An Antibacterial and Anti-Oxidative Hydrogel Dressing for Promoting Diabetic Wound Healing and Real-Time Monitoring Wound pH Conditions with a NIR Fluorescent Imaging System

Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

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Article Chemistry, Physical

A ionic liquid enhanced conductive hydrogel for strain sensing applications

Yonghui Zhou et al.

Summary: A novel ionic liquid segmental polyelectrolyte hydrogel with improved tensile behavior and conductivity was developed in this study, showing great potential for monitoring various movements.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Multidisciplinary

A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Ye Wu et al.

Summary: The injectable glycopeptide hydrogel fabricated in this study possesses multifunctionality, including inherent antibacterial and antioxidant capabilities, as well as the ability to promote angiogenesis and accelerate wound healing. The spatiotemporal delivery of therapeutic agents within the hydrogel allows for effective anti-infection, anti-oxidation, and anti-inflammation effects, making it a promising strategy for treating chronic diabetic wounds.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Engineering, Biomedical

Extracellular Matrix-Based Conductive Interpenetrating Network Hydrogels with Enhanced Neurovascular Regeneration Properties for Diabetic Wounds Repair

Lei Fan et al.

Summary: A conductive dressing synthesized from an interpenetrating polymer network hydrogel has been developed to promote diabetic wound healing by enhancing local neurovascular regeneration. This dressing combines water-swollen hydrogels with conductive polymers to provide tissue-matching electrical conductivity and mechanical properties for neurovascular regeneration. In vitro and in vivo studies show that the conductive hydrogel can promote neurovascular regeneration by increasing intracellular Ca2+ concentration, leading to phosphorylation of proteins in key signaling pathways, ultimately stimulating full-thickness diabetic wound repair.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Materials Science, Biomaterials

Ionic liquid functionalized injectable and conductive hyaluronic acid hydrogels for the efficient repair of diabetic wounds under electrical stimulation

Pan Liu et al.

Summary: The treatment and care of diabetic wounds is a global challenge, but electrical stimulation has proven to be effective in promoting healing. Novel hydrogels based on hyaluronic acid with excellent electrical conductivity and mechanical properties were prepared, which exhibited significant antibacterial effects. Coupled with external electrical stimulation, these hydrogels accelerated diabetic wound healing compared to commercial films.

BIOMATERIALS SCIENCE (2022)

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Article Nanoscience & Nanotechnology

Copper-Hydrazide Coordinated Multifunctional Hyaluronan Hydrogels for Infected Wound Healing

Junmin Qian et al.

Summary: In this study, a series of hyaluronan (HA)-metal hydrogels were successfully constructed using the hydrazide-metal coordination crosslinking method. The hydrazide-Cu(II) coordination imparted the HA-Cu hydrogel with physicochemical multifunctions, including self-healing, shear-thinning injectability, and reversible pH/redox/ion pair triple responsiveness. The HA-Cu hydrogel exhibited robust antibacterial activity and accelerated wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

A Polyphenol-Network-Mediated Coating Modulates Inflammation and Vascular Healing on Vascular Stents

Bo Zhang et al.

Summary: Localized drug delivery from drug-eluting stents can provide therapeutic efficacy with minimal systemic toxicity. The researchers in this study developed a micro- to nanoscale network assembly composed of copper ion and epigallocatechin gallate (EGCG), which can release rapamycin and promote endothelial cell growth. The coated stents exhibited long-term antithrombotic efficacy and attenuated the negative impact of rapamycin on endothelial cells.

ACS NANO (2022)

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Article Engineering, Environmental

Multifunctional hydrogel as wound dressing for intelligent wound monitoring

Lirong Wang et al.

Summary: The multifunctional hydrogel wound dressing promotes wound healing by providing antibacterial, hemostatic, and adhesive properties, while also enabling real-time monitoring of wound status. The personalized wound management model accurately analyzes and evaluates wound healing and infection status using the colorimetric signal of the hydrogel dressing, achieving high accuracy.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Nanoscience & Nanotechnology

Superior, Environmentally Tolerant, Flexible, and Adhesive Poly(ionic liquid) Gel as a Multifaceted Underwater Sensor

Liduo Rong et al.

Summary: A multifunctional adhesive, conductive poly(ionic liquid) gel has been developed with stable conductivity, excellent environmental resistance, and adhesion, suitable for applications in underwater or underwater conditions as smart sensors and ECG signal transmission.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Sustained Release of Nitric Oxide and Cascade Generation of Reactive Nitrogen/Oxygen Species via an Injectable Hydrogel for Tumor Synergistic Therapy

Yaoben Wang et al.

Summary: A novel injectable hydrogel system capable of releasing nitric oxide (NO) and converting it into reactive nitrogen species (RNS) has been developed, which effectively boosts hydrogen peroxide (H2O2) concentration in cancer cells and suppresses tumor growth.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Engineering, Biomedical

A nanofibrous membrane loaded with doxycycline and printed with conductive hydrogel strips promotes diabetic wound healing in vivo

Wangbei Cao et al.

Summary: A wound dressing with immunomodulation and electroconductivity properties was prepared and tested for its effectiveness in promoting diabetic wound healing. The dressing successfully accelerated skin regeneration, collagen deposition, revascularization, and re-epithelialization in diabetic wounds. It achieved this by regulating the wound microenvironment, scavenging reactive oxygen species (ROS), and polarizing macrophages to the M2 phenotype.

ACTA BIOMATERIALIA (2022)

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Article Materials Science, Biomaterials

A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds

Yile Jia et al.

Summary: A pH-responsive hyaluronic acid-collagen hydrogel was designed to reconstruct the ECM in diabetic wounds, promoting wound healing by enhancing fibroblast adhesion and infiltration and inhibiting macrophage growth.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Pharmacology & Pharmacy

Supramolecular engineering of hydrogels for drug delivery

Stephane Bernhard et al.

Summary: Supramolecular binding motifs are increasingly utilized in the design of biomaterials, particularly in drug delivery systems. Rational engineering of specific associations enables injectable or sprayable hydrogels, achieving minimally invasive administration in drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Engineering, Biomedical

A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion

Yang Yuan et al.

Summary: A novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond was designed for dynamic burn wounds, showing enhanced physicochemical properties and efficacy, suitable for wounds with irregular shapes.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

Yifei Lu et al.

Summary: This study presents a novel approach of using a delivery system comprising living Lactococcus to bioengineer the wound microenvironment and enhance angiogenesis in a highly dynamic-temporal manner, aiming to drive rapid healing in chronic wounds.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real-Time Monitoring and Promotion of Wound Healing

Kaikai Zheng et al.

Summary: The study presents multifunctional hydrogels for real-time monitoring of wound healing, which can detect pH level, reduce bacterial infection, and promote wound healing simultaneously. The hybridization of CQDs and pH indicator with the hydrogels allows for high responsiveness and accurate indication of pH variability, enabling real-time evaluation of wound conditions. These hydrogels have potential as a smart and flexible wound dressing platform for theranostic skin regeneration.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary