☆ 4.7 Article

Multi-Catcher Polymers Regulate the Nucleolin Cluster on the Cell Surface for Cancer Therapy

ADVANCED HEALTHCARE MATERIALS (2023)

Related references

Note: Only part of the references are listed.

Article Engineering, Biomedical

Regulated extravascular microenvironment via reversible thermosensitive hydrogel for inhibiting calcium influx and vasospasm

Binfan Zhao et al.

Summary: This study constructs a reversible, intelligent, responsive thermosensitive hydrogel system that can inhibit vasospasm by regulating the extravascular microenvironment. The hydrogel releases drugs to prevent tissue necrosis when the tissue temperature drops. Animal experiments demonstrate that this hydrogel can promote tissue survival and alleviate tissue injury.

BIOACTIVE MATERIALS (2023)

Add to Collection

Review Chemistry, Multidisciplinary

Directed Evolution of Aptamer Discovery Technologies

Diana Wu et al.

Summary: This article introduces four techniques developed in the laboratory to accelerate the discovery of high-quality aptamer reagents. These techniques include particle display, multiparametric particle display, click chemistry-based particle display, and non-natural aptamer array platform. The application of these techniques makes aptamer technology more accessible, efficient, and robust.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

Add to Collection

Review Chemistry, Multidisciplinary

How Do Biomolecules Cross the Cell Membrane?

Dehua Pei

Summary: This paper introduces a previously unrecognized membrane translocation mechanism called the vesicle budding-and-collapse (VBC) mechanism. Through VBC, biomolecules can autonomously translocate across cell membranes. The study found that CPPs and bacterial protein toxins can escape endosomes through the VBC mechanism, and proposed that VBC may be the mechanism that drives the bacterial TAT and eukaryotic UPS systems.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Membrane Cholesterol Depletion Enhances Enzymatic Activity of Cell-Membrane-Coated Metal-Organic-Framework Nanoparticles

Shuyan Wang et al.

Summary: This study discovers that the enzymatic activity of cell-membrane-coated MOF nanoparticles (MOF NPs) can be significantly enhanced by reducing membrane cholesterol content. The researchers find that reducing cholesterol levels effectively enhances membrane permeability, which is likely responsible for the increased enzymatic activity. This finding provides a facile approach to tailor the enzymatic activity of cell-membrane-coated MOF NPs by simply tuning the membrane cholesterol level.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Nucleolin: a cell portal for viruses, bacteria, and toxins

Fiorella Tonello et al.

Summary: Nucleolin is a protein mainly localized in the nucleolus, but it also acts as a receptor on the cell surface for various pathogens. Its multivalence and role as a bridge between the nucleus and cell surface allow it to interact with different biomolecules and participate in various subcellular locations.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Manipulating Nanoparticle Aggregates Regulates Receptor-Ligand Binding in Macrophages

Yuri Kim et al.

Summary: In this study, the modulation of receptor-ligand interactions in cells using magnetic nanoparticle aggregates is investigated. Manipulating the accessible ligand dispersity can either promote macrophage adhesion and healing or suppress it depending on the ligand accessibility. This study presents accessible ligand dispersity as a novel parameter that regulates receptor-ligand binding and polarization of macrophages.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Editorial Material Oncology

Special issue: Targeting cellular signaling pathways for cancer therapy

Peter Zhiwei Wang et al.

SEMINARS IN CANCER BIOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Modular Assembly of a Concatenated DNA Circuit for In Vivo Amplified Aptasensing

Qiong Wu et al.

Summary: This research presents a multilayer nonenzymatic catalytic DNA circuits-based aptasensing system, which enables in situ imaging of bioactive molecules in living mice. The aptasensing system shows high sensitivity, accuracy, and adaptability, making it suitable for analyzing various bioactive molecules.

SMALL (2022)

Add to Collection

Editorial Material Cell Biology

Nucleolin: a binding partner of G-quadruplex structures

Tiago Santos et al.

Summary: Through observing various pieces of evidence, we emphasize the significant relevance of the partnership between nucleolin and G-quadruplex structures to neurodegenerative diseases, cancer, and viral infections.

TRENDS IN CELL BIOLOGY (2022)

Add to Collection

Article Neurosciences

Receptor-Interacting Protein 3/Calmodulin-Dependent Kinase II/Proline-Rich Tyrosine Kinase 2 Pathway is Involved in Programmed Cell Death in a Mouse Model of Brain Ischaemic Stroke

Binbin Wang et al.

