy et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

Qiyi Zhao et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages

Dominic T. Love et al.

REDOX BIOLOGY (2020)

Add to Collection

Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Review Cell Biology

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives

Shobha Regmi et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit

Francisco J. Roca et al.

CELL (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

Nirmal Robinson et al.

REDOX BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis

Linlin Gu et al.

REDOX BIOLOGY (2019)

Add to Collection

Review Cell Biology

ER-Mitochondria Communication in Cells of the Innate Immune System

Dmitry Namgaladze et al.

CELLS (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Elimination of Intracellular Calcium Overload by BAPTA-AM-Loaded Liposomes: A Promising Therapeutic Agent for Acute Liver Failure

Zailin Fu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Review Cell Biology

Macrophage immunomodulation in chronic osteolytic diseases-the case of periodontitis

Corneliu Sima et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Add to Collection

Review Immunology

Clinical application of injectable growth factor for bone regeneration: a systematic review

Yutaka Kuroda et al.

INFLAMMATION AND REGENERATION (2019)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Resolving Macrophages Counter Osteolysis by Anabolic Actions on Bone Cells

A. Viniegra et al.

JOURNAL OF DENTAL RESEARCH (2018)

Add to Collection

Review Cell Biology

Mitochondria: A master regulator in macrophage and T cell immunity

Pu-Ste Liu et al.

MITOCHONDRION (2018)

Add to Collection

Review Urology & Nephrology

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Yufang Shi et al.

NATURE REVIEWS NEPHROLOGY (2018)

Add to Collection

Review Immunology

Mitochondria: An Organelle of Bacterial Origin Controlling Inflammation

Alain Meyer et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Review Cell Biology

The machineries, regulation and cellular functions of mitochondrial calcium

Carlotta Giorgi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

Maria Jose Perez et al.

REDOX BIOLOGY (2018)

Add to Collection

Review Biotechnology & Applied Microbiology

Mitochondria as a therapeutic target for common pathologies

Michael P. Murphy et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Add to Collection

Review Materials Science, Multidisciplinary

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

Fereydoon Abedi-Gaballu et al.

APPLIED MATERIALS TODAY (2018)

Add to Collection

Article Immunology

Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps

Martina Behnen et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Microbiology

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

Sebastian Aguirre et al.

NATURE MICROBIOLOGY (2017)

Add to Collection

Review Cell Biology

The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore

Hagai Rottenberg et al.

AGING CELL (2017)

Add to Collection

Review Immunology

Mitochondria are the powerhouses of immunity

Evanna L. Mills et al.

NATURE IMMUNOLOGY (2017)

Add to Collection

Letter Medicine, General & Internal

Cyclosporine before PCI in Acute Myocardial Infarction

Carlos G. Santos-Gallego et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Add to Collection

Review Immunology

Mitochondria in the Regulation of Innate and Adaptive Immunity

Samuel E. Weinberg et al.

IMMUNITY (2015)

Add to Collection

Review Cardiac & Cardiovascular Systems

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

Andrew P. Halestrap et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Add to Collection

Article Materials Science, Multidisciplinary

PAMAM dendrimers as promising nanocarriers for RNAi therapeutics

Prashant Kesharwani et al.

MATERIALS TODAY (2015)

Add to Collection

Review Endocrinology & Metabolism

Stromal cells and stem cells in clinical bone regeneration

Warren L. Grayson et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology

Subhashini Bolisetty et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Add to Collection

Article Immunology

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

Kenichi Shimada et al.

IMMUNITY (2012)

Add to Collection

Review Biotechnology & Applied Microbiology

Inflammatory bone loss: pathogenesis and therapeutic intervention

Kurt Redlich et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Add to Collection

Review Cell Biology

Mitochondria as sensors and regulators of calcium signalling

Rosario Rizzuto et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Add to Collection

Review Immunology

Mitochondria: Sovereign of inflammation?

Juerg Tschopp

EUROPEAN JOURNAL OF IMMUNOLOGY (2011)

Add to Collection

Review Immunology

Mitochondria in innate immune responses

A. Phillip West et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Add to Collection

Review Oncology

Mitochondria as targets for cancer chemotherapy

Vladimir Gogvadze et al.

SEMINARS IN CANCER BIOLOGY (2009)

Add to Collection

Article Pharmacology & Pharmacy

The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells

Qiang Tang et al.

BIOCHEMICAL PHARMACOLOGY (2007)

Add to Collection

Review Biotechnology & Applied Microbiology

The cyclophilins

P Wang et al.

GENOME BIOLOGY (2005)

Add to Collection

Review Biochemistry & Molecular Biology

Cyclophilin D as a drug target

PC Waldmeier et al.

CURRENT MEDICINAL CHEMISTRY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.