Summary: In this study, the authors identified the involvement of the RIP3/CaMKII/Pyk2 pathway in programmed cell death after brain ischaemic stroke, and found that inhibiting necroptosis and apoptosis can reduce cerebral infarction volume and neurological deficits. This pathway may serve as a promising therapeutic target for ischaemia-induced neuronal injury.

NEUROSCIENCE (2022)

Add to Collection

Article Multidisciplinary Sciences

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

Emily Sempou et al.

Summary: Changes in membrane potential can affect calcium levels and mTOR in pluripotent stem cells, altering their transition from pluripotency to differentiation. Understanding this transition is important for embryonic development, tissue homeostasis, and therapeutic applications.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Soft nano and microstructures for the photomodulation of cellular signaling and behavior

Nicolas Muzzio et al.

Summary: Photoresponsive soft materials have diverse applications in modulating cellular behavior, tissue engineering and regenerative medicine, drug delivery, and phototherapies.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection

Article Engineering, Environmental

Tumor site-specific PEG detachment and active tumor homing of therapeutic PEGylated chitosan/folate-decorated polydopamine nanoparticles to augment antitumor efficacy of photothermal/chemo combination therapy

Ming-Hung Hsieh et al.

Summary: This study developed versatile polymeric nanoparticles that selectively deliver chemotherapy drugs to tumor sites in response to tumor extracellular acidity, promoting enhanced antitumor efficacy. The nanoparticles showed excellent stability and drug release characteristics, and achieved significant tumor accumulation and inhibition of tumor growth in vivo.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo

M. Tommy Gambles et al.

Summary: Drug-Free Macromolecular Therapeutics (DFMT) is a new approach for inducing cell apoptosis without using low molecular weight drugs. By crosslinking receptors, DFMT effectively initiates programmed cell death in various B cell malignancies. Simultaneous engagement and crosslinking of multiple targets further enhances the efficacy of DFMT. The combination of DFMT on CD20 and CD38 receptors shows potent apoptosis induction and synergistic effects.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Aptamer-Functionalized Nanodevices for Dynamic Manipulation of Membrane Receptor Signaling in Living Cells

Zhimin Wang et al.

Summary: This study developed a novel nanodevice that can dynamically regulate cellular behavior and specific molecular events in biological systems. By combining conformational switch and aptamer molecular recognition, this device showed excellent performance in modulating receptor-mediated immune responses.

NANO LETTERS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time

Anand Patwardhan et al.

Summary: G protein-coupled receptors (GPCRs) are a large family of signaling receptors that regulate cellular and physiologic responses, implicated in various diseases. Although phosphorylation is a major regulator of GPCR signaling, other post-translational modifications (PTMs) such as ubiquitination, glycosylation, and palmitoylation play important roles in GPCR biology, yet understanding of these PTMs is limited. Comprehensive understanding of diverse PTMs is crucial for elucidating dysregulated mechanisms in disease and improving drug development for GPCRs.

PHARMACOLOGICAL REVIEWS (2021)

Add to Collection

Article Multidisciplinary Sciences

Fanconi anemia A protein participates in nucleolar homeostasis maintenance and ribosome biogenesis

Anna Gueiderikh et al.

Summary: FANCA deficiency is associated with nucleolar homeostasis loss, mislocalization of key nucleolar proteins, as well as alterations in ribosome biogenesis and protein synthesis, challenging current hypothesis on FA physiopathology.

SCIENCE ADVANCES (2021)

Add to Collection

Review Neurosciences

Mitochondria and Calcium in Alzheimer's Disease: From Cell Signaling to Neuronal Cell Death

Maria Calvo-Rodriguez et al.

Summary: Mitochondrial dysfunction plays a crucial role in the pathogenesis of neurological diseases, including AD. Besides the link between mitochondrial dynamics and amyloid beta toxicity, dysregulation of mitochondrial calcium homeostasis is also related to other risk factors in AD. Researchers have reviewed the latest literature on mitochondrial dysregulation in AD, highlighting the potential of mitochondrial calcium transporters as therapeutic candidates for developing neuroprotective drugs against AD.

TRENDS IN NEUROSCIENCES (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Advances in receptor modulation strategies for flexible, efficient, and enhanced antitumor efficacy

Dan-Dan Wang et al.

Summary: Modulating receptors on tumor cells is crucial for enhancing targeted therapy, improving treatment concentration, and increasing effectiveness.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides

Yang Wang et al.

Summary: The nanoscale spatial organization of TNF receptors on cell surfaces plays a crucial role in regulating cellular fate. The use of DNA origami nanostructures to pattern TNF-related apoptosis-inducing ligand-mimicking peptides has shown potential in inducing death receptor clustering and apoptosis in human breast cancer cells, offering a new strategy to improve TNF superfamily activation methods.

ACS NANO (2021)

Add to Collection

Review Biotechnology & Applied Microbiology

Aptamers: Cutting edge of cancer therapies

Sarah Shigdar et al.

Summary: The development of aptamer-based therapeutics has rapidly progressed, with eleven aptamers entering clinical trials for various therapeutic indications. Despite some success in pre-clinical and clinical studies, no aptamer has been FDA-approved for cancer treatment. Recent research focuses on enhancing anti-cancer immunity, targeting hard-to-treat cancers, and developing carrier aptamers for delivering RNA therapeutics.

MOLECULAR THERAPY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Therapeutic applications of AS1411 aptamer, an update review

Rezvan Yazdian-Robati et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability

Lingling Wu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors

Da Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection

Article Chemistry, Analytical

Extracellular Ion-Responsive Logic Sensors Utilizing DNA Dimeric Nanoassemblies on Cell Surface and Application to Boosting AS1411 Internalization

Pai Peng et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells

Fengfei Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function

Liping Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

被撤回的出版物: A DNA Nanodevice Simultaneously Activating the EGFR and Integrin for Enhancing Cytoskeletal Activity and Cancer Cell Treatment (Retracted article. See vol. 22, pg. 3175, 2022)

Mirza Muhammad Faran Ashraf Baig et al.

NANO LETTERS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface

Lian Li et al.

ACS NANO (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions

Kanyu Xun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Tumor-Specific Aptamer-Conjugated Polymeric Photosensitizer for Effective Endo-Laparoscopic Photodynamic Therapy

Jiyoung Kim et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics

Lian Li et al.

ACS NANO (2018)

Add to Collection

Article Neurosciences

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

Caterina Masaracchia et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy

Hao-Ran Jia et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection

Article Multidisciplinary Sciences

Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

Maria Jose Lista et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Calcium regulates cell death in cancer: Roles of the mitochondria and mitochondria-associated membranes (MAMs)

Alberto Danese et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)

Add to Collection

Article Chemistry, Multidisciplinary

A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer-Directed Cell Recruitment

Xiaoxia Hu et al.

ADVANCED MATERIALS (2017)

Add to Collection

Article Nanoscience & Nanotechnology

Thermo-Controlled in Situ Phase Transition of Polymer-Peptides on Cell Surfaces for High-Performance Proliferative Inhibition

Sheng-Lin Qiao et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Add to Collection

Article Engineering, Biomedical

DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding

Chun Mei Li et al.

BIOMATERIALS (2016)

Add to Collection

Article Materials Science, Biomaterials

Imaging plasma membranes without cellular internalization: multisite membrane anchoring reagents based on glycol chitosan derivatives

Hong-Yin Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Old, new and emerging functions of caspases

S. Shalini et al.

CELL DEATH AND DIFFERENTIATION (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Cell Surface Self-Assembly of Hybrid Nanoconjugates via Oligonucleotide Hybridization Induces Apoptosis

Te-Wei Chu et al.

ACS NANO (2014)

Add to Collection

Article Hematology

Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex

Jillian F. Wise et al.

BLOOD (2013)

Add to Collection

Article Chemistry, Physical

A magnetic switch for the control of cell death signalling in in vitro and in vivo systems

Mi Hyeon Cho et al.

NATURE MATERIALS (2012)

Add to Collection

Article Oncology

Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras

Keren Farin et al.

CANCER RESEARCH (2011)

Add to Collection

Review Multidisciplinary Sciences

Dynamic molecular processes mediate cellular mechanotransduction

Brenton D. Hoffman et al.

NATURE (2011)

Add to Collection

Article Peripheral Vascular Disease

Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculature

Valentina Fogal et al.

ANGIOGENESIS (2009)

Add to Collection

Article Oncology

The cell surface expressed nucleolin is a glycoprotein that triggers calcium entry into mammalian cells

Marie-Estelle Losfeld et al.

EXPERIMENTAL CELL RESEARCH (2009)

Add to Collection

Review Nanoscience & Nanotechnology

Nanocarriers as an emerging platform for cancer therapy

Dan Peer et al.

NATURE NANOTECHNOLOGY (2007)

Add to Collection

Article Hematology

Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin

Hubing Shi et al.

BLOOD (2007)

Add to Collection

Article Hematology

The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin

Y Huang et al.

BLOOD (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin

EA Said et al.

FEBS JOURNAL (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.